“…B*2705 and B*1403 show only 3%-5% peptide sharing 14 . Interestingly, a single peptide, IRAAPPPLF, derived from cathepsin A signal sequence residues 2-10, binds B*2705, B*2709, B*1402, and B*1403, and a crystallographic study of the first 3 alleles (B*1403 crystals could not be obtained) showed that all bind this peptide with the same conformation 15 . This peptide binding evidently might account for the very limited alloreactive cytotoxic T lymphocytes (CTL) cross-reactivity observed among B*2705, B*1402, and B*1403 14 .…”