Structural characterization and anti-fatigue activity of polysaccharides from the roots of Morinda officinalis

Zhang, Hualin; Li, Jun; Li, George; Wang, Dongmei; Zhu, Long‐Ping; Yang, Dongzi

doi:10.1016/j.ijbiomac.2008.12.010

Cited by 71 publications

(35 citation statements)

References 27 publications

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“…However, no significant differences were observed between AVII and SWBII with respect to body weight and weight gain of mice. Similar result of increased body weight in mice was also observed due to feeding of watersoluble polysaccharides from Morinda officinalis (Zhang et al, 2009).…”

Section: In Vivo Evaluation In Swiss Micesupporting

confidence: 74%

Development of Poly Herbal Granules and its Anti-Fatigue Efficacy in Swiss Mice

Devi¹,

Nalwade²,

Rajurkar³

2017

Int.J.Curr.Microbiol.App.Sci

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The current study sought to investigate the anti-fatigue efficacy of poly herbal granule (PHG) formulations of the extracts of Asparagus racemosus, Chlorophytum borivilianum, Tinospora cordifolia, Tribulus terrestris and Withania somnifera enriched with general tonic and health promoting properties based on Aloe vera gel and soyabean whey in Swiss mice. The nutrient compositions of the selected PHG exhibited that the carbohydrates were the major constituents in both AVII and SBWII, followed by protein and total ash. Fat contents were 0.96 and 1.18 g100g -1 in AVII and SBWII, respectively. The energy levels of AVII and SBWII were 378 and 377 kcal100g -1 , correspondingly. Higher contents of Ca (70.20 mg100g -1 ), Mg (85.27mg100g -1 ) and P (61.55 mg100g -1 ) were observed in SBWII. The trace elements revealed that, Zn and Fe content were 1.84 and 8.63mg100g-1 in AVII and 1.85 and 7.85mg100g -1 in SBWII, respectively. The retention and stability of Vitamin C, total sugar, reducing sugar and non-reducing sugar for 270 days illustrated the storage life of the product in ambient condition. The body weight of mice, swimming time and corresponding biochemical parameters including haemoglobin, serum protein and blood glucose level were measured by standard method. The oral administration with PHG supplement for 30 days markedly increased the body weight (11.40-11.80%), haemoglobin (11.82-12.46%), serum protein (3.77-6.02%) of the mice. Following forced swimming test (FST), prolonged exhaustive exercise time of 231.02 (AVII), 237.50 (SBWII) minutes were recorded for PHG supplemented groups which were 36.23 (AVII) and 37.97 (SBWII) per cent longer than that of the control group. The minute increase of blood glucose levels (4.51-4.37%) in PHG supplemented Swiss mice after FST as compared to tremendous increase in blood glucose level (40.07%) in the control group illustrated the anti-fatigue activity of PHG. K e y w o r d s

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Section: In Vivo Evaluation In Swiss Micesupporting

confidence: 74%

Development of Poly Herbal Granules and its Anti-Fatigue Efficacy in Swiss Mice

Devi¹,

Nalwade²,

Rajurkar³

2017

Int.J.Curr.Microbiol.App.Sci

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“…[24][25][26] Saponins and polysaccharides isolated from natural products have anti-fatigue activity: saponins from Astragalus membranaceus and Panax ginseng and polysaccharides from Morinda officinalis and Radix Rehmanniae Preparata exhibit the anti-fatigue activities. 18,[27][28][29] Ginseng has been used for a long time in Asian countries to treat many disorders, including aging, fatigue, stress, tumor, and insomnia. 16,30) Its bioactive constituents are saponins, polysaccharides, and proteins.…”

Section: Discussionmentioning

confidence: 99%

Anti-fatigue Effects of 20(<i>S</i>)-Protopanaxadiol and 20(<i>S</i>)-Protopanaxatriol in Mice

Kim²,

Choi

et al. 2015

Biological & Pharmaceutical Bulletin

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Ginseng (Panax ginseng C.A. MEYER, Araliaceae), which contains protopanaxadiol-type and protopanaxatriol-type ginsenosides, has been used for inflammation, fatigue, stress, and tumor in Asian countries. Orally administered ginsenosides are metabolized to their aglycones 20(S)-protopanaxadiol (PPD) and 20(S)-protopanaxatriol (PPT) by gut microbiota. However, their anti-fatigue effects have not been studied thoroughly. Therefore, we investigated the anti-fatigue activities of PPD and PPT in mice, using the weightloaded swimming (WLS) and the rota-rod tests. Ginseng water extract (GW), ginseng saponin fraction (GWS) and ginseng polysaccharide fraction (GWP) at concentrations of 50 and 100 mg/kg and PPD and PPT at 5 and 10 mg/kg were orally administered to mice once daily for 5 d. GW, GWS, and PPT significantly increased the WLS time, however, GWP and PPD did not cause any significant change. PPT induced the most significant increase in WLS time. PPD (10 mg/kg) and PPT (5 and 10 mg/kg) inhibited the WLS-induced increase in corticosterone, lactate, lactate dehydrogenase (LDH), and creatinine levels as well as the reduction in glucose level. PPT increased the riding time in the rota-rod test, and also inhibited corticosterone, lactate, and creatinine levels. These findings suggest that the anti-fatigue effect of ginseng may be attributable to its saponins, particularly PPT, rather than to its polysaccharides. Key words Panax ginseng; 20(S)-protopanaxadiol; 20(S)-protopanaxatriol; fatigueFatigue is described as the lack of energy and motivation to initiate and sustain voluntary physical and mental activities.1) Physical fatigue is the transient inability of a muscle to maintain physical performance and is made more severe by physical stress. Mental fatigue is a transient decrease in cognitive performance. Most cases of fatigue may be attributed to lifestyle factors such as alcohol abuse and excessive physical activity, medical conditions such as multiple sclerosis and Parkinson's disease, or psychological problems such as anxiety and stress. Therefore, natural products including ginseng have been studied with the aim of developing anti-fatigue drugs to improve athletic ability, delay fatigue, and enhance the elimination of fatigue in humans. [2][3][4][5][6] Ginseng (the root of Panax ginseng C.A. MEYER, Araliaceae) has been widely used as a traditional Chinese medicine for enhancing body strength, recovering physical balance, and stimulating metabolic function in Asian countries. It contains various active constituents such as ginsenosides, polysaccharides, polyacetylenes, phenolic compounds, and peptides. 7)Of constituents, ginsenosides have been reported to show biological activities, including anti-inflammatory, anti-fatigue, anti-stress, and anti-tumor activities. [8][9][10][11][12] The ginsenosides are classified as protopanaxadiols or protopanaxatriols. Orally administered protopanaxadiol-type and protopanaxatriol-type ginsenosides are metabolized to 20(S)-protopanaxadiol (PPD) via compound K and 20(S)-protopanax...

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“…3.5 g of crude polysaccharide was obtained. The obtained polysaccharide were dissolved in 500 ml of water and deproteinized according to the previous reports [13]. The deproteinized crude polysaccharide solution was precipitated with 95% (v/v) ethanol for 12 h at 4 • C. The precipitate was lyophilized, and about 1 g of polysaccharide was obtained.…”

Section: Chemicals and Materialsmentioning

confidence: 99%

“…13 C NMR (a) and DEPT (b) spectra of API in D2O at room temperature (500 mHz).carbons of residue →2)-␣-d-glucopyranyl-(1→, residue 3-O-(␣-dxylofuranlyl), residue →2)-␣-d-galactopyranyl-(1→, respectively.The other chemical shifts are also listed in…”

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confidence: 99%