Structural Characterization and Modifications of Surface-oxidized Cellulose Nanofiber

Isogai, Akira

doi:10.1627/jpi.58.365

Cited by 19 publications

(14 citation statements)

References 72 publications

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“…Key variables are the operating pressure and the number of passes. Kekalainen et al (2014a,b;2015) achieved related effects using an inline homogenizer, where the suspension passed between a rotor and stator with a gap of less than 1 mm between alternating sets of teeth projecting into the high-shear zone. Naderi et al (2015c) considered a strategy to potentially reduce the energy and improve the outcomes of treatment in a homogenizer.…”

Section: Fibrillation Meansmentioning

confidence: 99%

“…Treatment of cellulose with the relatively stable free-radical species 2,2,6,6tetramethylpiperidine-1-oxyl radical (TEMPO) in the presence of an oxidizing agent has become a popular route to the production of NFC under reduced energy requirements (Lasseuguette 2008;Lasseuguette et al 2008;Johnson et al 2009;Hirota et al 2010;Besbes et al 2011a,b;Ishii et al 2011;Loranger et al 2012a,b;Mishra et al 2012;Araki 2013;Benhamou et al 2014;Fukuzumi et al 2014;Kekalainen et al 2014aKekalainen et al , 2015Lindström and Aulin 2014;Mohtaschemi et al 2014a,b;Nechyporchuk et al 2014Nechyporchuk et al , 2015Bettaieb et al 2015;Jowkarderis et al 2015;Martoia et al 2015Martoia et al , 2016Rees et al 2015;Pääkkönen et al 2016;Xu et al 2016). In addition to facilitating the fibrillation of the material, TEMPO-mediated oxidation also imparts a negative charge to the surfaces (at pH values near to or above the pKa value of the carboxylic acids) (Hirota et al 2010;Fukuzumi et al 2014;Isogai 2015). Because the TEMPO system tends to exclusively oxidize the C6-hydroxyl groups of cellulose, it causes only a moderate reduction of molecular mass (Isogai et al 2011).…”

Section: Chemical Assistance To Fibrillationmentioning

confidence: 99%

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Rheology of nanocellulose-rich aqueous suspensions: A Review

Hubbe

Tayeb

Joyce

et al. 2017

BioRes

223

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The flow characteristics of dilute aqueous suspensions of cellulose nanocrystals (CNC), nanofibrillated cellulose (NFC), and related products in dilute aqueous suspensions could be of great importance for many emerging applications. This review article considers publications dealing with the rheology of nanocellulose aqueous suspensions in the absence of matrix materials. In other words, the focus is on systems in which the cellulosic particles themselves – dependent on their morphology and the interactive forces between them – largely govern the observed rheological effects. Substantial progress in understanding rheological phenomena is evident in the large volume of recent publications dealing with such issues including the effects of flow history, stratification of solid and fluid layers during testing, entanglement of nanocellulose particles, and the variation of inter-particle forces by changing the pH or salt concentrations, among other factors. Better quantification of particle shape and particle-to-particle interactions may provide advances in future understanding. Despite the very complex morphology of highly fibrillated cellulosic nanomaterials, progress is being made in understanding their rheology, which supports their usage in applications such as coating, thickening, and 3D printing.

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Section: Fibrillation Meansmentioning

confidence: 99%

Section: Chemical Assistance To Fibrillationmentioning

confidence: 99%

Rheology of nanocellulose-rich aqueous suspensions: A Review

Hubbe

Tayeb

Joyce

et al. 2017

BioRes

223

View full text Add to dashboard Cite

show abstract

“…As a biocompatible and biologically active scaffold, we focused on nanocellulose (NC)‐based hydrogel. NC is a naturally occurring nanofibril composed of fully extended 30–40 cellulose chains (Isogai, ). NC has emerged as a functional nanocolloid for composite material, gas barrier film, microelectronics, and cell culture scaffold (Dash, Foston, & Ragauskas, ; Dong, Snyder, Williams, & Andzelm, ; Li et al, ; Moon, Martini, Nairn, Simonsen, & Youngblood, ; Yang, Bakaic, Hoare, & Cranston, ).…”

