Abstract:The microtubule associated protein (MAP) Tau, primarily expressed in neurons, is known to have a variety of functions such as regulation of microtubule dynamics, modulation of kinesin motor motility and participation in signaling cascades. Research on the microtubule binding behavior of Tau reveals that Tau binds to the microtubule surface in an equilibrium between static and diffusive states. These functional states have been shown to be important in regulating kinesin motility during axonal transport. Howeve… Show more
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