Structural characterization and in vitro antitumor activity of A polysaccharide from Artemisia annua L. (Huang Huahao)

Yan, Liang; Xiong, Chuan; Xu, Pan; Zhu, Jing; Yang, Zhou; Ren, Hongqiang; Luo, Qiang

doi:10.1016/j.carbpol.2019.02.081

Cited by 54 publications

(17 citation statements)

References 53 publications

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“…reported that MP extraction thought different methods were mainly composed of glucose, galactose and galacturonic acid with ratios of 1.00:2.49:0.19, 1.00:2.95:0.84 and 1.00:1.34:0.25, which was discrepant with our dates possibly for the different extraction methods and raw material origins. The monosaccharide compositions can even be influenced via the growth stage of plants ( Yan et al, 2019 ). Thus, raw materials may also be an important factor in the monosaccharide compositions of MP.…”

Section: Resultsmentioning

confidence: 99%

Changes in polysaccharides structure and bioactivity during Mesona chinensis Benth storage

Chen

Xiao

Shen

et al. 2022

Current Research in Food Science

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Section: Resultsmentioning

confidence: 99%

Changes in polysaccharides structure and bioactivity during Mesona chinensis Benth storage

Chen

Xiao

Shen

et al. 2022

Current Research in Food Science

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“…In recent years, it has been found that Artemisia polysaccharides have an anti-inflammatory effect ( 13 ). It can induce apoptosis of cancer cells, improve immunity, and show anti-liver cancer properties ( 14 ). Therefore, we can focus on its extraction research.…”

Section: Introductionmentioning

confidence: 99%

Optimization of the Artemisia Polysaccharide Fermentation Process by Aspergillus niger

et al. 2022

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In order to investigate the fermentation process of Artemisia polysaccharides, this paper showcases an investigation into the effects of fermentation time, fermentation temperature, strain inoculum, Artemisia annua addition, and shaker speed on the polysaccharides production of Artemisia annua. The yield of Artemisia polysaccharides content was determined based on the optimization of single-factor test, and then a response surface test was conducted with temperature, inoculum, and time as response variables and the yield of Artemisia polysaccharides as response values. The fermentation process was then optimized and the antioxidant activity of Artemisia polysaccharides was monitored using DPPH, ABTS+, OH, and total reducing power. The optimum fermentation process was determined by the test to be 5% inoculum of Aspergillus niger, temperature 36°C, time 2 d, shaker speed 180 r/min, and 4% addition of Artemisia annua, and the extraction of Artemisia polysaccharides was up to 17.04% by this condition of fermentation. The polysaccharides from Artemisia annua fermented by Aspergillus Niger had scavenging effects on DPPH, ABTS, and OH free radicals.

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“…Therefore, it is necessary to develop or discover new low toxicity drugs for cancer treatment. The mouse hepatocellular carcinoma (HCC) cell line H22 is used extensively to establish an animal tumor model 4 , and cyclophosphamide (CTX) is mostly used as the positive control drug to investigate the antitumor effects of bioactive compounds 5 .…”

Section: Introductionmentioning

confidence: 99%

Influence of Pholiota adiposa on gut microbiota and promote tumor cell apoptosis properties in H22 tumor-bearing mice

Wang

Zhang

Liu

2022

Sci Rep

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Hepatocellular carcinoma (HCC) is a common type of cancer—prevalent worldwide—and one of the causes of cancer-related deaths. In this study, ethanol extracts from Pholiotaadiposa (EPA) were used to identify possible targets for HCC treatment and their effects on intestinal microflora were analyzed. Methods: Male mice were randomly assigned to groups—the model group, cyclophosphamide (25 mg/kg/d), and EPA groups, in which the mice were categorized based on the different concentrations of each compound (100, 200, and 300 mg/kg/day). Relevant biochemical indicators were detected using ELISA, H&E staining, and TUNEL assay. Four tumor apoptosis-related proteins and genes, Cleaved Caspases, BAX, Bcl-2, and VEGF, were detected by immunohistochemical staining, western blotting, and RT-PCR. The total genomic DNA was obtained from the contents of the small intestine and colon and was sequenced. The V3 + V4 regions of bacterial 16 s rDNA (from 341 to 806) were amplified. Results: The tests revealed that EPA exhibited antitumor activity in vivo by promoting apoptosis and inhibiting angiogenesis. Moreover, EPA treatment could increase beneficial and decrease harmful microflorae. These results demonstrate that EPA may be a potential therapy for HCC.

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Structural characterization and in vitro antitumor activity of A polysaccharide from Artemisia annua L. (Huang Huahao)

Cited by 54 publications

References 53 publications

Changes in polysaccharides structure and bioactivity during Mesona chinensis Benth storage

Changes in polysaccharides structure and bioactivity during Mesona chinensis Benth storage

Optimization of the Artemisia Polysaccharide Fermentation Process by Aspergillus niger

Influence of Pholiota adiposa on gut microbiota and promote tumor cell apoptosis properties in H22 tumor-bearing mice

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