Structural characterization and developability assessment of sustained release hydrogels for rapid implementation during preclinical studies

Agarwal, Prashant; Greene, Daniel G.; Sherman, Scott J.; Wendl, Kaitlyn; Vega, Leonela; Park, Hyunsoo; Shimanovich, Roman; Reid, Darren L.

doi:10.1016/j.ejps.2020.105689

Cited by 14 publications

(9 citation statements)

References 79 publications

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“…According to the literature, the observed drug release from PCLA thermosensitive hydrogels was controlled and prolonged for up to 30 days. In general, the release kinetics were close to first order, and matrix decomposition was observed during the experiments [ 3 , 64 ]. Li and coworkers [ 23 ] obtained the PCLA hydrogel as injectable flurbiprofen DDS.…”

Section: Resultsmentioning

confidence: 97%

“…Among the most promising types of DDSs are hydrogels—3D, crosslinked polymeric structures capable of absorbing large amounts of water or biological fluids while retaining integrity [ 2 ]. The primary benefits of using hydrogels as drug carriers include ease of manufacturing and administration, the ability to deliver a variety of drugs, and nearly 100% drug entrapment [ 3 ]. Stimuli-sensitive hydrogels, also known as smart hydrogels, can change their properties in response to external or internal stimuli such as temperature, pH, ionic strength, electromagnetic radiation, magnetic field, or biological factors (antibodies or enzymes) [ 2 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, amphiphilic macromolecules can act as a solubilizer for hydrophobic and insoluble drugs, significantly increasing their water solubility [ 15 ]. To date, a considerable amount of thermosensitive hydrogels based on PCL/poly(ethylene oxide) (PEG) [ 16 , 17 , 18 , 19 , 20 ], PLA/PEG [ 21 , 22 ], PCL/PLA/PEG [ 3 , 23 , 24 ], and PCL/PGA/PEG [ 25 , 26 ] block copolymers have been described in the literature as potential DDSs with attractive properties.…”

Section: Introductionmentioning

confidence: 99%

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Dual-Stimuli-Sensitive Smart Hydrogels Containing Magnetic Nanoparticles as Antitumor Local Drug Delivery Systems—Synthesis and Characterization

Kasiński

Świerczek

Zielińska–Pisklak

et al. 2023

IJMS

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The aim of this study was to develop an innovative, dual-stimuli-responsive smart hydrogel local drug delivery system (LDDS), potentially useful as an injectable simultaneous chemotherapy and magnetic hyperthermia (MHT) antitumor treatment device. The hydrogels were based on a biocompatible and biodegradable poly(ε-caprolactone-co-rac-lactide)-b-poly(ethylene glycol)-b-poly(ε-caprolactone-co-rac-lactide) (PCLA-PEG-PCLA, PCLA) triblock copolymer, synthesized via ring-opening polymerization (ROP) in the presence of a zirconium(IV) acetylacetonate (Zr(acac)4) catalyst. The PCLA copolymers were successfully synthesized and characterized using NMR and GPC techniques. Furthermore, the gel-forming and rheological properties of the resulting hydrogels were thoroughly investigated, and the optimal synthesis conditions were determined. The coprecipitation method was applied to create magnetic iron oxide nanoparticles (MIONs) with a low diameter and a narrow size distribution. The magnetic properties of the MIONs were close to superparamagnetic upon TEM, DLS, and VSM analysis. The particle suspension placed in an alternating magnetic field (AMF) of the appropriate parameters showed a rapid increase in temperature to the values desired for hyperthermia. The MIONs/hydrogel matrices were evaluated for paclitaxel (PTX) release in vitro. The release was prolonged and well controlled, displaying close to zero-order kinetics; the drug release mechanism was found to be anomalous. Furthermore, it was found that the simulated hyperthermia conditions had no effect on the release kinetics. As a result, the synthesized smart hydrogels were discovered to be a promising antitumor LDDS, allowing simultaneous chemotherapy and hyperthermia treatment.

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Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dual-Stimuli-Sensitive Smart Hydrogels Containing Magnetic Nanoparticles as Antitumor Local Drug Delivery Systems—Synthesis and Characterization

Kasiński

Świerczek

Zielińska–Pisklak

et al. 2023

IJMS

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“…When performing injection force measurements, there was an initial increase in force during start up, and then the force plateaued (Figure S16). The initial increase in force is attributed to friction during start up, whereas the plateau is characterized as a “glide force” representative of the material being injected . The injection force reported below is the plateau force over a 10 s interval.…”

Section: Resultsmentioning

confidence: 99%

“…The initial increase in force is attributed to friction during start up, 74 whereas the plateau is characterized as a "glide force" representative of the material being injected. 75 The injection force reported below is the plateau force over a 10 s interval. For a given cross-linking chemistry, an increase in a hydrogel's polymeric concentration resulted in an increased injection force (Figure 6b).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Shear Thickening Behavior in Injectable Tetra-PEG Hydrogels Cross-Linked via Dynamic Thia-Michael Addition Bonds

Crowell,

FitzSimons,

Anslyn

et al. 2023

Macromolecules

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Injectable poly(ethylene glycol) (PEG)-based hydrogels were reversibly cross-linked through thia-conjugate addition bonds and demonstrated to shear thicken at low shear rates. Cross-linking bond exchange kinetics and dilute polymer concentrations were leveraged to tune hydrogel plateau moduli (from 60 to 650 Pa) and relaxation times (from 2 to 8 s). Under continuous flow shear rheometry, these properties affected the onset of shear thickening and the degree of shear thickening achieved before a flow instability occurred. The changes in viscosity were reversible whether the shear rate increased or decreased, suggesting that chain stretching drives this behavior. Given the relevance of dynamic PEG hydrogels under shear to biomedical applications, their injectability was investigated. Injection forces were found to increase with higher polymer concentrations and slower bond exchange kinetics. Altogether, these results characterize the nonlinear rheology of dilute, dynamic covalent tetra-PEG hydrogels and offer insight into the mechanism driving their shear thickening behavior.

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PAAm/CMC/nanoclay nanocomposite hydrogel: understanding the influence of initiators on the chain-growth mechanisms

et al. 2022

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Structural characterization and developability assessment of sustained release hydrogels for rapid implementation during preclinical studies

Cited by 14 publications

References 79 publications

Dual-Stimuli-Sensitive Smart Hydrogels Containing Magnetic Nanoparticles as Antitumor Local Drug Delivery Systems—Synthesis and Characterization

Dual-Stimuli-Sensitive Smart Hydrogels Containing Magnetic Nanoparticles as Antitumor Local Drug Delivery Systems—Synthesis and Characterization

Shear Thickening Behavior in Injectable Tetra-PEG Hydrogels Cross-Linked via Dynamic Thia-Michael Addition Bonds

PAAm/CMC/nanoclay nanocomposite hydrogel: understanding the influence of initiators on the chain-growth mechanisms

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