Structural characterization of a polysaccharide from Dioscorea opposita and assessment of its hepatoprotective activity

Bu, Wei; Dai, Wei-Wei; Liu, Han-meng; Bu, Huimin; Ju, Xiuyun; Li, Rong-peng; Yuan, Bo

doi:10.1016/j.procbio.2022.05.024

Cited by 7 publications

(2 citation statements)

References 48 publications

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“…The signal peak at about 1070 cm −1 was ascribed to the symmetric stretching vibration of the C-O-C [ 32 ]. Compared to the unmodified polysaccharides that were reported in our previous study [ 3 ], the new absorption peak that was found at about 1740 cm −1 was attributed to the vibration of C=O of the O-acetyl group, and the enhanced absorption peak at around 1245 cm −1 was caused by the asymmetric stretching vibration of C-O-C in carbonyl groups, which proved that the two acetylated polysaccharides were successfully modified [ 6 , 33 ].…”

Section: Resultsmentioning

confidence: 53%

Acetylation Modification, Characterization, and Anticomplementary Activity of Polysaccharides from Rhododendron dauricum Leaves

Sun

Jin

et al. 2022

Polymers

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This study focuses on the acetylation modification of polysaccharides from Rhododendron dauricum leaves (RDPs) with a high degree of substitution (DS) and then discusses their characterization and biological activity. The optimum acetylation conditions of RDPs were optimized by response surface methodology, which were reaction time 3 h, reaction temperature 50 °C, and the liquid-solid ratio 16 mL/g. Under the optima schemes, two eco-friendly acetylated polysaccharides from R. dauricum leaves (AcRDP-1 with DS of 0.439 ± 0.025 and AcRDP-2 with DS of 0.445 ± 0.022) were prepared. The results of structural characterization showed that the AcRDP-1 (9.3525 × 103 kDa) and AcRDP-2 (4.7016 × 103 kDa) were composed of mannose, glucose, galactose, and arabinose with molar ratios of 1.00:5.01:1.17:0.15 and 1.00:4.47:2.39:0.88, respectively. Compared with unmodified polysaccharides, the arabinose content and molecular weight of the two acetylated polysaccharides decreased, and their triple helix conformation disappeared, and further improved their anticomplementary activity. The two acetylated polysaccharides showed stronger a complement inhibition effect than the positive drug by blocking C2, C3, C4, C5, C9, and factor B targets in the classical and alternative pathways. This research indicated that acetylation modification could effectively enhance the anticomplementary activity of RDPs, which is beneficial for the development and utilization of R. dauricum leaves.

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Section: Resultsmentioning

confidence: 53%

Acetylation Modification, Characterization, and Anticomplementary Activity of Polysaccharides from Rhododendron dauricum Leaves

Sun

Jin

et al. 2022

Polymers

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“…DOP-2 can improve BaP-induced liver injury by enhancing the activity of immune and antioxidant enzymes, exhibiting hepatoprotective activity. Moreover, DOP-2 can modulate the concentration of organic acids to increase the fecal absorption of BaP [ 41 ].…”

Section: Bioactive Compoundsmentioning

confidence: 99%

Dioscorea spp.: Bioactive Compounds and Potential for the Treatment of Inflammatory and Metabolic Diseases

et al. 2023

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Dioscorea spp. belongs to the Dioscoreaceae family, known as “yams”, and contains approximately 600 species with a wide distribution. It is a major food source for millions of people in tropical and subtropical regions. Dioscorea has great medicinal and therapeutic capabilities and is a potential source of bioactive substances for the prevention and treatment of many diseases. In recent years, increasing attention has been paid to the phytochemicals of Dioscorea, such as steroidal saponins, polyphenols, allantoin, and, in particular, polysaccharides and diosgenin. These bioactive compounds possess anti-inflammatory activity and are protective against a variety of inflammatory diseases, such as enteritis, arthritis, dermatitis, acute pancreatitis, and neuroinflammation. In addition, they play an important role in the prevention and treatment of metabolic diseases, including obesity, dyslipidemia, diabetes, and non-alcoholic fatty liver disease. Their mechanisms of action are related to the modulation of a number of key signaling pathways and molecular targets. This review mainly summarizes recent studies on the bioactive compounds of Dioscorea and its treatment of inflammatory and metabolic diseases, and highlights the underlying molecular mechanisms. In conclusion, Dioscorea is a promising source of bioactive components and has the potential to develop novel natural bioactive compounds for the prevention and treatment of inflammatory and metabolic diseases.

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Hepatoprotective Effect Against Cadmium-Induced Liver Toxicity in Rats of Foeniculum vulgare Seed Polysaccharides

et al. 2023

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Structural characterization of a polysaccharide from Dioscorea opposita and assessment of its hepatoprotective activity

Cited by 7 publications

References 48 publications

Acetylation Modification, Characterization, and Anticomplementary Activity of Polysaccharides from Rhododendron dauricum Leaves

Acetylation Modification, Characterization, and Anticomplementary Activity of Polysaccharides from Rhododendron dauricum Leaves

Dioscorea spp.: Bioactive Compounds and Potential for the Treatment of Inflammatory and Metabolic Diseases

Hepatoprotective Effect Against Cadmium-Induced Liver Toxicity in Rats of Foeniculum vulgare Seed Polysaccharides

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