Structural changes in PVDF fibers due to electrospinning and its effect on biological function

Damaraju, Sita M.; Wu, Siliang; Jaffé, Michael; Arinzeh, Treena Livingston

doi:10.1088/1748-6041/8/4/045007

Cited by 158 publications

(131 citation statements)

References 34 publications

(72 reference statements)

Supporting

Mentioning

115

Contrasting

Order By: Relevance

“…Polyvinylidine fluoride (PVDF) (Damaraju, Wu, Jaffe, & Arinzeh, 2013) prepared by electrospinning at different voltages (12 and 25 kV) was compared to tissue culture polystyrene.…”

Section: The Need For Function: Mechano-electrical Stressmentioning

confidence: 99%

Overcoming physical constraints in bone engineering: ‘the importance of being vascularized’

et al. 2015

View full text Add to dashboard Cite

Bone plays several physiological functions and is the second most commonly transplanted tissue after blood. Since the treatment of large bone defects is still unsatisfactory, researchers have endeavoured to obtain scaffolds able to release growth and differentiation factors for mesenchimal stem cells, osteoblasts and endothelial cells in order to obtain faster mineralization and prompt a reliable vascularization.Nowadays, the application of osteoblastic cultures spans from cell physiology and pharmacology to cytocompatibility measurement and osteogenic potential evaluation of novel biomaterials. To overcome the simple traditional monocultures in vitro, co-cultures of osteogenic and vasculogenic precursors were introduced with very interesting results. Increasingly complex culture systems have been developed, where cells are seeded on proper scaffolds and stimulated so as to mimic the physiological conditions more accurately. These bioreactors aim at enabling bone regeneration by incorporating different cells types into bioinspired materials within a surveilled habitat.This review is focused on the most recent developments in the organomimetic cultures of osteoblasts and vascular endothelial cells for bone tissue engineering.

show abstract

“…Polyvinylidine fluoride (PVDF) (Damaraju, Wu, Jaffe, & Arinzeh, 2013) prepared by electrospinning at different voltages (12 and 25 kV) was compared to tissue culture polystyrene.…”

Section: The Need For Function: Mechano-electrical Stressmentioning

confidence: 99%

Overcoming physical constraints in bone engineering: ‘the importance of being vascularized’

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Recently, poly (vinylidene) fluoride (PVDF) and its copolymer poly (vinylidene fluoride-trifluoroethylene) (PVDF-TrFE), both exhibiting piezoelectric characteristics, have been explored as potential scaffold materials for tissue engineering applications. Piezoelectric scaffolds possess the intrinsic property of producing an electrical voltage in response to mechanical deformation without the need for external power sources or electrodes (Damaraju et al, 2013;Lee and Arinzeh, 2012;Martins et al, 2013;Weber et al, 2010a). While the feasibility of PVDF-TrFE scaffolds for bone and neural cell studies have recently been demonstrated, the effect of PVDF-TrFE scaffolds on cardiovascular cells has not yet been explored.…”

Section: Introductionmentioning

confidence: 99%

The effect of PVDF‐TrFE scaffolds on stem cell derived cardiovascular cells

Hitscherich

Gordan

et al. 2016

Biotech & Bioengineering

Self Cite

View full text Add to dashboard Cite

Recently, electrospun polyvinylidene fluoride (PVDF) and polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE) scaffolds have been developed for tissue engineering applications. These materials have piezoelectric activity, wherein they can generate electric charge with minute mechanical deformations. Since the myocardium is an electroactive tissue, the unique feature of a piezoelectric scaffold is attractive for cardiovascular tissue engineering applications. In this study, we examined the cytocompatibility and function of pluripotent stem cell derived cardiovascular cells including mouse embryonic stem cell-derived cardiomyocytes (mES-CM) and endothelial cells (mES-EC) on PVDF-TrFE scaffolds. MES-CM and mES-EC adhered well to PVDF-TrFE and became highly aligned along the fibers. When cultured on scaffolds, mES-CM spontaneously contracted, exhibited well-registered sarcomeres and expressed classic cardiac specific markers such as myosin heavy chain, cardiac troponin T, and connexin43. Moreover, mES-CM cultured on PVDF-TrFE scaffolds responded to exogenous electrical pacing and exhibited intracellular calcium handling behavior similar to that of mES-CM cultured in 2D. Similar to cardiomyocytes, mES-EC also demonstrated high viability and maintained a mature phenotype through uptake of low-density lipoprotein and expression of classic endothelial cell markers including platelet endothelial cell adhesion molecule, endothelial nitric oxide synthase, and the arterial specific marker, Notch-1. This study demonstrates the feasibility of PVDF-TrFE scaffold as a candidate material for developing engineered cardiovascular tissues utilizing stem cell-derived cells. Biotechnol. Bioeng. 2016;113: 1577-1585. © 2015 Wiley Periodicals, Inc.

