Structural characterization and antitumor activity of a polysaccharide from ramulus mori

Chen, Yajie; Jiang, Xue; Xie, Hongqing; Li, Xiaotong; Shi, Liangen

doi:10.1016/j.carbpol.2018.02.036

Cited by 112 publications

(45 citation statements)

References 38 publications

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“…To date, phytochemical studies and analytical method development have been conducted on various parts of M. alba , but few studies have compared active components of the various medicinal parts of M. alba (Chen, Jiang, Xie, Li, & Shi, ; Kim et al, ; Ma, Weng, & Liang, ; Xiao et al, ). For this study, we developed an HPLC method for the simultaneous quality control and discrimination of Cortex Mori, Ramulus Mori, Folium Mori and Fructus Mori using 13 marker compounds.…”

Section: Resultsmentioning

confidence: 99%

Comparative study of chemical composition and active components against α‐glucosidase of various medicinal parts of Morus alba L.

Chen

Yang

et al. 2018

Biomedical Chromatography

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Morus alba L has long been used as fodder and as a traditional medicine. The different parts of M. alba (Cortex Mori, Ramulus Mori, Folium Mori and Fructus Mori) have different bioactivities; however, most current evidence is focused on anti-diabetic properties. In spite of their widespread use, few studies have compared the chemical composition and activity against α-glucosidase of the various medicinal parts of M.alba. In this study, we developed an HPLC method for simultaneous quality control and discrimination of Cortex Mori, Ramulus Mori, Folium Mori and Fructus Mori using 13 marker compounds. We found that quercetin, morin, kuwanon G, sanggenon C, morusin, mulberroside A and rutin were chemically distinct among the various medicinal parts of M. alba. A spectrum-effect relationship method was established to compare α-glucosidase inhibitory activity of various batches of samples to determine the activity of the primary active components against α-glucosidase. Taken together with molecular docking data, we found that prenylated flavonoids (morin, sanggenon C, kuwanon G and morusin), flavonols (kaempferol, quercetin, rutin and isoquercitrin) and alkaloids (1-deoxynojirimycin) were small molecule α-glucosidase inhibitory ingredients. In conclusion, we laid a solid foundation for effective substance identification in various parts of M. alba, and simultaneously provided a basis for their quality control.

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Section: Resultsmentioning

confidence: 99%

Comparative study of chemical composition and active components against α‐glucosidase of various medicinal parts of Morus alba L.

Chen

Yang

et al. 2018

Biomedical Chromatography

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“…These cells can trigger a variety of reactions such as the expression of certain cytokines. Mulberry polysaccharides have an obvious anticancer effect on cancer cells [ 164 ]. The mechanism of polysaccharides in anti-cancer activity is not clearly understood, but the polysaccharides in regulating the immune system via intestinal fermentation is probably involved.…”

Section: Polysaccharides and Healthmentioning

confidence: 99%

Beneficial Effect of Intestinal Fermentation of Natural Polysaccharides

et al. 2018

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With the rapid development of modern society, many chronic diseases are increasing including diabetes, obesity, cardiovascular diseases, etc., which further cause an increased death rate worldwide. A high caloric diet with reduced natural polysaccharides, typically indigestible polysaccharides, is considered a health risk factor. With solid evidence accumulating that indigestible polysaccharides can effectively prevent and/or ameliorate symptoms of many chronic diseases, we give a narrative review of many natural polysaccharides extracted from various food resources which mainly contribute their health beneficial functions via intestinal fermentation.

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“…The weak absorption peaks at 2935 cm −1 and 2939 cm −1 were characteristic of C-H stretching vibration, and these bands above were characteristic absorption peaks of polysaccharides. The characteristic absorption band near 883 cm −1 indicated that RLP-1a, RLP-2a, and RLP-3a contained β -type glycosidic bond [ 30 ]. Moreover, near 1715 cm −1 without absorption further explained that no uronic acids existed in polysaccharides [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

Extraction and Hypolipidemic Activity of Low Molecular Weight Polysaccharides Isolated from Rosa Laevigata Fruits

Zhang

Jin

et al. 2020

BioMed Research International

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Three novel low molecular weight polysaccharides (RLP-1a, RLP-2a, and RLP-3a) with 9004, 8761, and 7571 Da were first obtained by purifying the crude polysaccharides from the fruits of a traditional Chinese medicinal herb Rosae Laevigatae. The conditions for polysaccharides from the R. Laevigatae fruit (RLP) extraction were optimized by the response surface methodology, and the optimal conditions were as follows: extraction temperature, 93°C; extraction time, 2.8 h; water to raw material ratio, 22; extraction frequency, 3. Structural characterization showed that RLP-1a consisted of rhamnose, arabinose, xylose, glucose, and galactose with the ratio of 3.14 : 8.21 : 1 : 1.37 : 4.90, whereas RLP-2a was composed of rhamnose, mannose, glucose, and galactose with the ratio of 1.70 : 1 : 93.59 : 2.73, and RLP-3a was composed of rhamnose, arabinose, xylose, mannose, glucose, and galactose with the ratio of 6.04 : 26.51 : 2.05 : 1 : 3.17 : 31.77. The NMR analyses revealed that RLP-1a, RLP-2a, and RLP-3a contained 6, 4, and 6 types of glycosidic linkages, respectively. RLP-1a and RLP-3a exhibited distinct antioxidant abilities on the superoxide anions, 1,1-diphenyl-2-picrylhydrazyl (DPPH), and hydroxyl radicals in vitro. RLPs could decrease the serum lipid levels, elevate the serum high-density lipoprotein cholesterol levels, enhance the antioxidant enzymes levels, and upregulate of FADS2, ACOX3, and SCD-1 which involved in the lipid metabolic processes and oxidative stress in the high-fat diet-induced rats. These results suggested that RLPs ameliorated the high-fat diet- (HFD-) induced lipid metabolism disturbance in the rat liver through the peroxisome proliferator-activated receptor (PPAR) signaling pathway. Low molecular weight polysaccharides of RLP could be served as a novel potential functional food for improving hyperlipidemia and liver oxidative stress responses.

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Structural characterization and antitumor activity of a polysaccharide from ramulus mori

Cited by 112 publications

References 38 publications

Comparative study of chemical composition and active components against α‐glucosidase of various medicinal parts of Morus alba L.

Comparative study of chemical composition and active components against α‐glucosidase of various medicinal parts of Morus alba L.

Beneficial Effect of Intestinal Fermentation of Natural Polysaccharides

Extraction and Hypolipidemic Activity of Low Molecular Weight Polysaccharides Isolated from Rosa Laevigata Fruits

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