Section: Introductionmentioning

confidence: 99%

Sustained‐immunostimulatory nanocellulose scaffold to enhance vaccine efficacy

Nishiguchi

Taguchi

2020

J Biomedical Materials Res

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An implantable scaffold‐based vaccination system is a promising platform to generate robust immune responses by modulating the immune system. However, establishment of an effective vaccine using a biodegradable, cell‐infiltrative scaffold remain challenging. Here we demonstrate a biodegradable, nanocellulose‐based immune scaffold capable of sustainably activating immune cells to elicit cellular immunity. Cell‐infiltrative nanocellulose hydrogels were used as a delivery carrier and cellular scaffold microenvironment. Nanofibrous hydrogels allowed for high cell infiltration and delivery of antigen‐loaded nanocellulose while cells degraded the hydrogel matrix. Importantly, antigen‐loaded nanocellulose hydrogels exhibited sustained activation of macrophages in vitro compared to free antigen and collagen scaffold. Histological observation revealed infiltration of macrophages and dendritic cells into the nanocellulose scaffold subcutaneously implanted in mice. In vivo fluorescence imaging indicated that the implanted scaffold released antigens at a zero‐order release profile without burst diffusion. Antigen‐loaded nanocellulose hydrogels increased interferon‐γ‐producing cells compared to free antigen injection, suggesting the enhancement of cellular immunity. Thus, nanocellulose immune scaffold may serve as a sustained‐immunostimulatory vaccine platform by providing favorable microenvironments for immune cells thus enhancing vaccine efficacy.

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“…NC is a plant-derived crystalline cellulose fibril with a width of few nanometers that can be fabricated via nanofibrillation of the cell wall. In the cell wall, 30–40 fully extended cellulose chains are hierarchically aligned via strong intermolecular hydrogen bonding to form cellulose microfibrils . Because of their unique structural properties, such as high specific surface area, high aspect ratio, and high mechanical strength, entanglement of NC can yield colloidal gels, which can be used as a cell culture scaffold. − Although various NCs, including mechanically disintegrated NC, bacterial cellulose, and 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)-oxidized NC, have been investigated, little is known about the utility of NC in biomedical applications, since NC is not biodegradable, because of its high crystallinity .…”

Section: Introductionmentioning

confidence: 99%

A Thixotropic, Cell-Infiltrative Nanocellulose Hydrogel That Promotes in Vivo Tissue Remodeling

Nishiguchi

Taguchi

2020

ACS Biomater. Sci. Eng.

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Injectable gels have been used in minimally invasive surgery for tissue regeneration and treatment of inflammatory diseases. However, polymeric hydrogels often fail in cell infiltration, because of the presence of dense, cross-linked molecular networks and a lack of bioactivity, which causes delayed tissue remodeling. Here, we report a thixotropic, cell-infiltrative hydrogel of biofunctionalized nanocellulose that topologically enhances cell infiltration and biochemically upregulates cellular activity for the promotion of tissue remodeling. Biodegradable, sulfonated nanocellulose forms a nanofibrous hydrogel, mimicking cellular microenvironments through cross-linking between nanocellulose and gelatin. Resulting nanocellulose hydrogels showed thixotropy, allowing for single syringe injection. Nanofiber-based hydrogels possess high molecular permeability, which is due to nanoporous structures. Sulfonate groups on nanocellulose increase protein adsorption and induce cellular extension in vitro. Highly sulfonated nanocellulose hydrogels enhanced cell infiltration and vascularization upon implantation into rats. Macrophage polarization to M2 was observed in nanocellulose hydrogels, which may be involved in tissue remodeling. Injectable, biofunctionalized nanocellulose gels have enormous potential as artificial biomatrices to heal inflammatory diseases through manipulation of the immune system and promotion of tissue remodeling.

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Structural Characterization and Modifications of Surface-oxidized Cellulose Nanofiber

Cited by 19 publications

References 72 publications

Rheology of nanocellulose-rich aqueous suspensions: A Review

Rheology of nanocellulose-rich aqueous suspensions: A Review

Sustained‐immunostimulatory nanocellulose scaffold to enhance vaccine efficacy

A Thixotropic, Cell-Infiltrative Nanocellulose Hydrogel That Promotes in Vivo Tissue Remodeling

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