show abstract

“…2b) were fabricated via electrospinning with the BTO concentrations of 5, 10, 15 and 20 wt%. The FTIR [29][30][31][32] and XRD 29,31,33 studies of the BTO-PVDF mats are presented in Supplementary Note 1.…”

Section: Resultsmentioning

confidence: 99%

Piezoelectric microstructured fibers via drawing of multimaterial preforms

Lü

Skorobogatiy

2018

Energy Harvesting and Storage: Materials, Devices, and Applications VIII

View full text Add to dashboard Cite

We demonstrate planar laminated piezoelectric generators and piezoelectric microstructured fibers based on BaTiO 3 -polyvinylidene and carbon-loaded-polyethylene materials combinations. The laminated piezoelectric generators were assembled by sandwiching the electrospun BaTiO 3 -polyvinylidene mat between two carbon-loaded-polyethylene films. The piezoelectric microstructured fiber was fabricated via drawing of the multilayer fiber preform, and features a swissroll geometry that have ~10 alternating piezoelectric and conductive layers. Both piezoelectric generators have excellent mechanical durability, and could retain their piezoelectric performance after 3 day's cyclic bend-release tests. Compared to the laminated generators, the piezoelectric fibers are advantageous as they could be directly woven into large-area commercial fabrics. Potential applications of the proposed piezoelectric fibers include micro-power-generation and remote sensing in wearable, automotive and aerospace industries.Driven by the ever-growing market of the personal wearable products such as on-garment displays, health-monitoring sensors 1 , virtual-reality devices, smart watches and bracelets, and intelligent glasses, extensive effort has been devoted to the R&D of soft and wearable electronics 2 . The development of wearable and portable electronics has inspired much work 3 in the design and fabrication of flexible fibers which could be used as power sources or sensor components. Among all of these fiber generators or sensors, piezoelectric fibers that operate based on piezoelectric effect 4, 5 are especially attractive, because they could convert mechanical vibrations accessible in our daily life (i.e. walking 6 , air flow 7 and heart beating 3, 8 ) into electrical signals. Another application of piezoelectric generators is related to automotive or aerospace industries 9, 10 . Piezoelectric generators or sensors are implanted on the airplanes and vehicles, for the purpose of structural integrity monitoring 11 , as well as powering the on-board electronic systems such as wireless sensor networks (WSNs) with low-power consumption 12 18 . However, for these fibers, frequent and intensive mechanical movements may potentially damage the fiber structure (e.g. the continuous bending can make the piezoelectric layers cracking, and even peeling off from the fiber core). Thus, the as-fabricated fiber generators typically suffer from poor mechanical reliability, which makes them unsuitable for truly wearable applications. To improve robustness of the fibers, Zhang et al. have coated a thin layer of polydimenthylsiloxane (PDMS) on the roots of ZnO NWs using surface-coating combined with plasma-etching16 . An alternative route for fabrication of the piezoelectric fibers involves the utilization of piezoelectric polymers. In principle, piezoelectric fibers based on piezoelectric polymers usually feature better mechanical robustness and flexibility 19 . Among all of these piezoelectric polymers, poly(vinylidene fluoride) (PVDF) and poly(vinylidene f...

show abstract

Structural changes in PVDF fibers due to electrospinning and its effect on biological function

Cited by 158 publications

References 34 publications

Overcoming physical constraints in bone engineering: ‘the importance of being vascularized’

Overcoming physical constraints in bone engineering: ‘the importance of being vascularized’

The effect of PVDF‐TrFE scaffolds on stem cell derived cardiovascular cells

Piezoelectric microstructured fibers via drawing of multimaterial preforms

Contact Info

Product

Resources

About