Structural Characteristics for Superoxide Anion Radical Scavenging and Productive Activities of Green Tea Polyphenols Including Proanthocyanidin Dimers

Sato, Masashi; Toyazaki, Hajime; Yoshioka, Yu; Yokoi, Nobutoshi; Yamasaki, Toru

doi:10.1248/cpb.58.98

Cited by 18 publications

(11 citation statements)

References 38 publications

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“…Scavenging and protective activities of green tea polyphenols [8], preventive effect of green tea catechins on experimental tumor metastasis [9], protective effect of green tea on ethanol-induced lipid peroxidation [10] and tamoxifen-induced liver injury [11] have been reported. Catechins have beneficial effects in prevention of cardiovascular diseases including LDL oxidative susceptibility [12].…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Catechin on d-Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway

et al. 2010

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Objective of this study was to obtain a better understanding of the mechanism responsible for the d-galactosamine (d-GalN) induced hepatotoxicity and to study the effect of catechin against d-GalN induced hepatotoxicity. Catechin 50 and 100 mg/kg b.wt was administered for 1 week by oral route. Liver damage was induced by intra-peritoneal administration of 400 mg/kg b.wt d-galactosamine on the last day of catechin treatment. At the end of treatment all animals were killed and liver enzyme levels were estimated. Dissected hepatic samples were used for histopathology, RNA isolation, expression studies of Bax, Bcl-2 and p53 mRNA levels and mitochondrial membrane potential studies. We found that increases in the liver enzyme activity and decrease in antioxidant enzyme activity by d-GalN were significantly restricted by oral pretreatment with catechin. Disruption of mitochondrial membrane potential, up regulation of p53, Bax and down regulation of Bcl-2 mRNA levels in the liver of d-GalN intoxicated rats were effectively prevented by pretreatment with catechin.

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Section: Introductionmentioning

confidence: 99%

Protective Role of Catechin on d-Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway

et al. 2010

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“…However, using our conditions of analysis, epigallocatechin and gallic acid were shown to have the highest superoxide anion quenching of the polyphenols (Table 4, Fig. 7) but epigallocatechin acted as a superoxide anion generator under the conditions used by Sato et al [21]. Indoxyl sulfate has been shown to be an endogenous antioxidant with superoxide anion scavenging activity generated from activated neutrophils and also it has been shown to eliminate hydroxyl radicals [22].…”

Section: Orac Mr5 Of Pure Phytochemicalsmentioning

confidence: 69%

“…In some cases the scavenging activity was stronger than the production activity. A net scavenging activity was observed for epigallocatechingallate, methyl-gallate, gallocatechin-epigallocatechin and epigallocatechin-epicatechin [21]. However, using our conditions of analysis, epigallocatechin and gallic acid were shown to have the highest superoxide anion quenching of the polyphenols (Table 4, Fig.…”

Section: Orac Mr5 Of Pure Phytochemicalsmentioning

confidence: 72%

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Multi-radical (ORACMR5) antioxidant capacity of selected berries and effects of food processing

Prior¹,

Sintara²,

Chang³

2016

JBR

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Abstract. BACKGROUND:Fruits and berries are known to contain relatively high amounts of antioxidant/bioactive compounds. Several methods have been used for measurement of antioxidant capacity (AC), but not all methods have direct relevance to in vivo antioxidant status. OBJECTIVE: Determine AC in berry/fruit samples, processed berry products, and purified compounds by utilizing 5 different biologically relevant free radical/oxidant sources. METHODS: Samples were assayed for AC capacity using 5 different free radical/oxidant sources: peroxyl radical (ORAC), hydroxyl radical (HORAC), peroxynitrite (NORAC), superoxide anion (SORAC) and singlet oxygen (SOAC)]. Total AC (sum of AC with 5 individual radicals) was expressed as Oxygen Radical Absorption Capacity using Multiple Radicals (ORAC MR5 ). RESULTS: SOAC contributed more than 60% of ORAC MR5 in blackberries, sweet and tart cherries; and no detectable levels of SOAC were found in strawberries, black currants and raspberries. Whole fruit purees of mango, wild blueberry and cherry contained 95, 85 and 67% respectively of total ORAC MR5 from SOAC. However, freeze dried wild blueberry powder from same production season had only 28% as SOAC and 42 and 22% as ORAC and HORAC. Blueberry/Pomegranate and Mango/Pineapple smoothies had 67% and 77% of ORAC MR5 as SOAC. CONCLUSIONS: The antioxidant quenching potential using 5 different radical/oxidant sources of different berries and fruits varied widely and understanding this variation may be helpful in understanding health benefits of different berries and foods.

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“…Enzymatic carboxylation of these compounds would provide an efficient access to more polar derivatives with enhanced water solubility thereby facilitating their formulation and modulating their bioavailability. In addition, the soft electron‐withdrawing effect of the newly introduced carboxylate group should render these products more stable towards autoxidation in analogy to the beneficial effect of the e − ‐withdrawing carbonyl group of green tea polyphenols 16. Furthermore, phenolic acids are expected to impede light‐induced degradation as demonstrated in the case of photolabile substances in food or feed, such as vitamins17a or nucleic acids 17b…”

mentioning

confidence: 99%

Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols

et al. 2017

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In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of o‐benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and polyphenols possessing antioxidant properties. o‐Hydroxycarboxylic acid products were obtained with perfect regioselectivity, in moderate to excellent yields. The applicability of this method was proven by the regioselective bio‐carboxylation of resveratrol on a preparative scale with 95% yield.

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Structural Characteristics for Superoxide Anion Radical Scavenging and Productive Activities of Green Tea Polyphenols Including Proanthocyanidin Dimers

Cited by 18 publications

References 38 publications

Protective Role of Catechin on d-Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway

Protective Role of Catechin on d-Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway

Multi-radical (ORACMR5) antioxidant capacity of selected berries and effects of food processing

Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols

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