Structural characteristics of measles virus entry

Fukuhara, Hideo; Mwaba, Mwila Hilton; Maenaka, Katsumi

doi:10.1016/j.coviro.2020.04.002

Cited by 17 publications

(11 citation statements)

References 53 publications

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“…Compared with traditional structural forms (such as shell structure and truss skin structure), the reinforcing ribs of grid structure are relatively independent, and under the impact load, one rib is damaged, cracks are not easy to propagate, and the overall performance is good [ 9 , 10 ]. Fukuhara et al simulate the skin and ribs of the grid structure based on the laminated plate and laminated beam elements under Mindlin's first-order shear deformation theory [ 11 ]. Through the spatial coordinate transformation and using the geometric continuity conditions of the skin and ribs, the element tangent stiffness matrix of the composite smart grid structure is obtained, and the buckling finite element numerical simulation method of the composite smart grid structure is given.…”

Section: Related Workmentioning

confidence: 99%

Study on Structural Characteristics of Composite Smart Grille Based on Principal Component Analysis

Kong

Huazhong

Xie

2022

Computational Intelligence and Neuroscience

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In recent years, many scholars have conducted in-depth and extensive research on the mechanical properties, preparation methods, and structural optimization of grid structural materials. In this paper, the structural characteristics of composite intelligent grid are studied by combining theoretical analysis with experiments. According to the existing conditions in the laboratory, the equilateral triangular grid structure experimental pieces were prepared. In this paper, principal component analysis combined with nearest neighbor method was used to detect the damage of composite plates. On this basis, the multiobjective robustness optimization of the structure is carried out based on artificial intelligence algorithm, which makes the structure quality and its sensitivity to uncertain parameters lower. Particle swarm optimization (PSO) is used in neural network training. The damage characteristics of different grid structures, different impact positions, and different impact energies were studied. The results show that the structural damage types, areas, and propagation characteristics are very different when the structure is impacted at different positions, which verifies that the grid structure has a good ability to limit the damage diffusion and shows that the grid structure has a good ability to resist damage.

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Section: Related Workmentioning

confidence: 99%

Study on Structural Characteristics of Composite Smart Grille Based on Principal Component Analysis

Kong

Huazhong

Xie

2022

Computational Intelligence and Neuroscience

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“…16 La Organización Mundial de la Salud (OMS) actualmente reconoce 8 clados (A, B1-3, C1-3, D1-11, E, F, G1-3 y H1-2) de 24 genotipos, según las secuencias de nucleótidos de la hemaglutinina (H) y genes de nucleoproteína (N) de VS, y designa 6 de estos genotipos (B3, D4, D8, D9, G3 y H1) como activos. 17 Esta diversidad se refleja en los 24 genotipos del VS conocidos hasta la fecha (A, B1, B2, B3, C1, C2, D1, D2, D3, D4, D5, D6, D7, D8, D9, D10, D11, E, F, G1, G2, G3, H1 y H2). Sin embargo, entre octubre de 2017 y septiembre de 2018 la OMS sólo reportó cinco de estos genotipos (B3, D4, D8, D9 y H1).…”

Section: Virología Del Sarampiónunclassified

Perspectiva clínico-epidemiológica actual del sarampión en México

Bautista-Montiel

Paz-Bautista

Ortiz

2022

ICSA

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El sarampión es una enfermedad eruptiva, de predominio clínico en la infancia, causada por el virus del sarampión, un virus ARN de cadena negativa del género Morbillivirus y de la familia Paramyxoviridae. En México la primera epidemia ocurrió posterior a la conquista en el año 1531 y a partir de 1970 se introdujo la vacuna en el país. En 2020 se reportaron 196 casos que dispararon las alarmas epidemiológicas nacionales e internacionales. El curso clínico va de los 17 a 21 días, iniciando con un periodo de latencia de 10 a 14 días y un pródromo de 2 a 3 días de fiebre, coriza, tos y conjuntivitis, seguido de la aparición de una erupción maculopapular, los pacientes se consideran infecciosos 4 días antes o 4 días después de este punto de tiempo y su eliminación es compleja. El objetivo del presente estudio fue analizar la literatura internacional y forjar un panorama amplio sobre el conocimiento actual sobre el sarampión, ofreciendo al personal de salud un recorrido histórico y un panorama clínico-epidemiológico que coadyuve en la continuación y fortalecimiento de los programas de vigilancia epidemiológica y vacunación que se desarrollan en el territorio nacional.

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“…The replication cycle of nsNSV takes place in the cytoplasm of the host cell, with the exception of Bornaviruses that have a nuclear phase during their replication [72]. Entry of the virus is mediated by the attachment and binding of the surface protein to its receptor and fusion of the viral with the cellular membrane [73][74][75] (Figure 2C). Subsequently, the viral RNP is released into the cytoplasm of the cell.…”

Section: Viral Replication Cycle Of Negative Strand Rna Viruses (Nsv)mentioning

confidence: 99%

New Perspectives on the Biogenesis of Viral Inclusion Bodies in Negative-Sense RNA Virus Infections

Dolnik

Gerresheim

Biedenkopf

2021

Cells

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Infections by negative strand RNA viruses (NSVs) induce the formation of viral inclusion bodies (IBs) in the host cell that segregate viral as well as cellular proteins to enable efficient viral replication. The induction of those membrane-less viral compartments leads inevitably to structural remodeling of the cellular architecture. Recent studies suggested that viral IBs have properties of biomolecular condensates (or liquid organelles), as have previously been shown for other membrane-less cellular compartments like stress granules or P-bodies. Biomolecular condensates are highly dynamic structures formed by liquid-liquid phase separation (LLPS). Key drivers for LLPS in cells are multivalent protein:protein and protein:RNA interactions leading to specialized areas in the cell that recruit molecules with similar properties, while other non-similar molecules are excluded. These typical features of cellular biomolecular condensates are also a common characteristic in the biogenesis of viral inclusion bodies. Viral IBs are predominantly induced by the expression of the viral nucleoprotein (N, NP) and phosphoprotein (P); both are characterized by a special protein architecture containing multiple disordered regions and RNA-binding domains that contribute to different protein functions. P keeps N soluble after expression to allow a concerted binding of N to the viral RNA. This results in the encapsidation of the viral genome by N, while P acts additionally as a cofactor for the viral polymerase, enabling viral transcription and replication. Here, we will review the formation and function of those viral inclusion bodies upon infection with NSVs with respect to their nature as biomolecular condensates.

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Structural characteristics of measles virus entry

Cited by 17 publications

References 53 publications

Study on Structural Characteristics of Composite Smart Grille Based on Principal Component Analysis

Study on Structural Characteristics of Composite Smart Grille Based on Principal Component Analysis

Perspectiva clínico-epidemiológica actual del sarampión en México

New Perspectives on the Biogenesis of Viral Inclusion Bodies in Negative-Sense RNA Virus Infections

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