Structural characterization of a polysaccharide from Radix Hedysari and its protective effects against H2O2-induced injury in human gastric epithelium cells

Xue, Zhixin; Zhao, Lianggong; Wang, Donghan; Chen, Xinyue; Liú, Dan; Liu, Xiaohua; Feng, Shilan

doi:10.1016/j.ijbiomac.2021.08.151

Cited by 6 publications

(8 citation statements)

References 38 publications

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“…Most of M w values for gastroprotective polysaccharides are smaller than 500 kDa (X. Y. Wang, Yin, Nie, et al., 2018; X. Y. Wang et al., 2022; Q. Yang et al., 2012; Sousa et al., 2016; da Silva & Parente, 2010). Monosaccharide types of Ara, galactose (Gal), and glucose (Glc) are widely found in them (Baggio et al., 2012; Cipriani et al., 2008, 2006; Correa‐Ferreira et al., 2018; de Oliveira et al., 2018; Guo et al., 2020; Jouini et al., 2017; Lengsfeld, Titgemeyer, et al., 2004; Malafaia et al., 2015; Maria‐Ferreira et al., 2013; Nascimento et al., 2017, 2013; Scoparo et al., 2016; Salem et al., 2017; Xue et al., 2021; Q. Yang et al., 2012). 1‐, 1,2‐, 1,3‐, 1,4‐, 1,5‐, 1,6‐, 1,2,4‐, 1,3,4‐, 1,3,6‐ and/or 1,4,6‐glycosidic bond types are determined in gastroprotective polysaccharides (Lengsfeld, Titgemeyer, et al., 2004; Liao & Huang, 2019; Maria‐Ferreira et al., 2013; Scoparo et al., 2016; Xue et al., 2021).…”

Section: Structural Features Of Gastroprotective Polysaccharidesmentioning

confidence: 99%

“…Monosaccharide types of Ara, galactose (Gal), and glucose (Glc) are widely found in them (Baggio et al., 2012; Cipriani et al., 2008, 2006; Correa‐Ferreira et al., 2018; de Oliveira et al., 2018; Guo et al., 2020; Jouini et al., 2017; Lengsfeld, Titgemeyer, et al., 2004; Malafaia et al., 2015; Maria‐Ferreira et al., 2013; Nascimento et al., 2017, 2013; Scoparo et al., 2016; Salem et al., 2017; Xue et al., 2021; Q. Yang et al., 2012). 1‐, 1,2‐, 1,3‐, 1,4‐, 1,5‐, 1,6‐, 1,2,4‐, 1,3,4‐, 1,3,6‐ and/or 1,4,6‐glycosidic bond types are determined in gastroprotective polysaccharides (Lengsfeld, Titgemeyer, et al., 2004; Liao & Huang, 2019; Maria‐Ferreira et al., 2013; Scoparo et al., 2016; Xue et al., 2021). According to the structural features, they could be mostly categorized as pectins, arabinogalactans, heteroxylans, sulfated polysaccharides, glucans, glucomannans, fructans, fucogalactans, and others.…”

Section: Structural Features Of Gastroprotective Polysaccharidesmentioning

confidence: 99%

“…Yang et al, 2012;Sousa et al, 2016;da Silva & Parente, 2010). Monosaccharide types of Ara, galactose (Gal), and glucose (Glc) are widely found in them (Baggio et al, 2012;Cipriani et al, 2008Cipriani et al, , 2006Correa-Ferreira et al, 2018;de Oliveira et al, 2018;Guo et al, 2020;Jouini et al, 2017;Lengsfeld, Titgemeyer, et al, 2004;Malafaia et al, 2015;Maria-Ferreira et al, 2013;Nascimento et al, 2017Nascimento et al, , 2013Scoparo et al, 2016;Salem et al, 2017;Xue et al, 2021;Q. Yang et al, 2012).…”

Section: Structural Features Of Gastroprotective Polysaccharidesmentioning

confidence: 99%

“…Yang et al, 2012). 1-, 1,2-, 1,3-, 1,4-, 1,5-, 1,6-, 1,2, 4-, 1,3,4-, 1,3,6-and/or 1,4,6-glycosidic bond types are determined in gastroprotective polysaccharides (Lengsfeld, Titgemeyer, et al, 2004;Maria-Ferreira et al, 2013;Scoparo et al, 2016;Xue et al, 2021). According to the structural features, they could be mostly categorized as pectins, arabinogalactans, heteroxylans, sulfated polysaccharides, glucans, glucomannans, fructans, fucogalactans, and others.…”

