Structural characterization and hydrolytic degradation of solid copolymers of d,l-lactide-co-ε-caprolactone by Raman spectroscopy

Kister, G; Cassanas, G.; Bergounhon, M.; Hoarau, Didier; Vert, Michel

doi:10.1016/s0032-3861(99)00223-2

Cited by 145 publications

(115 citation statements)

References 9 publications

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“…51 In the Raman spectra of polymer grafted cell walls, we observed a clear signal related to the presence of -CH 2 -groups from PCL. In addition, the CvO bond of the polyester can be easily visualized after modification.…”

Section: Distribution Of Polymer In Woodmentioning

confidence: 79%

Fully biodegradable modification of wood for improvement of dimensional stability and water absorption properties by poly(ε-caprolactone) grafting into the cell walls

et al. 2014

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Materials derived from renewable resources are highly desirable in view of more sustainable manufacturing. Among the available natural materials, wood is one of the key candidates, because of its excellent mechanical properties. However, wood and wood-based materials in engineering applications suffer from various restraints, such as dimensional instability upon humidity changes. Several wood modification treatments increase water repellence, but the insertion of hydrophobic polymers can result in a composite material which cannot be considered as renewable anymore. In this study, we report on the grafting of the fully biodegradable poly(ε-caprolactone) (PCL) inside the wood cell walls by Sn(Oct) 2 catalysed ring-opening polymerization (ROP). The presence of polyester chains within the wood cell wall structure is monitored by confocal Raman imaging and spectroscopy as well as scanning electron microscopy. Physical tests reveal that the modified wood is more hydrophobic due to the bulking of the cell wall structure with the polyester chains, which results in a novel fully biodegradable wood material with improved dimensional stability.

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Section: Distribution Of Polymer In Woodmentioning

confidence: 79%

Fully biodegradable modification of wood for improvement of dimensional stability and water absorption properties by poly(ε-caprolactone) grafting into the cell walls

et al. 2014

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“…45,46 In CL spectrum, the bands at 1,650-1,500 cm -1 are due to the C=C stretching vibrations, and the intense absorption peak at 1,445 cm -1 , related to the axial deformation of C=O of carboxylic acid, is also consistent with the OH deformation in carboxylic acid. Moreover, the peak registered at 1,385 cm -1 is attributed to C-H symmetric deformation of CH 3 .…”

Section: Characterization Of Npsmentioning

confidence: 86%

Nanoencapsulation of natural triterpenoid celastrol for prostate cancer treatment

Sanna¹,

Chamcheu²,

Pala³

et al. 2015

IJN

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Celastrol (CL), a triterpenoid extracted from the Chinese herb Tripterygium wilfordii , has recently attracted interest for its potential antitumor effects. However, unfavorable physicochemical and pharmacokinetics properties such as low solubility, poor bioavailability, and systemic toxicity, are limiting its therapeutic application. In this context, the development of innovative nanocarriers can be useful to overcome these issues, and nanoencapsulation would represent a powerful strategy. In this study, we developed novel CL-loaded poly( ε -caprolactone) nanoparticles (NPs), and investigated their antiproliferative efficacy on prostate cancer cells. CL-NPs were prepared using a nanoprecipitation method and fully characterized by physicochemical techniques. The antiproliferative effects on LNCaP, DU-145, and PC3 cell lines of CL-NPs, compared to those of free CL at different concentrations (0.5, 1.0, and 2.0 µM), were investigated. Moreover, fluorescence microscopy was utilized to examine the cellular uptake of the nanosystems. Furthermore, to elucidate impact of nanoencapsulation on the mechanism of action, Western analyses were conducted to explore apoptosis, migration, proliferation, and angiogenesis alteration of prostate cancer cells. The results confirmed that CL-NPs inhibit proliferation dose dependently in all prostate cancer cells, with inhibitory concentration 50 less than 2 µM. In particular, the NPs significantly increased cytotoxicity at lower/medium dose (0.5 and 1.0 µM) on DU145 and PC3 cell lines with respect to free CL, with modulation of apoptotic and cell cycle machinery proteins. To date, this represents the first report on the development of biocompatible polymeric NPs encapsulating CL. Our findings offer new perspectives for the exploitation of developed CL-NPs as suitable prototypes for prostate cancer treatment.

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“…The crystalline properties of a material are important when considering the material for medical applications because the crystalline properties of a polymer have a direct bearing upon the degradation behavior in vivo [19,[31][32][33]. A high or low degradation rate may be desirable, depending on the application of the material.…”

Section: Introductionmentioning

confidence: 99%

Tailoring Crystallinity of Electrospun Plla Fibres by Control of Electrospinning Parameters

2012

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Poly(L-lactic acid) (PLLA) fibers were fabricated by electrospinning. The effects of various electrospinning process parameters on the thermal properties, especially the crystallinity of the electrospun fibers were investigated. Thermal analysis of the fibers revealed that they exhibited degree of crystallinity ranging from 23% to 46% while that for the as-received granules was approximately 37%, suggesting that the crystallinity of electrospun PLLA fibres can be controlled by optimizing the electrospinning process. This finding is very important because crystallinity affects polymer properties such as degradation, stiffness, yield stress, modulus and tensile strength, solubility, optical and electrical properties which will in turn affect the behavior of these materials when they are utilized in energy, environment, defense and security applications. The results presented in this paper show that the degree of crystallinity of the electrospun fibers decreased with increasing the polymer solution concentration. Furthermore, an optimum electrospinning voltage at which maximum degree of crystallinity can be obtained was observed. At voltages higher or lower than the optimum electrospinning voltage, the degree of crystallinity will decrease or increase, respectively. The effect of the needle tip to collector distance (NTCD) on the degree of crystallinity follows no predictable and consistent pattern.

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Structural characterization and hydrolytic degradation of solid copolymers of d,l-lactide-co-ε-caprolactone by Raman spectroscopy

Cited by 145 publications

References 9 publications

Fully biodegradable modification of wood for improvement of dimensional stability and water absorption properties by poly(ε-caprolactone) grafting into the cell walls

Fully biodegradable modification of wood for improvement of dimensional stability and water absorption properties by poly(ε-caprolactone) grafting into the cell walls

Nanoencapsulation of natural triterpenoid celastrol for prostate cancer treatment

Tailoring Crystallinity of Electrospun Plla Fibres by Control of Electrospinning Parameters

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