Structural Changes of DPPC Bilayers Induced by Gemini Surfactant

Kida, Wojciech; Kozak, Maciej

doi:10.12693/aphyspola.121.893

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…Such phase transition behaviour was characteristic also of other lipid/surfactant mixed systems including those containing anionic or cationic surfactants (such as sodium dodecyl sulfate, dodecyltrimethylammonium bromide [28] or (alcoxymethyl)dodecydimethylammonium chlorides [29,30]), zwitterionic surfactants (e.g., sulfobetaines [31–33]) as well as dicationic surfactants (alkane-α,ω-diyl-bis(dodecyldimethylammonium bromides) [34], 1,1′-(1,6-hexan)bis-3- octyloxymethyl-imidazolium di-chloride [35]).…”

Section: Resultsmentioning

confidence: 99%

Structure and Conformational Dynamics of DMPC/Dicationic Surfactant and DMPC/Dicationic Surfactant/DNA Systems

Pietralik

Krzysztoń

Kida

et al. 2013

IJMS

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Amphiphilic dicationic surfactants, known as gemini surfactants, are currently studied for gene delivery purposes. The gemini surfactant molecule is composed of two hydrophilic “head” groups attached to hydrophobic chains and connected via molecular linker between them. The influence of different concentrations of 1,5-bis (1-imidazolilo-3- decyloxymethyl) pentane chloride (gemini surfactant) on the thermotropic phase behaviour of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) bilayers with and without the presence of DNA was investigated using Fourier transformed infrared (FTIR) and circular dichroism (CD) spectroscopies, small angle scattering of synchrotron radiation and differential scanning calorimetry. With increasing concentration of surfactant in DMPC/DNA systems, a disappearance of pretransition and a decrease in the main phase transition enthalpy and temperature were observed. The increasing intensity of diffraction peaks as a function of surfactant concentration also clearly shows the ability of the surfactant to promote the organisation of lipid bilayers in the multilayer lamellar phase.

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Section: Resultsmentioning

confidence: 99%

Structure and Conformational Dynamics of DMPC/Dicationic Surfactant and DMPC/Dicationic Surfactant/DNA Systems

Pietralik

Krzysztoń

Kida

et al. 2013

IJMS

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show abstract

“…The characterization of gemini bilayer properties is additionally essential for the many proposed biological applications of these surfactants. Gemini surfactants have received considerable interest for applications as antimicrobials, − and as liposome constituents for both drug delivery − and DNA transfection; − in these applications, the surfactant/lipid bilayer interaction is of primary importance. Several mechanistic studies of the interaction between geminis and lipid membranes have been reported.…”

Section: Introductionmentioning

confidence: 99%

Coupling between the Dynamics of Water and Surfactants in Lyotropic Liquid Crystals

McDaniel

Yethiraj

2017

J. Phys. Chem. B

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Bilayers composed of lipid or surfactant molecules are central to biological membranes and lamellar lyotropic liquid crystalline (LLC) phases. Common to these systems are phases that exhibit either ordered or disordered packing of the hydrophobic tails. In this work, we study the impact of surfactant ordering, i.e., disordered L and ordered L LLC phases, on the dynamics of water and sodium ions in the lamellar phases of dicarboxylate gemini surfactants. We study the different phases at identical hydration levels by changing the length of the hydrophobic tails; surfactants with shorter tails form L phases and those with longer tails form L phases. We find that the L phases exhibit lower density and greater compressibility than the L phases, with a hydration-dependent headgroup surface area. These structural differences significantly affect the relative dynamic properties of the phases, primarily the mobility of the surfactant molecules tangential to the bilayer surface, as well as the rates of water and ion diffusion. We find ∼20-50% faster water diffusion in the L phases compared to the L phases, with the differences most pronounced at low hydration. This coupling between water dynamics and surfactant mobility is verified using additional simulations in which the surfactant tails are frozen. Our study indicates that gemini surfactant LLCs provide an important prototypical system for characterizing properties shared with more complex biological lipid membranes.

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Interactions of a cationic surfactant – (benzyloxymethyl) dodecyldimethylammonium chloride with model biomembrane systems

Wypych

Szpotkowski

Jurga

et al. 2013

Colloids and Surfaces B: Biointerfaces

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Structural Changes of DPPC Bilayers Induced by Gemini Surfactant

Cited by 4 publications

References 40 publications

Structure and Conformational Dynamics of DMPC/Dicationic Surfactant and DMPC/Dicationic Surfactant/DNA Systems

Structure and Conformational Dynamics of DMPC/Dicationic Surfactant and DMPC/Dicationic Surfactant/DNA Systems

Coupling between the Dynamics of Water and Surfactants in Lyotropic Liquid Crystals

Interactions of a cationic surfactant – (benzyloxymethyl) dodecyldimethylammonium chloride with model biomembrane systems

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