Structural characterization, biological evaluation and DNA interaction of some potential drugs based on bifunctional aldehyde functionality

Abstract

Recent work aimed at evaluating the possibility of enhancing biological activities by synthetically modifying bifunctional aldehyde structures. In this article, two series of bifunctional aldehydes were synthesized, structurally characterized (M-1A, M-1C and M-2A) using single crystal X-ray diffraction analysis. Several pharmacological properties like cytotoxic, antifungal, antibacterial, antioxidant and antitumor activities were also evaluated. In addition, bifunctional aldehyde-DNA interaction assay was examined by UV-Vis spectroscopy which revealed the DNA damaging behaviour of these aldehydes. The results of UV-Vis spectroscopy were supported by DNA damaging assay. The overall results reveal that bifunctional aldehyde moiety could be used as potential drug candidates.

Enhanced microwave absorption properties of magnetite nanoparticles decorated multi walled carbon nanotubes loaded polyaniline/polyvinyl alcohol nanocomposites

“…Following the method described in the preceding investigations DiAl was synthesized 46–48 . By carefully adding 1,4‐dibromobutane (0.01 mole), p‐hydroxy benzaldehyde (0.02 mole) and potassium carbonate (50 mole) to a DMF solution in a 100 mL round bottom flask fitted with a reflux condenser.…”

“…Following the method described in the preceding investigations DiAl was synthesized. [46][47][48] By carefully adding 1,4-dibromobutane (0.01 mole), p-hydroxy benzaldehyde (0.02 mole) and potassium carbonate (50 mole) to a DMF solution in a 100 mL round bottom flask fitted with a reflux condenser. The mixture was refluxed for 24 h at 80 C under N 2 environment, and cooled to ambient temperature, filtered and then purified by re-suspending it in 100 mL of DI water.…”