Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus
Ignacio Fernández,
Nell Saunders,
Stéphane Duquerroy
et al.
Abstract:The human seasonal coronavirus HKU1-CoV, which causes common colds worldwide, relies on the sequential binding to a cell-surface glycan and to TMPRSS2 for entry into target cells. TMPRSS2 is a cell surface protease synthesized as a zymogen that undergoes autolytic activation to process its substrates. Several respiratory viruses - in particular coronaviruses - use TMPRSS2 for proteolytic priming of their surface spike protein to drive membrane fusion upon receptor binding. We describe the crystal structure of … Show more
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