Structural and topological design of conformal bilayered scaffolds for bone tissue engineering

Vaiani, Lorenzo; Uva, Antonio E.; Boccaccio, Antonio

doi:10.1016/j.tws.2023.111209

Cited by 5 publications

(4 citation statements)

References 88 publications

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“…An advantage of non-parametric design is that the scaffolds are more accessible to manufacture due to their simple geometries, as they do not require specialised algorithms to generate. Parametric designs, on the other hand, leverage more complex algorithms to create complicated structures, such as Triply Periodic Minimal Surfaces (TPMS) [51] and Voronoi structures [52,53]. Modern additive manufacturing technologies (AM) are capable of producing such complex designs [54,55].…”

Section: Types Of Designsmentioning

confidence: 99%

Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

N. Musthafa,

Walker,

Domagala

2024

Computation

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Three-dimensional porous scaffolds are substitutes for traditional bone grafts in bone tissue engineering (BTE) applications to restore and treat bone injuries and defects. The use of computational modelling is gaining momentum to predict the parameters involved in tissue healing and cell seeding procedures in perfusion bioreactors to reach the final goal of optimal bone tissue growth. Computational modelling based on finite element method (FEM) and computational fluid dynamics (CFD) are two standard methodologies utilised to investigate the equivalent mechanical properties of tissue scaffolds, as well as the flow characteristics inside the scaffolds, respectively. The success of a computational modelling simulation hinges on the selection of a relevant mathematical model with proper initial and boundary conditions. This review paper aims to provide insights to researchers regarding the selection of appropriate finite element (FE) models for different materials and CFD models for different flow regimes inside perfusion bioreactors. Thus, these FEM/CFD computational models may help to create efficient designs of scaffolds by predicting their structural properties and their haemodynamic responses prior to in vitro and in vivo tissue engineering (TE) applications.

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Section: Types Of Designsmentioning

confidence: 99%

Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

N. Musthafa,

Walker,

Domagala

2024

Computation

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“…These scaffolds improve osseointegration and tissue 2 of 22 ingrowth in addition to mimicking the natural porosity of bone, which usually varies from 60% to 90% [12][13][14][15][16][17]. Because of this, Voronoi lattices are necessary for making biomimetic implants because they offer a customized method that is better at copying the complex anatomical and functional details of human bone than other types of lattices [18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Advancing 3D Dental Implant Finite Element Analysis: Incorporating Biomimetic Trabecular Bone with Varied Pore Sizes in Voronoi Lattices

Alemayehu,

Todoh,

Huang

2024

JFB

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The human mandible’s cancellous bone, which is characterized by its unique porosity and directional sensitivity to external forces, is crucial for sustaining biting stress. Traditional computer- aided design (CAD) models fail to fully represent the bone’s anisotropic structure and thus depend on simple isotropic assumptions. For our research, we use the latest versions of nTOP 4.17.3 and Creo Parametric 8.0 software to make biomimetic Voronoi lattice models that accurately reflect the complex geometry and mechanical properties of trabecular bone. The porosity of human cancellous bone is accurately modeled in this work using biomimetic Voronoi lattice models. The porosities range from 70% to 95%, which can be achieved by changing the pore sizes to 1.0 mm, 1.5 mm, 2.0 mm, and 2.5 mm. Finite element analysis (FEA) was used to examine the displacements, stresses, and strains acting on dental implants with a buttress thread, abutment, retaining screw, and biting load surface. The results show that the Voronoi model accurately depicts the complex anatomy of the trabecular bone in the human jaw, compared to standard solid block models. The ideal pore size for biomimetic Voronoi lattice trabecular bone models is 2 mm, taking in to account both the von Mises stress distribution over the dental implant, screw retention, cortical bone, cancellous bone, and micromotions. This pore size displayed balanced performance by successfully matching natural bone’s mechanical characteristics. Advanced FEA improves the biomechanical understanding of how bones and implants interact by creating more accurate models of biological problems and dynamic loading situations. This makes biomechanical engineering better.

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“…The cell adhesion process is the main interest of the many researchers who try to design and optimize the surface of biodevices, such as scaffolds for bone tissue engineering. The analysis of the current state of the art indicates that extensive research was conducted to determine the optimal scaffold architecture [37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52]; however, rather few studies focused on the identification of the optimal surface micro-geometry favoring the most extended adhesion of mesenchymal stem cells (MSCs) to the scaffold walls and their subsequent differentiation in the osteoblastic sense [53].…”

Section: Introduction 1theoretical Background (Principles) Of Cell Ad...mentioning

confidence: 99%

Finite Element Modeling of Cells Adhering to a Substrate: An Overview

Santoro,

Vaiani,

Boccaccio

et al. 2024

Applied Sciences

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In tissue formation and regeneration processes, cells often move collectively, maintaining connections through intercellular adhesions. However, the specific roles of cell–substrate and cell-to-cell mechanical interactions in the regulation of collective cell migration are not yet fully understood. Finite element modeling (FEM) may be a way to assess more deeply the biological, mechanical, and chemical phenomena behind cell adhesion. FEM is a powerful tool widely used to simulate phenomena described by systems of partial differential equations. For example, FEM provides information on the stress/strain state of a cell adhering to a substrate, as well as on its mechanobiological behavior. This review paper, after briefly describing basic principles of cell adhesion, surveys the most important studies that have utilized FEM to investigate the structural response of a cell adhering to a substrate and how the forces acting on the cell–substrate adhesive structures affect the global cell mechanical behavior.

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Structural and topological design of conformal bilayered scaffolds for bone tissue engineering

Cited by 5 publications

References 88 publications

Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

Advancing 3D Dental Implant Finite Element Analysis: Incorporating Biomimetic Trabecular Bone with Varied Pore Sizes in Voronoi Lattices

Finite Element Modeling of Cells Adhering to a Substrate: An Overview

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