Structural characterization and anti-inflammatory potential of sulfated polysaccharides from Scytosiphon lomentaria; attenuate inflammatory signaling pathways

Jayawardhana, H.H.A.C.K.; Lee, Hyo-Geun; Liyanage, N.M.; Nagahawatta, D.P.; Ryu, BoMi; Jeon, You‐Jin

doi:10.1016/j.jff.2023.105446

Cited by 15 publications

(8 citation statements)

References 46 publications

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“…Furthermore, ERK, JNK, and p38 are important integrators in pharmacological therapy for inflammatory disorders. Multiple studies have shown that LPS can activate the MAPK signaling pathway by phosphorylating MAPK proteins [ 8 ]. Our results revealed that F5 downregulated the expression of MAPK pathway proteins in LPS-stimulated RAW 264.7 cells.…”

Section: Discussionmentioning

confidence: 99%

“…The detection waveform of the detector was set at 0.05 potential waveform. Standard mixtures (fucose, rhamnose, arabinose, galactose, glucose, xylose, and fructose) were injected as described above [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

“…Most earlier studies have reported that the sulfated polysaccharide fucoidan from brown seaweeds possesses multifunctional, non-toxic, and highly biocompatible polymers [ 7 ]. Fucoidans from different marine algae have many multifunctional bioactivities, including anti-inflammatory, antitumor, antioxidant, pro-immune, and antiviral effects [ 8 , 9 , 10 , 11 ]. Enzymatic extraction is thought to be more advantageous than the traditional techniques for extracting bioactive compounds from seaweeds, including microwave-assisted extraction, ultrasound-assisted extraction, supercritical fluid extraction, and pressurized liquid extraction [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Physical Characteristics and In Vitro Anti-Inflammatory Effects of Fucoidan from Padina arborescens: A Comprehensive Assessment against Lipopolysaccharide-Induced Inflammation

Lee,

Liyanage,

Yang

et al. 2024

Marine Drugs

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A biocompatible, heterogeneous, fucose-rich, sulfated polysaccharide (fucoidan) is biosynthesized in brown seaweed. In this study, fucoidan was isolated from Padina arborescens (PAC) using celluclast-assisted extraction, purified, and evaluated for its anti-inflammatory potential in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Structural analyses were performed using Fourier transform infrared (FTIR) and scanning electron microscopy. Among the purified fucoidans, fucoidan fraction 5 (F5) exhibited strong inhibitory activity against LPS-induced nitric oxide (NO) production and pro-inflammatory cytokine generation through the regulation of iNOS/COX-2, MAPK, and NF-κB signaling in LPS-induced RAW 264.7 cells. Determination of the structural characteristics indicated that purified F5 exhibited characteristics similar to those of commercial fucoidan. In addition, further analyses suggested that F5 inhibits LPS-induced toxicity, cell death, and NO generation in zebrafish models. Taken together, these findings imply that P. arborescens fucoidans have exceptional anti-inflammatory action, both in vitro and in vivo, and that they may have prospective uses in the functional food sector.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigation of Physical Characteristics and In Vitro Anti-Inflammatory Effects of Fucoidan from Padina arborescens: A Comprehensive Assessment against Lipopolysaccharide-Induced Inflammation

Lee,

Liyanage,

Yang

et al. 2024

Marine Drugs

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“…Polysaccharides generated from algae have been widely used in various medicinal applications owing to their potential use in pharmaceuticals, their biodegradability, and their biocompatibility [ 20 , 21 ]. Algal polysaccharides are essential for many biological processes, including cell–cell communication, cell growth, and immune system molecular recognition.…”

Section: Sulfated Polysaccharides From Marine Algaementioning

confidence: 99%

Sulfated Polysaccharides from Seaweeds: A Promising Strategy for Combatting Viral Diseases—A Review

Liyanage,

Nagahawatta,

Jayawardena

et al. 2023

Marine Drugs

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The limited availability of treatments for many infectious diseases highlights the need for new treatments, particularly for viral infections. Natural compounds from seaweed are attracting increasing attention for the treatment of various viral diseases, and thousands of novel compounds have been isolated for the development of pharmaceutical products. Seaweed is a rich source of natural bioactive compounds, including polysaccharides. The discovery of algal polysaccharides with antiviral activity has significantly increased in the past few decades. Furthermore, unique polysaccharides isolated from seaweeds, such as carrageenan, alginates, fucoidans, galactans, laminarians, and ulvans, have been shown to act against viral infections. The antiviral mechanisms of these agents are based on their inhibition of DNA or RNA synthesis, viral entry, and viral replication. In this article, we review and provide an inclusive description of the antiviral activities of algal polysaccharides. Additionally, we discuss the challenges and opportunities for developing polysaccharide-based antiviral therapies, including issues related to drug delivery and formulation. Finally, this review highlights the need for further research for fully understanding the potential of seaweed polysaccharides as a source of antiviral agents and for developing effective treatments for viral diseases.

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“…This comprehensive review elucidates the multifaceted biological activities and ence key biological functions and modulate them to play beneficial roles in prominent biological functions such as antioxidation, inflammation, coagulation, viral infection, and wound healing (Costa et al 2010, Little et al 2021. Moreover, SPs serve as multifunctional molecules that can facilitate a wide range of biological activities, making them valuable in various industries, such as medicine, pharmaceuticals, cosmeceuticals, and functional food (Hayashi et al 2008, Jayawardhana et al 2023, Liyanage et al 2023a). These beneficial outcomes make seaweed a valuable resource for numerous industrial and scientific research.…”

Section: Introductionmentioning

confidence: 99%

Functions and values of sulfated polysaccharides from seaweed

Nagahawatta,

Liyanage,

Jayawardena

et al. 2023

Algae

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Sulfated polysaccharides (SPs) isolated from seaweed have emerged as remarkable bioactive compounds with a wide spectrum of biological activities and have substantial value in the scientific and industrial domains. The current study explores the diverse biological activities of SPs and their relationship with their structures. This aids in an in-depth examination of the multifaceted biological activities of SPs, including anticoagulant, anti-inflammatory, antiviral, antioxidant, and immunomodulatory properties, which underpin their potential health benefits. Furthermore, the current study explores the complicated properties of SPs, with their extraction methodologies and techniques for precise characterization. Elucidation of the commercial significance of SPs derived from brown, red, and green seaweed by highlighting their potential applications has emphasized their importance in human well-being. Further, this review emphasizes the challenges needed to overcome research and industrial innovations for SPs. Collaboration among researchers, industry stakeholders, and regulatory authorities can overcome these challenges and elevate the potential of SPs to revolutionize industries such as pharmaceuticals, cosmeceuticals, food, and biotechnology.

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Structural characterization and anti-inflammatory potential of sulfated polysaccharides from Scytosiphon lomentaria; attenuate inflammatory signaling pathways

Cited by 15 publications

References 46 publications

Investigation of Physical Characteristics and In Vitro Anti-Inflammatory Effects of Fucoidan from Padina arborescens: A Comprehensive Assessment against Lipopolysaccharide-Induced Inflammation

Investigation of Physical Characteristics and In Vitro Anti-Inflammatory Effects of Fucoidan from Padina arborescens: A Comprehensive Assessment against Lipopolysaccharide-Induced Inflammation

Sulfated Polysaccharides from Seaweeds: A Promising Strategy for Combatting Viral Diseases—A Review

Functions and values of sulfated polysaccharides from seaweed

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