Structural Basis of the Dehydratase Module (hDH) of Human Fatty Acid Synthase
Chang Cai,
Yuzhou Huang,
Lin Zhang
et al.
Abstract:The human fatty acid synthase (hFASN) produces fatty acids for cellar membrane construction, energy storage, biomolecule modifications and signal transduction. Abnormal expression and functions of hFASN highly associate with numerous human diseases such as obesity, diabetes, and cancers, and thereby it has been considered as a valuable potential drug target. So far, the structural and catalytic mechanisms of most of the hFASN enzymatic modules have been extensively studied, except the key dehydratase module (h… Show more
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