Section: Structural Features Of Gastroprotective Polysaccharidesmentioning

confidence: 99%

“…In vitro: IC 50 on H + , K + -ATPase activity was 420 μg/ml; MIC on H. pylori was 156 μg/ml Acetic acid-induced rats GU (-); gastric mucin, GSH and PGE 2 (+); TBARS, protein carbonyl, galectin-3, MMP-2, and MMP-9 (-) (Srikanta et al, 2010) (Continues) TA B L E 1 (Continued) or ethanol-induced rats; anti-H. pylori; inhibition of H + , K + -ATPaseIn vivo: GU (-); gastric mucin, GSH and CAT (+); TBARS and H + , K + -ATPase activity (-). In vitro: IC 50 on H + , K + -ATPase activity was 77 μg/ml; MIC on H. pylori was 55 μg/ml(Srikanta et al, 2007)(Xue et al, 2021) Acetic acid-induced rats GU (-); T-SOD, CAT, PGE 2 and NO (+); MDA, IL-6 and TNF-α (-)(Xue et al, 2019)…”

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confidence: 99%

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Gastroprotective polysaccharide from natural sources: Review on structure, mechanism, and structure–activity relationship

Wang

Yin

et al. 2022

Food Frontiers

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Polysaccharides from natural sources have the potentials in being used as substitutes of chemosynthetic drugs for gastroprotection because of its safety and efficacy.For giving a better understanding of gastroprotective polysaccharides, the research progress on preparation, structure, bioactivity, and their action mechanism is comprehensively summarized in this review. Moreover, the structure-activity relationship of gastroprotective polysaccharides is discussed. Accumulating evidence has indicated that natural polysaccharides, which were widely prepared by water extraction and column chromatography purifications, exhibited gastroprotective effects in vitro and in vivo. The action mechanism might be related to gastric secretions, promotion of gastric defensive factor releases, antioxidation, anti-inflammatory, antiapoptosis, and facilitation of proliferation. Phenolic compounds, molecular weight and conformation, monosaccharide composition, backbone structure and side chain, and functional group have great influences on the gastroprotective activities of polysaccharides. This review gives comprehensive guidance to the exploitation and application of natural polysaccharides in food and other industries for gastroprotection.

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Section: Structural Features Of Gastroprotective Polysaccharidesmentioning

confidence: 99%

Section: Structural Features Of Gastroprotective Polysaccharidesmentioning

confidence: 99%

Section: Structural Features Of Gastroprotective Polysaccharidesmentioning

confidence: 99%

Section: Structural Features Of Gastroprotective Polysaccharidesmentioning

confidence: 99%

mentioning

confidence: 99%

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Gastroprotective polysaccharide from natural sources: Review on structure, mechanism, and structure–activity relationship

Wang

Yin

et al. 2022

Food Frontiers

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Preparation of composite calcium phosphate cement scaffold loaded with Hedysarum polysaccharides and its efficacy in repairing bone defects

Zhao,

Wang,

Feng

et al. 2024

J Mater Sci: Mater Med

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It’s imperative to create a more ideal biological scaffold for bone defect repair. Calcium phosphate bone cements (CPC) could be used as a scaffold. Some ingredients and osteogenic factors could be added to improve its poor mechanical properties and biological activity. As a macromolecule extracted from traditional Chinese medicine, Hedysarum polysaccharides (HPS) would significantly promote the osteogenic activity of bone biomaterials. Zirconium oxide and starch were added to the solid phase and citric acid was added to the liquid phase to optimize CPC. HPS was loaded onto the scaffold as an osteogenic factor, and the prepared CPS + HPS was characterized. Further, the cytocompatibility of CPS + HPS was assessed according to activity, differentiation, and calcification in neonatal rat calvarial osteoblasts, and the biosafety of CPS + HPS was evaluated according to acute toxicity, pyrogen, sensitization, and hemolysis. The success of CPS + HPS in repairing bone defects was evaluated by using a rabbit femur implantation experiment. After optimization, CPS-20-CA-5 containing 10% starch and 5% citric acid displayed the highest mechanical strength of 28.96 ± 0.03 MPa. HPS-50 was demonstrated to exert the best osteogenic effect. The combination of CPS + HPS achieved HPS-loaded CPC. Material characterization, cytocompatibility, biosafety, and femoral implantation experiments indicated that CPS + HPS possessed better pressure resistance and improved osteogenic ability in bone defect repair.CPS + HPS demonstrated effective pressure resistance and superior osteogenic ability, which may be of great significance for bone defects and bone tissue engineering to promote bone regeneration and repair. Graphical Abstract The composite CPS loaded with HPS-50 is an excellent scaffold with fine load-bearing ability and sustained release of osteogenic factors to repair bone defects.

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Effects of a polysaccharide extract from Amomum villosum Lour. on gastric mucosal injury and its potential underlying mechanism

Liu

Zhuang

Liang

et al. 2022

Carbohydrate Polymers

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Structural characterization of a polysaccharide from Radix Hedysari and its protective effects against H2O2-induced injury in human gastric epithelium cells

Cited by 6 publications

References 38 publications

Gastroprotective polysaccharide from natural sources: Review on structure, mechanism, and structure–activity relationship

Gastroprotective polysaccharide from natural sources: Review on structure, mechanism, and structure–activity relationship

Preparation of composite calcium phosphate cement scaffold loaded with Hedysarum polysaccharides and its efficacy in repairing bone defects

Effects of a polysaccharide extract from Amomum villosum Lour. on gastric mucosal injury and its potential underlying mechanism

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