Structural characterization of a heteropolysaccharide from the fruit of Crataegus pinnatifida and its bioactivity on the gut microbiota of immunocompromised mice

Jing, Yongshuai; Zhang, Yameng; Yan, Meng; Zhang, Ruijuan; Hu, Beibei; Sun, Shiguo; Zhang, Danshen; Zheng, Yuguang; Wu, Liqing

doi:10.1016/j.foodchem.2023.135658

Cited by 9 publications

(4 citation statements)

References 36 publications

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“…Crataegus pinnatifida Polysaccharide (CPP) was prepared by water extraction and alcohol precipitation ( 24 ). In brief, Crataegus pinnatifida fruit was processed with 90% ethanol (1:5, w/v) twice for 3 h to remove alcohol-soluble compounds, fat-soluble chemicals, and colors.…”

Section: Methodsmentioning

confidence: 99%

A study on the treatment effects of Crataegus pinnatifida polysaccharide on non-alcoholic fatty liver in mice by modulating gut microbiota

Hao,

Yang,

Yin

et al. 2024

Front. Vet. Sci.

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The objective of this study was to investigate the protective effect of Crataegus pinnatifida polysaccharide (CPP) on non-alcoholic fatty liver disease (NAFLD) induced by a high-fat diet (HFD) in mice. The findings demonstrated that CPP improved free fatty acid (FFA)-induced lipid accumulation in HepG2 cells and effectively reduced liver steatosis and epididymal fat weight in NAFLD mice, as well as decreased serum levels of TG, TC, AST, ALT, and LDL-C. Furthermore, CPP exhibited inhibitory effects on the expression of fatty acid synthesis genes FASN and ACC while activating the expression of fatty acid oxidation genes CPT1A and PPARα. Additionally, CPP reversed disturbances in intestinal microbiota composition caused by HFD consumption. CPP decreased the firmicutes/Bacteroidetes ratio, increased Akkermansia abundance, and elevated levels of total short-chain fatty acid (SCFA) content specifically butyric acid and acetic acid. Our results concluded that CPP may intervene in the development of NAFLD by regulating of intes-tinal microbiota imbalance and SCFAs production. Our study highlights that CPP has a potential to modulate lipid-related pathways via alterations to gut microbiome composition thereby ex-erting inhibitory effects on obesity and NAFLD development.

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Section: Methodsmentioning

confidence: 99%

A study on the treatment effects of Crataegus pinnatifida polysaccharide on non-alcoholic fatty liver in mice by modulating gut microbiota

Hao,

Yang,

Yin

et al. 2024

Front. Vet. Sci.

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“…It can be seen that DZMPs can improve constipation by regulating intestinal flora. Jing et al [78] fed HFD rats with low-molecularweight polysaccharides from Rosa laevigata Michx, which could significantly reduce the ratio of Firmicutes/Bacteroidetes, increase the relative abundance of Alistipes, Prevotella, and Akkermansia, and regulate intestinal tract microbiome. Wang et al [73] studied flavonoids in parsley and found that flavonoids also played an important role in the regulation of intestinal microecology.…”

Section: Effect Of Improving Intestinal Floramentioning

confidence: 99%

Research Progress on Bioactive Components and Their Functions of Fruits and Vegetables

Wang

et al. 2023

FNC

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Globally, humans are at the risk of increasing incidence of metabolic diseases, the occurrence of which is closely linked to people's daily diet. Fruits and vegetables are one of the important daily food types of people. Varieties of plant secondary metabolites are contained in fruits and vegetables, including phenolic acids, flavonoids, anthraquinones, terpenoids, alkaloids, steroidal saponins and polysaccharides. These metabolites usually have multiply bioactive functions, such as antioxidant, antitumor, hypoglycemic, hypolipidemic, neuroprotection, anti-inflammatory, antibacterial and disease prevention, which is of great importance in preventing the occurrence of human metabolic diseases. However, the composition and content, bioactive functions and mechanisms of action of these metabolites in different types of fruits and vegetables vary greatly. The research progress of the main bioactive components of fruits and vegetables and their multi-functions are reviewed in this paper to promote people's understanding and utilization of functional components of fruits and vegetables.

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“…Crataegus pinnatifida (CP), known as Shan Zha or hawthorn, is a popular functional food in China. It has a tart-sweet taste and is abundant in phenols, flavonoids, terpenoids, fiber, and organic acids [ 12 , 13 , 14 ]. It has been documented that these chemical constituents exhibit a wide range of pharmacological effects, including anticancer properties, antioxidant activity, improvement of glycolipid metabolism, and facilitation of digestive processes [ 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…It has a tart-sweet taste and is abundant in phenols, flavonoids, terpenoids, fiber, and organic acids [ 12 , 13 , 14 ]. It has been documented that these chemical constituents exhibit a wide range of pharmacological effects, including anticancer properties, antioxidant activity, improvement of glycolipid metabolism, and facilitation of digestive processes [ 12 , 13 , 14 , 15 , 16 ]. Wolfiporia extensa (WE), or Fu Ling, is an edible fungus with a long consumption history.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

Yuan,

Hu,

Yang

et al. 2024

Foods

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Obesity is a multifactorial chronic metabolic disease with multiple complications. Crataegus pinnatifida (CP) and Wolfiporia extensa (WE) are traditional functional foods with improving metabolic health properties. This study demonstrated the effect of CP and WE combination on ameliorating obesity induced by a high-fat diet (HFD). Moreover, the CP-WE food pair ameliorated HFD-induced metabolic disorders, including glucose intolerance, insulin resistance, hyperlipidemia, and hepatic steatosis. 16S rRNA gene amplicon sequencing and analysis revealed that CP combined with WE reshaped the composition of gut microbiota in HFD-fed mice. Furthermore, correlation analysis revealed a substantial association between the obesity-related parameters and the shifts in predominant bacterial genera influenced by the food pair intervention. In conclusion, this study demonstrated that the CP-WE food pair ameliorated HFD-induced obesity and reshaped gut microbiota composition, providing a promising approach to combat obesity through specific food combinations.

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Structural characterization of a heteropolysaccharide from the fruit of Crataegus pinnatifida and its bioactivity on the gut microbiota of immunocompromised mice

Cited by 9 publications

References 36 publications

A study on the treatment effects of Crataegus pinnatifida polysaccharide on non-alcoholic fatty liver in mice by modulating gut microbiota

A study on the treatment effects of Crataegus pinnatifida polysaccharide on non-alcoholic fatty liver in mice by modulating gut microbiota

Research Progress on Bioactive Components and Their Functions of Fruits and Vegetables

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

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