Structural Brain Connectome and Cognitive Impairment in Parkinson                    Disease

Galantucci, Sebastiano; Agosta, Federica; Stefanova, Elka; Basaia, Silvia; Heuvel, Martijn P. van den; Stojković, Tanja; Canu, Elisa; Stanković, Iva; Špica, Vladana; Copetti, Massimiliano; Gagliardi, Delia; Kostić, Vladimir; Filippi, Massimo

doi:10.1148/radiol.2016160274

Cited by 77 publications

(85 citation statements)

References 27 publications

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“…Conversely, WM functional networks become more optimal in PD patients. This was different from previous findings concerning WM structure (Galantucci et al, 2017) and GM function (Gottlich et al, 2013;Kim et al, 2017) in PD patients, and suggests a functionalstructural decoupling at the network level.…”

Section: Discussioncontrasting

confidence: 99%

“…For instance, while some studies reported no significant FA abnormality in PD patients (Hattori et al, ; Worker et al, ), others found widespread FA changes (Li et al, ). Using a large sample‐size (170 patients), Galantucci and colleagues found significant FA decreases in the corpus collosum and associative frontoparietal tracts in PD patients relative to controls (Galantucci et al, ). Consistent with this, we found significantly decreased FA in the left cingulum connecting the frontal and parietal cortices.…”

Section: Discussionmentioning

confidence: 99%

“…However, the TBSS findings in PD patients have differed between studies. While some studies have found normal fractional anisotropy (FA) in PD patients (Hattori et al, ; Worker et al, ), others reported limited (Galantucci et al, ) or widespread (Li, Ren, Cao, & Huang, ) abnormalities in brain WM. When using graph‐theoretical analysis, structural topological properties of regions (i.e., small‐worldness and efficiency) can be estimated by the diffusion features of fiber tracts (Gong et al, ; Hagmann et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…It has been demonstrated that the brain structural network is a small‐world network with many local connections, and a few long‐distance connections, an arrangement which is optimal for synchronizing neuronal activity between different brain regions (Bullmore & Sporns, ; Ji et al, ). This small‐worldness has been shown to be disrupted in PD patients if they also present with mild cognitive impairment (Galantucci et al, ). All these advances have improved our understanding of the structural changes that underlie clinical symptoms of PD (Hall et al, ), and may also help in classifying healthy controls or patients with other neurodegeneration diseases (Cochrane & Ebmeier, ).…”

Section: Introductionmentioning

confidence: 99%

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Regional and network properties of white matter function in Parkinson's disease

Cuiping

Liu

et al. 2018

Human Brain Mapping

104

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Parkinson's disease (PD) is a neurodegenerative disorder with dysfunction in cortices as well as white matter (WM) tracts. While the changes to WM structure have been extensively investigated in PD, the nature of the functional changes to WM remains unknown. In this study, the regional activity and functional connectivity of WM were compared between PD patients (n = 57) and matched healthy controls (n = 52), based on multimodel magnetic resonance imaging data sets. By tract‐based spatial statistical analyses of regional activity, patients showed decreased structural‐functional coupling in the left corticospinal tract compared to controls. This tract also displayed abnormally increased functional connectivity within the left post‐central gyrus and left putamen in PD patients. At the network level, the WM functional network showed small‐worldness in both controls and PD patients, yet it was abnormally increased in the latter group. Based on the features of the WM functional connectome, previously un‐evaluated individuals could be classified with fair accuracy (73%) and area under the curve of the receiver operating characteristics (75%). These neuroimaging findings provide direct evidence for WM functional changes in PD, which is crucial to understand the functional role of fiber tracts in the pathology of neural circuits.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regional and network properties of white matter function in Parkinson's disease

Cuiping

Liu

et al. 2018

Human Brain Mapping

104

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“…To minimize the presence of spurious fibers, an edge was set to zero if the NOS was fewer than three as a first thresholding step (Collin, Kahn, de Reus, Cahn, & van den Heuvel, ; Galantucci et al, ). In addition, a group consensus threshold of 60% was employed to provide a good balance between eliminating false positives and false negatives (de Reus & van den Heuvel, ).…”

Section: Methodsmentioning

confidence: 99%

Impaired rich club and increased local connectivity in children with traumatic brain injury: Local support for the rich?

Verhelst

Linden

Pauw

et al. 2018

Human Brain Mapping

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Recent evidence has shown the presence of a "rich club" in the brain, which constitutes a core network of highly interconnected and spatially distributed brain regions, important for high-order cognitive processes. This study aimed to map the rich club organization in 17 young patients with moderate to severe TBI (15.71 ± 1.75 years) in the chronic stage of recovery and 17 age- and gender-matched controls. Probabilistic tractography was performed on diffusion weighted imaging data to construct the edges of the structural connectomes using number of streamlines as edge weight. In addition, the whole-brain network was divided into a rich club network, a local network and a feeder network connecting the latter two. Functional outcome was measured with a parent questionnaire for executive functioning. Our results revealed a significantly decreased rich club organization (p values < .05) and impaired executive functioning (p < .001) in young patients with TBI compared with controls. Specifically, we observed reduced density values in all three subnetworks (p values < .005) and a reduced mean strength in the rich club network (p = .013) together with an increased mean strength in the local network (p = .002) in patients with TBI. This study provides new insights into the nature of TBI-induced brain network alterations and supports the hypothesis that the local subnetwork tries to compensate for the biologically costly subnetwork of rich club nodes after TBI.

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Structural connectivity networks in Alzheimer’s disease and Lewy body disease

et al. 2021

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Objective We evaluated disruption of the white matter (WM) network related with Alzheimer's disease (AD) and Lewy body disease (LBD), which includes Parkinson's disease and dementia with Lewy bodies. Methods We consecutively recruited 37 controls and 77 patients with AD‐related cognitive impairment (ADCI) and/or LBD‐related cognitive impairment (LBCI). Diagnoses of ADCI and LBCI were supported by amyloid PET and dopamine transporter PET, respectively. There were 22 patients with ADCI, 19 patients with LBCI, and 36 patients with mixed ADCI/LBCI. We investigated the relationship between ADCI, LBCI, graph theory‐based network measures on diffusion tensor images, and cognitive dysfunction using general linear models after controlling for age, sex, education, deep WM hyperintensities (WMH), periventricular WMH, and intracranial volume. Results LBCI, especially mixed with ADCI, was associated with increased normalized path length and decreased normalized global efficiency. LBCI was related to the decreased nodal degree of left caudate, which was further associated with broad cognitive dysfunction. Decreased left caudate nodal degree was associated with decreased fractional anisotropy (FA) in the brain regions vulnerable to LBD. Compared with the control group, the LBCI group had an increased betweenness centrality in the occipital nodes, which was associated with decreased FA in the WM adjacent to the striatum and visuospatial dysfunction. Conclusion Concomitant ADCI and LBCI are associated with the accentuation of LBCI‐related WM network disruption centered in the left caudate nucleus. The increase of occipital betweenness centrality could be a characteristic biologic change associated with visuospatial dysfunction in LBCI.

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Structural Brain Connectome and Cognitive Impairment in Parkinson Disease

Cited by 77 publications

References 27 publications

Regional and network properties of white matter function in Parkinson's disease

Regional and network properties of white matter function in Parkinson's disease

Impaired rich club and increased local connectivity in children with traumatic brain injury: Local support for the rich?

Structural connectivity networks in Alzheimer’s disease and Lewy body disease

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