Structural Cerebral Network Differences in Prodromal Alzheimer’s Disease and Prodromal Dementia with Lewy Bodies

Ota, Miho; Nemoto, Kiyotaka; Nemoto, Miyuki; Numata, Yuriko; Kitabatake, Ayako; Yamada, Yasunori; Shinkawa, Kaoru; Kobayashi, Masatomo; Arai, Tetsuaki

doi:10.1159/000527443

Cited by 3 publications

(1 citation statement)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Magnetic resonance imaging (MRI) is the gold standard imaging technique for the characterization of brain morphology and visualization of functional processes. Due to the high soft tissue contrast and the possibility of a multi-planar brain evaluation, MRI morphological sequences also enable brain lesions and/or vascular damage to be diagnosed [8].…”

Section: Introductionmentioning

confidence: 99%

Positron Emission Tomography Molecular Imaging of the Major Neurodegenerative Disorders: Overview and Pictorial Essay, from a Nuclear Medicine Center's Perspective

Calabria,

Leporace,

Cimini

et al. 2023

J. Integr. Neurosci.

View full text Add to dashboard Cite

Computed tomography (CT) and magnetic resonance imaging (MRI) provide key structural information on brain pathophysiology. Positron emission tomography (PET) measures metabolism in the living brain; it plays an important role in molecular neuroimaging and is rapidly expanding its field of application to the study of neurodegenerative diseases. Different PET radiopharmaceuticals allow in vivo characterization and quantization of biological processes at the molecular and cellular levels, from which many neurodegenerative diseases develop. In addition, hybrid imaging tools such as PET/CT and PET/MRI support the utility of PET, enabling the anatomical mapping of functional data. In this overview, we describe the most commonly used PET tracers in the diagnostic work-up of patients with Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. We also briefly discuss the pathophysiological processes of tracer uptake in the brain, detailing their specific cellular pathways in clinical cases. This overview is limited to imaging agents already applied in human subjects, with particular emphasis on those tracers used in our department.

show abstract

Section: Introductionmentioning

confidence: 99%

Positron Emission Tomography Molecular Imaging of the Major Neurodegenerative Disorders: Overview and Pictorial Essay, from a Nuclear Medicine Center's Perspective

Calabria,

Leporace,

Cimini

et al. 2023

J. Integr. Neurosci.

View full text Add to dashboard Cite

show abstract

Mild cognitive impairment in dementia with Lewy bodies: an update and outlook

Ka¹

2023

J Neural Transm

View full text Add to dashboard Cite

Characteristics of Alzheimer’s Disease and Mild Cognitive Impairment Influenced by the Time of Onset

Sato,

Ota,

Kitabatake

et al. 2024

Dement Geriatr Cogn Disord Extra

View full text Add to dashboard Cite

Introduction: Although the prevalence of Alzheimer’s disease (AD) is higher in older people compared to younger people, dementia has also been documented in younger adults. Although early-onset dementia and late-onset dementia had been considered a single disease in pathological investigations, many studies revealed differences in cognitive and neuroimaging changes between them. We evaluated differences in cognitive and neuroimaging changes among the following groups: individuals with early-onset AD (EOAD), late-onset AD (LOAD), early-onset mild cognitive impairment (EOMCI), or late-onset MCI (LOMCI), and healthy controls (HCs). Methods: Patients underwent both a 1.5 Tesla magnetic resonance imaging scan and the Mini-Mental State Examination (MMSE). Differences in regional gray matter volumes and MMSE subscales were investigated among the five diagnostic groups. Results: Compared to the EOAD group, the LOAD group had significantly higher scores on orientation in place. Compared to the LOMCI patients, the EOMCI patients achieved significantly higher recall scores. The LOAD and LOMC groups showed significant volume reductions in bilateral medial temporal regions compared to the HCs. The EOAD and EOMCI groups did not show significant atrophy of the medial temporal region compared to the HC group. Conclusions: The hippocampal volume and memory were preserved in the patients with EOMCI or EOAD compared to those with LOMCI or LOAD. These findings may indicate that the distinct and differing patterns of neuropsychological changes between EOAD and LOAD are also common in MCI, which is intermediate between normal cognition and AD.

show abstract

Structural Cerebral Network Differences in Prodromal Alzheimer’s Disease and Prodromal Dementia with Lewy Bodies

Cited by 3 publications

References 43 publications

Positron Emission Tomography Molecular Imaging of the Major Neurodegenerative Disorders: Overview and Pictorial Essay, from a Nuclear Medicine Center's Perspective

Positron Emission Tomography Molecular Imaging of the Major Neurodegenerative Disorders: Overview and Pictorial Essay, from a Nuclear Medicine Center's Perspective

Mild cognitive impairment in dementia with Lewy bodies: an update and outlook

Characteristics of Alzheimer’s Disease and Mild Cognitive Impairment Influenced by the Time of Onset

Contact Info

Product

Resources

About