Structural characterisation and antioxidant activity evaluation of phenolic compounds from cold-pressed Perilla frutescens var. arguta seed flour

Zhou, Xiaojing; Yan, Linlin; Yin, Peng; Shi, Lingling; Zhang, Jinghua; Liu, Yujun; Ma, Chao

doi:10.1016/j.foodchem.2014.05.062

Cited by 128 publications

(115 citation statements)

References 20 publications

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“…ABTS assay results of the isolated compounds showed similar SC 50 values compared to the previous reports (Chen et al 2007;Begum and Prasad 2012). However, SC 50 value of DPPH assay was lower than in previous studies (Lin et al 2014;Zhou et al 2014), possibly due to the high sensitivity of ESR measurement for DPPH assay. The phytochemicals isolated from rosemary were present in low quantities in the EAF.…”

Section: Radicals Scavenging Activities Of Isolated Compoundssupporting

confidence: 73%

Evaluation of antioxidant potential of ethyl acetate fraction of Rosmarinus officinalis L. and its major components

Hyun

Shrestha

Boo

et al. 2015

J Korean Soc Appl Biol Chem

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The solvent fractions of rosemary methanol extract were obtained by successive extraction with nhexane, chloroform, ethyl acetate, butanol, and water. The ethyl acetate fraction (EAF) contained a remarkable amount of polyphenol and flavonoid as well as high levels of alkyl and 2,2 0 -azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity. The activity guided fractionation and repeated chromatographic separations over silica gel, RP C18, and Sephadex LH-20 led to isolation of six compounds from the EAF. 1 H NMR, 13 C NMR, 2D NMR, MS, and IR spectroscopies determined the compounds to be caffeic acid (1), rosmarinic acid (2), rosmarinic acid methyl ester (3), luteolin (4), apigenin (5), and hispidulin (6), and high-performance liquid chromatography quantification was used to determine concentrations in EAF. Among the six isolated compounds, rosmarinic acid methyl ester showed the highest scavenging activities against di(phenyl)-(2,4,6-trinitrophenyl) iminoazanium, alkyl and ABTS radicals. The EAF mixture, but not individual isolated compounds, shielded dermal fibroblast cells from H 2 O 2 -induced cytotoxicity at concentrations that encompass the SC 50 of alkyl and ABTS radical. Therefore, our findings suggested for the first time that antioxidant capacity of the EAF mixture result in a synergistic effect on the antioxidant action.

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Section: Radicals Scavenging Activities Of Isolated Compoundssupporting

confidence: 73%

Evaluation of antioxidant potential of ethyl acetate fraction of Rosmarinus officinalis L. and its major components

Hyun

Shrestha

Boo

et al. 2015

J Korean Soc Appl Biol Chem

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“…Although, some studies have pointed out the perilla seed meal still contained high‐quality digestible proteins (Longvah & Deosthale, ), polysaccharides, and substantial amounts of phenolic antioxidants (Tang, Sun, & Zhao, ; Zhou et al, ). The most abundant of phenolic compounds in perilla seed meal by‐product are rosmarinic acid, rosmarinic acid‐3‐O‐β‐D‐glycoside, caffeic acid, and caffeic acid‐3‐O‐β‐D‐glycoside (Zhou et al, ). Recently, Zhang et al () have reported that rosmarinic acid‐rich extract from cold‐pressed perilla seed meal showed potential protective effects against oxidative hepatic damage.…”

Section: Introductionmentioning

confidence: 99%

Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal

et al. 2018

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The objective of this study was to investigate the in vitro bioactivities associated with the content of phytochemicals in the extracts from perilla seed meal extract (PSME) compared with dietary seed (PSE). PSE had higher total phenolics and flavonoids content than PSME. However, hydrophilic phytochemical contents in PSME were quantitatively equivalent to PSE. Rosmarinic acid was predominantly found in both extracts. Cell viability and anti‐mutagenicity testing demonstrated that PSE and PSME were biosecured and non‐genotoxic. Both extracts strongly scavenged free radicals and significantly reduced reactive oxygen species (ROS) production. The extracts drastically diminished nitric oxide (NO) production of LPS‐treated RAW 264.7 cells via iNOS mRNA expression. The expression of IL‐6 and COX‐2 were evidently inhibited by these extracts. It could be concluded that PSE and PSME clearly showed in vitro anti‐mutagenicity, antioxidant and anti‐inflammatory capacities. In particular, the by‐product perilla seed meal could be considered as a high nutritive functional food. Practical applications This study suggests that the seed meals, a by‐product from seed oil industry, can be utilized as a valuable dietary source for humans and animals. The high content of polyphenols and their bioactivities can be developed as functional foods, and excipients and fillers in pharmaceuticals and nutraceuticals production. Moreover, recycling of the by‐product seed meals should also reduce environmental and sanitary pollution.

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“…Perilla seed oil is rich in omega-3 fatty acids (53.6%-64%), especially α-linolenic acid (ALA, 18:3, n-3, 52.58%-61.98%) (Zhou et al, 2014). ALA is metabolized to long-chain polyunsaturated fatty acids (LC-PUFA) such as eicosapentaenoic acid (EPA, 20:5, n-3) and docosahexaenoic acid (DHA,22:6,, which are especially important during human brain development (Lee & Song, 2012).…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-assisted aqueous enzymatic extraction of oil from perilla seeds and determination of its physicochemical properties, fatty acid composition and antioxidant activity

Zhang

et al. 2017

Food Sci. Technol

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Response surface methodology (RSM) was used to optimize ultrasound-assisted aqueous enzymatic extraction (UAAEE) conditions for perilla seed oil. Under the optimum conditions-which were a liquid-to-solid ratio of 4.4:1, a hydrolysis time of 2.66 h, a hydrolysis temperature of 50.87 °C and an ultrasound treatment time of 24.74 min-an oil yield of 31.34% was obtained. Comparisons of the physicochemical characteristics of oil obtained using UAAEE with those of oil obtained by solvent extraction (SE oil) and cold pressing extraction (CPE oil) revealed similar refractive indices and saponification values, but UAAEE oil had a higher iodine value and better stability against oxidation, with a low peroxide value. UAAEE oil contained higher levels of beneficial α-linolenic acid and phenolics than SE oil or CPE oil, and it also had superior efficiency in scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.Keywords: perilla seed oil; ultrasound-assisted aqueous enzymatic extraction; physical and chemical characteristics; fatty acid composition; antioxidant activities.Practical Application: Based on its physical and chemical properties, perilla oil obtained using UAAEE would be suitable as high quality edible oil and could also have applications in the cosmetic and pharmaceutical industries.

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Structural characterisation and antioxidant activity evaluation of phenolic compounds from cold-pressed Perilla frutescens var. arguta seed flour

Cited by 128 publications

References 20 publications

Evaluation of antioxidant potential of ethyl acetate fraction of Rosmarinus officinalis L. and its major components

Evaluation of antioxidant potential of ethyl acetate fraction of Rosmarinus officinalis L. and its major components

Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal

Ultrasound-assisted aqueous enzymatic extraction of oil from perilla seeds and determination of its physicochemical properties, fatty acid composition and antioxidant activity

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