Structural basis for the hepatoprotective effects of antihypertensive 1,4-dihydropyridine drugs

Wei, Yijuan; Lu, Yi; Zhu, Yujia; Zheng, Weili; Guo, Feng; Yao, Benqiang; Xu, Shuping; Wang, Yumeng; Jin, Lihua; Li, Yong

doi:10.1016/j.bbagen.2018.07.022

Cited by 9 publications

(3 citation statements)

References 42 publications

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“…Neovascularization induced by TNF-α was found to be inhibited by nifidepine and its analogues [ 117 ]. The antioxidant features, GABA receptor inhibition, and analgesic properties [ 118 ]; hepatoprotective [ 119 , 120 ]; antifungal [ 121 , 122 ]; antiplatelet [ 123 , 124 ]; and bronchodilatory activities [ 125 ] are other features of DHPMs depending on their decorated functionalities and substituents.…”

Section: Other Therapeutic Accomplishments Of Dihydroyrimidinesmentioning

confidence: 99%

Synthesis of Dihydropyrimidines: Isosteres of Nifedipine and Evaluation of Their Calcium Channel Blocking Efficiency

et al. 2023

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Hypertension and cardiovascular diseases related to it remain the leading medical challenges globally. Several drugs have been synthesized and commercialized to manage hypertension. Some of these drugs have a dihydropyrimidine skeleton structure, act as efficient calcium channel blockers, and affect the calcium ions’ intake in vascular smooth muscle, hence managing hypertension. The synthesis of such moieties is crucial, and documenting their structure–activity relationship, their evolved and advanced synthetic procedures, and future opportunities in this area is currently a priority. Tremendous efforts have been made after the discovery of the Biginelli condensation reaction in the synthesis of dihydropyrimidines. From the specific selection of Biginelli adducts to the variation in the formed intermediates to achieve target compounds containing heterocylic rings, aldehydes, a variety of ketones, halogens, and many other desired functionalities, extensive studies have been carried out. Several substitutions at the C3, C4, and C5 positions of dihydropyrimidines have been explored, aiming to produce feasible derivatives with acceptable yields as well as antihypertensive activity. The current review aims to cover this requirement in detail.

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Section: Other Therapeutic Accomplishments Of Dihydroyrimidinesmentioning

confidence: 99%

Synthesis of Dihydropyrimidines: Isosteres of Nifedipine and Evaluation of Their Calcium Channel Blocking Efficiency

et al. 2023

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“…The FXR agonists include steroid compounds such as BAs and their derivatives, 17β-(4-hydroxybenzoyl) androsta-3,5-diene-3-carboxylic acid (MFA-1), and non-steroid ligands including isoxazole GW4064 and derivatives (Feng et al, 2009), benzopyran fexaramine and derivatives (Downes et al, 2003), azapyrene WAY-362450 and derivatives (Flatt et al, 2009), benzimidazolyl amide compounds (Richter et al, 2011), etc. Additionally, some drugs on the market are identified as novel FXR modulators and have been repurposed to show promising potential in treating BA-mediated diseases by targeting FXR, such as the anti-parasitic drug ivermectin and its analogues (Jin et al, 2013(Jin et al, , 2015, and anti-hypertension drugs 1,4-dihydropyridines (DHPs) (Wei et al, 2018). There are also many natural products identified as FXR ligands.…”

Section: Drug Discovery By Targeting Fxrmentioning

confidence: 99%

Bile-ology: from bench to bedside

Jin

Fang

Fan

et al. 2019

J. Zhejiang Univ. Sci. B

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Bile acids (BAs) are originally known as detergents essential for the digestion and absorption of lipids. In recent years, extensive research has unveiled new functions of BAs as gut hormones that modulate physiological and pathological processes, including glucose and lipid metabolism, energy expenditure, inflammation, tumorigenesis, cardiovascular disease, and even the central nervous system in addition to cholesterol homeostasis, enterohepatic protection and liver regeneration. BAs are closely linked with gut microbiota which might explain some of their crucial roles in organs. The signaling actions of BAs can also be mediated through specific nuclear receptors and membranebound G protein-coupled receptors. Several pharmacological agents or bariatric surgeries have demonstrated efficacious therapeutic effects on metabolic diseases through targeting BA signaling. In this mini-review, we summarize recent advances in bile-ology, focusing on its translational studies.

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“…Dihydropyridines are well‐known effective calcium channel blocker drugs for the treatment of hypertension and cardiovascular diseases. [ 7 ] Combining the core structures of spirooxindole and dihydropyridine in a new molecular hybrid exhibits synergic properties in programmed drug design and further evaluation. The use of combinatorial methods by multi‐component reaction for the high‐throughput synthesis of this drug‐like scaffold will be a powerful tool to help accelerate drug discovery.…”

Section: Introductionmentioning

confidence: 99%

Nickel supported on magnetic biochar as a highly efficient and recyclable heterogeneous catalyst for the one‐pot synthesis of spirooxindole‐dihydropyridines

Dong

Wang

Zhang

et al. 2022

Applied Organom Chemis

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Magnetic materials show promising applications in heterogeneous catalysis because of their ease of separation and good reusability. The present work reports the design, synthesis, and characterization of a novel magnetic biochar supported nickel catalyst. Fourier infrared spectroscopy (FT‐IR), powder X‐ray diffraction technology (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), and vibrating sample magnetometer (VSM) techniques were used for analyzing the prepared catalyst. The prepared catalyst exhibited excellent catalytic activity for synthesis of spirooxindole‐dihydropyridines derivatives by a one‐pot three‐component reaction of isatin, barbituric acid, and 6‐amino uracil or 1H‐pyrazol‐5‐amine. This new methodology demonstrated some important features, including high yields, lower loading of the catalyst, easy work‐up, and recyclability of the catalyst for a minimum of six times without an obvious decay of catalytic performance.

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Structural basis for the hepatoprotective effects of antihypertensive 1,4-dihydropyridine drugs

Cited by 9 publications

References 42 publications

Synthesis of Dihydropyrimidines: Isosteres of Nifedipine and Evaluation of Their Calcium Channel Blocking Efficiency

Synthesis of Dihydropyrimidines: Isosteres of Nifedipine and Evaluation of Their Calcium Channel Blocking Efficiency

Bile-ology: from bench to bedside

Nickel supported on magnetic biochar as a highly efficient and recyclable heterogeneous catalyst for the one‐pot synthesis of spirooxindole‐dihydropyridines

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