2002
DOI: 10.1590/s0037-86822002000600010
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Structural changes in the jejunal mucosa of mice infected with Schistosoma mansoni, fed low or high protein diets

Abstract: The effects of high and low-protein diets on the structure of the jejunal mucosa were studied in Schistosoma mansoni infected mice (morphology and histomorphometry). Weaning male albino mice were infected with 80 cercariae, fed with high (20%) or low-protein (5%) diets and compared to uninfected controls under the same conditions. Mice were sacrificed 12 weeks after infection. Animals submitted to a low-protein diet showed lower weight curves, mainly when infected. In the jejunal mucosa, finger-like villi were… Show more

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Cited by 8 publications
(4 citation statements)
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References 16 publications
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“…Concurrent infection with S. mansoni significantly altered the aforementioned anatomical sites mainly during chronic infection, irrespective of diet and the intestinal segment. Our results suggest that morphological alterations begin by week 9 and are aggravated by week 17, consistent with other studies of intestinal pathology (Borgers et al 2000;Couto et al 2002;Siqueira et al 2010). In this study, the damage to the intestinal tissue could be the result of inflammation (Trobojević-Stanković et al 2010) due to the higher number of eggs trapped in the intestine in mice fed a high-fat diet (Neves et al 2007, Alencar et al 2009.…”
Section: Discussionsupporting
confidence: 91%
“…Concurrent infection with S. mansoni significantly altered the aforementioned anatomical sites mainly during chronic infection, irrespective of diet and the intestinal segment. Our results suggest that morphological alterations begin by week 9 and are aggravated by week 17, consistent with other studies of intestinal pathology (Borgers et al 2000;Couto et al 2002;Siqueira et al 2010). In this study, the damage to the intestinal tissue could be the result of inflammation (Trobojević-Stanković et al 2010) due to the higher number of eggs trapped in the intestine in mice fed a high-fat diet (Neves et al 2007, Alencar et al 2009.…”
Section: Discussionsupporting
confidence: 91%
“…Differentiated Paneth cells migrate to the crypt base and they occupy this position for about three weeks before they are replaced. Allocation of cells into these four lineages is known to change in response to disease states, environmental or surgical insult, or position along the small intestine (Dvorak & Dickersin 1980, Ehrmann et al 1990, Kamal et al 2001, Couto et al 2002, Porter et al 2002, Wasserberg et al 2003, Wong, et al 2004). However, the complex set of cues that control this process are unknown.…”
Section: Introductionmentioning
confidence: 99%
“…In this review, while female animals were often used in models testing hyperlipidic diets (Alencar et al 2009(Alencar et al , 2012Da Silva et al 2012), males were used mainly to investigate dietary strategies based on protein manipulation (Couto et al 2002;Ramos et al 2006;Coutinho et al 2007). Female mice have been used since they exhibit a more resistant phenotype against metabolic changes induced by the lipid-rich diet compared with males (Pettersson et al 2012).…”
Section: Discussionmentioning
confidence: 99%