Structural brain changes following peripheral vestibulo-cochlear lesion may indicate multisensory compensation

Helmchen, Christoph; Klinkenstein, J.; Krüger, Alexandra; Gliemroth, Jan; Mohr, Christian; Sander, T.

doi:10.1136/jnnp.2010.204925

Cited by 46 publications

(41 citation statements)

References 42 publications

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“…Helmchen et al (11) investigated morphometric changes in the vestibular and auditory cortices following vestibulocochlear lesion using VBM. Their study suggested structural cortical plasticity in multisensory vestibular areas of patients with unilateral peripheral vestibulocochlear lesion after surgical removal of acoustic neuroma.…”

Section: Discussionmentioning

confidence: 99%

“…Their study suggested structural cortical plasticity in multisensory vestibular areas of patients with unilateral peripheral vestibulocochlear lesion after surgical removal of acoustic neuroma. Structural brain changes may reflect central mechanisms of vestibular compensation (11). Decreased gray matter volume (GMV) in ipsilesional vestibular cortex and increased GMV in contralesional vestibular cortex might contribute to vestibular compensation (11).…”

Section: Discussionmentioning

confidence: 99%

“…Structural brain changes may reflect central mechanisms of vestibular compensation (11). Decreased gray matter volume (GMV) in ipsilesional vestibular cortex and increased GMV in contralesional vestibular cortex might contribute to vestibular compensation (11).…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have been performed on tumor using MRI (8)(9)(10), also few studies have argued for probably effects of vestibular disorders on auditory cortex using a variety of methods such as voxel-based morphometry (VBM), positron emission tomography (PET), and neuropsychiatric tests (11,12). However, to our knowledge, there is no study searching for the effect of acoustic neuroma on auditory cortex in the vicinity of the HG using MRS. We investigated to examine whether there are changes in metabolites of HG in patients with acoustic neuroma and investigate which side being more affected on single-voxel proton MRS.…”

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confidence: 98%

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Magnetic Resonance Spectroscopy Features of Heschl's Gyri in Patients with Unilateral Acoustic Neuroma

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 98%

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Magnetic Resonance Spectroscopy Features of Heschl's Gyri in Patients with Unilateral Acoustic Neuroma

et al. 2014

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“…По данным многочис-ленных исследований, чем раньше начата вестибулярная реабилитация, тем быстрее происходит восстановле-ние [27].…”

Section: неврология нейропсихиатрия психосоматика 2018;10(1):96-101unclassified

Vestibular vertigo treatment in a polymorbid patient

Kosivtsova

Yavorskaya

Fateeva

2018

RJTAO

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О б щ и е в о п р о с ы т е р а п и и Лечение пациентов с головокружением вызывает трудно-сти у многих неврологов. В большинстве случаев головокруже-ние имеет благоприятное течение, и симптомы самостоятельно регрессируют. Если головокружение не проходит и не уточнена его причина, пациентов направляют в специализированные центры. К сожалению, в нашей стране отсутствуют специали-зированные центры для пациентов с головокружением, в кото-рых проводится полное отоневрологическое обследование, ус-танавливается правильный диагноз и назначается дифферен-цированная современная терапия, которая включает фармако-логическую терапию и вестибулярную реабилитацию.Вестибулярное головокружение у большинства паци-ентов вызвано патологией периферического вестибулярного аппарата (например, лабиринта или вестибулярного нерва), реже -повреждением центральных структур (ствола голов-ного мозга или мозжечка) [

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Hippocampal gray matter volume in bilateral vestibular failure

Göttlich

Jandl

Sprenger

et al. 2016

Human Brain Mapping

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Bilateral vestibular failure (BVF) is a severe chronic disorder of the labyrinth or the eighth cranial nerve characterized by unsteadiness of gait and disabling oscillopsia during head movements. According to animal data, vestibular input to the hippocampus is proposed to contribute to spatial memory and spatial navigation. Except for one seminal study showing the association of impaired spatial navigation and hippocampal atrophy, patient data in BVF are lacking. Therefore, we performed a voxel-wise comparison of the hippocampal gray matter volume (GMV) in a clinically representative sample of 27 patients with incomplete BVF and 29 age- and gender-matched healthy controls to test the hypothesis of hippocampal atrophy in BVF. Although the two groups did not generally differ in their hippocampal GMV, a reduction of GMV in the bilateral hippocampal CA3 region was significantly correlated with increased vestibulopathy-related clinical impairment. We propose that GMV reduction in the hippocampus of BVF patients is related to the severity of vestibular-induced disability which is in line with combined hippocampal atrophy and disorders of spatial navigation in complete vestibular deafferentation due to bilateral nerve section. Clinically, however, the most frequent etiologies of BVF cause incomplete lesions. Accordingly, hippocampus atrophy and deficits in spatial navigation occur possibly less frequently than previously suspected. Hum Brain Mapp 37:1998-2006, 2016. © 2016 Wiley Periodicals, Inc.

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Structural brain changes following peripheral vestibulo-cochlear lesion may indicate multisensory compensation

Cited by 46 publications

References 42 publications

Magnetic Resonance Spectroscopy Features of Heschl's Gyri in Patients with Unilateral Acoustic Neuroma

Magnetic Resonance Spectroscopy Features of Heschl's Gyri in Patients with Unilateral Acoustic Neuroma

Vestibular vertigo treatment in a polymorbid patient

Hippocampal gray matter volume in bilateral vestibular failure

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