Structural characteristics of sulfated polysaccharides from <i>Sargassum horneri</i> and immune-enhancing activity of polysaccharides combined with lactic acid bacteria

Kim, Young-Sang; Hwang, Jin; Lee, Sang Gil; Jo, Hee Young; Oh, Myung Jin; Liyanage, N.M.; Je, Jun-Geon; An, Hyun Joo; Jeon, You‐Jin

doi:10.1039/d1fo03946f

Cited by 6 publications

(5 citation statements)

References 59 publications

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“…In the present study, we established that F5 reduced LPS-induced NO generation. Our findings are consistent with those of earlier investigations on Chnoospora-minima - and Sargassum-swartzii -derived fucoidans [ 27 , 28 ].…”

Section: Discussionsupporting

confidence: 94%

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Investigation of Physical Characteristics and In Vitro Anti-Inflammatory Effects of Fucoidan from Padina arborescens: A Comprehensive Assessment against Lipopolysaccharide-Induced Inflammation

Lee,

Liyanage,

Yang

et al. 2024

Marine Drugs

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A biocompatible, heterogeneous, fucose-rich, sulfated polysaccharide (fucoidan) is biosynthesized in brown seaweed. In this study, fucoidan was isolated from Padina arborescens (PAC) using celluclast-assisted extraction, purified, and evaluated for its anti-inflammatory potential in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Structural analyses were performed using Fourier transform infrared (FTIR) and scanning electron microscopy. Among the purified fucoidans, fucoidan fraction 5 (F5) exhibited strong inhibitory activity against LPS-induced nitric oxide (NO) production and pro-inflammatory cytokine generation through the regulation of iNOS/COX-2, MAPK, and NF-κB signaling in LPS-induced RAW 264.7 cells. Determination of the structural characteristics indicated that purified F5 exhibited characteristics similar to those of commercial fucoidan. In addition, further analyses suggested that F5 inhibits LPS-induced toxicity, cell death, and NO generation in zebrafish models. Taken together, these findings imply that P. arborescens fucoidans have exceptional anti-inflammatory action, both in vitro and in vivo, and that they may have prospective uses in the functional food sector.

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Section: Discussionsupporting

confidence: 94%

“…FTIR spectra were observed between 500 and 3500 cm −1 . The spectrum of each sample was recorded, examined, and compared with that of commercially available fucoidan [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

Investigation of Physical Characteristics and In Vitro Anti-Inflammatory Effects of Fucoidan from Padina arborescens: A Comprehensive Assessment against Lipopolysaccharide-Induced Inflammation

Lee,

Liyanage,

Yang

et al. 2024

Marine Drugs

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“…Anionic polymers include sulfated polysaccharides. These macromolecules in algae play vital supporting and protective roles in the cell wall, enhancing pathogen recognition, moisture management, and high ionic strength in marine conditions [ 27 ]. These characteristics enable them to perform biological functions, including antiviral activity.…”

Section: Sulfated Polysaccharides From Marine Algaementioning

confidence: 99%

Sulfated Polysaccharides from Seaweeds: A Promising Strategy for Combatting Viral Diseases—A Review

Liyanage,

Nagahawatta,

Jayawardena

et al. 2023

Marine Drugs

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The limited availability of treatments for many infectious diseases highlights the need for new treatments, particularly for viral infections. Natural compounds from seaweed are attracting increasing attention for the treatment of various viral diseases, and thousands of novel compounds have been isolated for the development of pharmaceutical products. Seaweed is a rich source of natural bioactive compounds, including polysaccharides. The discovery of algal polysaccharides with antiviral activity has significantly increased in the past few decades. Furthermore, unique polysaccharides isolated from seaweeds, such as carrageenan, alginates, fucoidans, galactans, laminarians, and ulvans, have been shown to act against viral infections. The antiviral mechanisms of these agents are based on their inhibition of DNA or RNA synthesis, viral entry, and viral replication. In this article, we review and provide an inclusive description of the antiviral activities of algal polysaccharides. Additionally, we discuss the challenges and opportunities for developing polysaccharide-based antiviral therapies, including issues related to drug delivery and formulation. Finally, this review highlights the need for further research for fully understanding the potential of seaweed polysaccharides as a source of antiviral agents and for developing effective treatments for viral diseases.

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“…8 Kim et al have found that polysaccharides from Sargassum horneri showed potent immune-enhancing activity in combination with Lactobacillus plantarum. 9 Thus, synbiotics are further studied for their application in food production and clinical treatment. However, there are still fewer studies on sulfated polysaccharides from sea cucumber Stichopus japonicus (SCSPsj) as a component in synbiotics.…”

Section: Introductionmentioning

confidence: 99%

Sea cucumber sulfated polysaccharides and Lactobacillus gasseri synergistically ameliorate the overweight induced by altered gut microbiota in mice

Liu

Lin

et al. 2023

Food Funct.

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Structural characteristics of sulfated polysaccharides from Sargassum horneri and immune-enhancing activity of polysaccharides combined with lactic acid bacteria

Abstract: Sargassum horneri (SH), which has been distributed along the coast of China has flowed and invaded into Korea, causing great damage from 2015. For the sustainable strategy to control of...

Cited by 6 publications

References 59 publications

Investigation of Physical Characteristics and In Vitro Anti-Inflammatory Effects of Fucoidan from Padina arborescens: A Comprehensive Assessment against Lipopolysaccharide-Induced Inflammation

Investigation of Physical Characteristics and In Vitro Anti-Inflammatory Effects of Fucoidan from Padina arborescens: A Comprehensive Assessment against Lipopolysaccharide-Induced Inflammation

Sulfated Polysaccharides from Seaweeds: A Promising Strategy for Combatting Viral Diseases—A Review

Sea cucumber sulfated polysaccharides and Lactobacillus gasseri synergistically ameliorate the overweight induced by altered gut microbiota in mice

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