Structural Characterization and Digestibility of Curcumin Loaded Octenyl Succinic Nanoparticles

Abstract

Curcumin displays anti-cancer, anti-inflammatory and anti-obesity properties but its water insolubility limits the wholesome utility. In this study, curcumin has been encapsulated in an amphiphilic biopolymer to enhance its water solubility. This was accomplished through self-assembly of octenyl succinic anhydride–short glucan chains (OSA–SGC) and curcumin. The nanoparticles were prepared with the degree of substitution (DS) of 0.112, 0.286 and 0.342 of OSA. Thus prepared nanoparticles were in the range of 150–200 nm and display high encapsulation efficiency and high loading capacity of curcumin. The Fourier-transform infrared (FTIR) and X-ray diffraction analyses confirmed the curcumin loading in the OSA–SGC nanoparticles. The complexes possessed a V-type starch structure. The thermo gravimetric analysis (TGA) revealed the thermal stability of encapsulated curcumin. The OSA–SGC nanoparticles greatly improved the curcumin release and dissolution, and in-turn promoted the sustained release.

Fabrication and characterization of octenyl succinic anhydride modified pullulan micelles for encapsulating curcumin

“…According to the releasing curves of free curcumin reported by Yang et al ., 77 free curcumin exhibited a burst release of 55.18% over 2 h in SGF, followed by a sustained release of 26.82% within 4 h in SIF. Similar results were also reported by Mohamed et al 69 . and Liu et al 66 .…”

Polysaccharide Matrices for the Encapsulation of Tetrahydrocurcumin—Potential Application as Biopesticide against Fusarium graminearum

“…It took one day to reach the plateau with those particles. Hu et al [42] also reached a plateau of release for curcumin from spray-dried OSA-starch particles after one day. Curcumin was released faster, i.e., in two hours from chitosan spray-dried particles in other studies [38,40].…”

“…Curcumin, the phenolic compound from which THC is derived, has already been trapped into chitosan/Tween 20 spray-dried particles [38], chitosan/Tween 80 spray-dried particles [39] or spray-dried chitosan particles stabilized with the ionic tripolyphosphate linker [40,41]. Curcumin have also recently been loaded in OSA-starch freeze-dried particles [42]. In these examples, the encapsulation of actives has enabled a long-lasting release and a better efficiency.…”

Nanocomposites: Nanoscience and Nanotechnology (Nanoscale Phenomena) in Advanced Composites

“…This is with regard to any material property of the nanocomposites, be it related to crystallographic and/or electronic structure. In line with this theme, eight representative articles [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ] have been published in this Special Issue:…”

“…Critically for biomolecular design and drug delivery application, Feng et al [ 7 ] encapsulated typically water-insoluble curcumin in an amphiphilic biopolymer known as octenyl succinic anhydride–short glucan chains (OSA–SGC), using self-assembly, to form water-soluble curcumin–OSA–SGC nanoparticles. Curcumin displays anti-cancer, anti-inflammatory, and anti-obesity properties, but its water insolubility limits the wholesome utility.…”