“…Higher‐order complexes, that is, oligomers in which the number of monomers in a complex is broadly distributed and can be large, have important functions in signal transduction and cell fate decisions (Credle et al , 2005; Korennykh et al , 2009; Yin et al , 2009; Li et al , 2012a; Banjade & Rosen, 2014; Lu et al , 2014; Xu et al , 2014). The inherent size heterogeneity of such higher‐order assemblies generates challenges for their structural and mechanistic characterization, but recent progress has provided insight into their ability to mediate signal amplification, filter noise, and regulate signaling in time and space (Li et al , 2012b; Wu, 2013).…”