Structural Characterization and Antidepressant-Like Effects of <em>Polygonum sibiricum </em>Polysaccharides Associated with Regulating Microglial Polarization in Cums-Induced Zebrafish
Ying yu Zhang,
Dan yang Wang,
Jia meng Liu
et al.
Abstract:: Background: The polysaccharides are one of the main active ingredients of Polygonum sibiricum (PSP), which is a traditional food and medicine homologues in China. The antidepressant-like effects of PSP and its underlying mechanisms remain to be studied in depth, especially the regulation of microglial polarization. Methods: The chemical composition and structural characteristics of PSP was determined firstly. The CUMS procedure was carried out to the zebrafish for 5 weeks and PSP were immersed administration… Show more
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