Structural changes of ethanolamine plasmalogen during intestinal absorption

Takahashi, Takumi; Kamiyoshihara, Reina; Otoki, Yurika; Ito, Junya; Kato, Shunji; Suzuki, Takuji; Yamashita, Shinji; Eitsuka, Takahiro; Ikeda, Ikuo; Nakagawa, Kiyotaka

doi:10.1039/d0fo01666g

Cited by 12 publications

(16 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lymph duct-cannulation surgery was performed according to a previously described method [ 22 ]. Briefly, a polyvinyl tube (single lumen clear vinyl tube SV-35; 0.5 mm I.D., 0.9 mm O.D.…”

Section: Methodsmentioning

confidence: 99%

Dietary triacylglycerol hydroperoxide is not absorbed, yet it induces the formation of other triacylglycerol hydroperoxides in the gastrointestinal tract

et al. 2022

Self Cite

View full text Add to dashboard Cite

“…Lymph duct-cannulation surgery was performed according to a previously described method [ 22 ]. Briefly, a polyvinyl tube (single lumen clear vinyl tube SV-35; 0.5 mm I.D., 0.9 mm O.D.…”

Section: Methodsmentioning

confidence: 99%

Dietary triacylglycerol hydroperoxide is not absorbed, yet it induces the formation of other triacylglycerol hydroperoxides in the gastrointestinal tract

et al. 2022

Self Cite

View full text Add to dashboard Cite

“…Remarkably, this process has been shown to be more effective for PC[P] than for PE[P] ( Nishimukai et al, 2011 ). Furthermore, the sn -2 position appears to undergo remodeling with a clear preference for enrichment of arachidonic acid during absorption ( Takahashi et al, 2020 ). Following the absorption process, chylomicrons likely serve as vehicles for plasmalogens to enter the circulation via the lymphatic system.…”

Section: Regulation Of Plasmalogen Distribution Across Tissues In Mam...mentioning

confidence: 99%

Regulation of plasmalogen metabolism and traffic in mammals: The fog begins to lift

Dorninger

Werner

Berger

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Due to their unique chemical structure, plasmalogens do not only exhibit distinct biophysical and biochemical features, but require specialized pathways of biosynthesis and metabolization. Recently, major advances have been made in our understanding of these processes, for example by the attribution of the gene encoding the enzyme, which catalyzes the final desaturation step in plasmalogen biosynthesis, or by the identification of cytochrome C as plasmalogenase, which allows for the degradation of plasmalogens. Also, models have been presented that plausibly explain the maintenance of adequate cellular levels of plasmalogens. However, despite the progress, many aspects around the questions of how plasmalogen metabolism is regulated and how plasmalogens are distributed among organs and tissues in more complex organisms like mammals, remain unresolved. Here, we summarize and interpret current evidence on the regulation of the enzymes involved in plasmalogen biosynthesis and degradation as well as the turnover of plasmalogens. Finally, we focus on plasmalogen traffic across the mammalian body – a topic of major importance, when considering plasmalogen replacement therapies in human disorders, where deficiencies in these lipids have been reported. These involve not only inborn errors in plasmalogen metabolism, but also more common diseases including Alzheimer’s disease and neurodevelopmental disorders.

show abstract

“…They also reported a significantly increased plasma level of PlsEtn species if the 1-lyso-PlsEtn and FFA derived from the PlsEtn were gavaged together, and they inferred from their data that PlsEtn was digested to 1-lyso-PlsEtn prior to absorption. In a separate study, Takahashi et al (2020) used lymph canulation in rats and everted sac studies to examine the absorption of PlsEtn species rich in PlsEtn (18:0/22:6) (94%), but also containing PlsEtn (18:0/20:4) and PlsEtn(18:0/18:1). They reported that the main species appearing in the lymph were PlsEtn (18:0/22:6) and PlsEtn(18:0/20:4), in equal quantity, with little evidence of any PlsEtn(18:0/18:1).…”

Section: What Is the Evidence That Dietary Plasmalogens Are Bioavaila...mentioning

confidence: 99%

Enrichment of n‐3 containing ether phospholipids in plasma after 30 days of krill oil compared with fish oil supplementation

Sung

Sinclair

2022

Lipids

View full text Add to dashboard Cite

There are conflicting findings over the bioavailability of long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) from krill oil (KO) compared with fish oil (FO) in short-and long-term studies. The aim of this study was to compare the effects of KO versus FO on the enrichment of molecular species of plasma phospholipids in young women following a 30-day consumption of the n-3 oils. Eleven healthy women aged 18-45 years consumed seven capsules of KO per day (containing a total of 1.27 g n-3 PUFA) or five capsules of FO per day (total of 1.44 g n-3 PUFA) for 30 days in a randomized crossover study, separated by at least a 30-day washout period. Fasting blood samples were collected at day zero (baseline), day 15 and day 30 and analyzed by HPLC-MS/MS for molecular species of phospholipids. Supplementation increased n-3 PUFA in main phospholipids classes in both groups. After 30 days of supplementation, 35 out of 70 molecular species containing eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPAn-3) had a significantly greater concentration in KO group compared with the FO treated group. The majority (89%) of the differentiated molecular species were choline and ethanolamine etherphospholipids. These data reveal that analysis of plasma phospholipids following 30 days of consumption of KO (a marine oil rich in phospholipids, including ether phospholipids) resulted in an enrichment of n-3 PUFA in molecular species of ether-phospholipids compared with FO (a triacylglycerol-rich marine oil).

show abstract

Structural changes of ethanolamine plasmalogen during intestinal absorption

Abstract: A part of ethanolamine plasmalogen (PE-Pls) undergoes structural changes (i.e., arachidonic acid re-esterification and base conversion of PE-Pls into choline plasmalogen (PC-Pls)) during intestinal absorption.

Cited by 12 publications

References 44 publications

Dietary triacylglycerol hydroperoxide is not absorbed, yet it induces the formation of other triacylglycerol hydroperoxides in the gastrointestinal tract

Dietary triacylglycerol hydroperoxide is not absorbed, yet it induces the formation of other triacylglycerol hydroperoxides in the gastrointestinal tract

Regulation of plasmalogen metabolism and traffic in mammals: The fog begins to lift

Enrichment of n‐3 containing ether phospholipids in plasma after 30 days of krill oil compared with fish oil supplementation

Contact Info

Product

Resources

About