Structural characterization and immunomodulatory activity of a polysaccharide from Dioscotea opposita

Li, Pengyue; Jing, Yongshuai; Qiu, Xiaoyue; Xiao, Huina; Zheng, Yuguang; Wu, Lanfang

doi:10.1016/j.ijbiomac.2024.130734

Cited by 2 publications

(1 citation statement)

References 82 publications

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“…Also, in their mouse model, DOP reduced the damage caused by CTX in the immunosuppressed animals. Tissue disorganization was also attenuated in DOP-treated animals, especially regarding Thymus, spleen, and colon histopathology [33]. These polysaccharides promote the production of short-chain fatty acids (SCFAs) that are crucial in supporting gut health and immune function.…”

Section: Immunomodulationmentioning

confidence: 99%

Polysaccharides from Medicinal Plants: Bridging Ancestral Knowledge with Contemporary Science

Pedrosa,

Fabi

2024

Plants

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Plants are a core part of cultural identity, as part of a diet, decorations, ceremonies, or as medicinal agents. Empirical knowledge regarding plants and their healing potential has existed worldwide for centuries. With the advance of science and technology, not only is the refinement of such sources or isolation of specific compounds possible, but these compounds can also be characterized based on their natural occurrence. Besides their importance for plant metabolism and structure, polysaccharides have been demonstrated to have substantial positive human health impacts on inflammation, metabolism, oxidative stress, and others. As an inherent part of plant cell walls, many polysaccharides from medicinal herbs, such as fructans, glucans, and pectins, have been extracted and analyzed for their structure and function. However, a review summarizing a significant portion of these studies was still unavailable. This review helps to fill the knowledge gap between polysaccharide bioactivity, their structure, and their plant matrix sources, focusing on historical medicinal usage.

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Section: Immunomodulationmentioning

confidence: 99%

Polysaccharides from Medicinal Plants: Bridging Ancestral Knowledge with Contemporary Science

Pedrosa,

Fabi

2024

Plants

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Characterization of salt brine sulfated polysaccharides: immunomodulatory activity based on gut microbiota

Jia,

Ma,

Xiao

et al. 2024

Blue Biotechnology

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A sulfated polysaccharide consisting of two components with molecular weights of 439 kDa and 16 kDa was extracted from the salt brine. The structural properties, immunomodulatory activity, in vitro fermentation behaviors, and effects of SP on regulating the gut microbiota were investigated. The chemical composition and monosaccharide composition analysis showed that the neutral sugar, protein, uronic acid, and sulfated group contents of SP were 60.42 ± 0.04%, 2.90 ± 0.01%, 13.34 ± 0.01% and 10.51 ± 0.01%, respectively, containing arabinose, galactose, glucose, rhamnose, xylose, mannose, and glucuronic acid in a molar ratio of 33.24:19.18:16.64:13.25:8.31:4.11:5.27. Results from the macrophage cell model showed that SP intervention improved the proliferation activity, phagocytosis of neutral red, and production of IL-6 and TNF-α in RAW 264.7. Furthermore, in vitro fermentation of SP by gut microbiota showed that SCFA production in all treatment groups was significantly higher than that of the blank control group after 48 h of fermentation, especially butyric acid which was 1.70 folds that of the control group. Moreover, long-term fermentation (48 h) of SP improved the diversity of microbiota, decreased the F/B ratio (30.75 at 0 h vs. 1.22 at 48 h), and promoted the growth of probiotics (Parabacteroides, Bacteroidetes, Ruminococcaceae, and Phascolarctobacterium). The positive regulatory effect of SP on the gut microbiota and its metabolites is considered a potential target for its immunomodulatory activity. Graphical abstract

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Structural characterization and immunomodulatory activity of a polysaccharide from Dioscotea opposita

Cited by 2 publications

References 82 publications

Polysaccharides from Medicinal Plants: Bridging Ancestral Knowledge with Contemporary Science

Polysaccharides from Medicinal Plants: Bridging Ancestral Knowledge with Contemporary Science

Characterization of salt brine sulfated polysaccharides: immunomodulatory activity based on gut microbiota

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