Structural and spectroscopic characterizations in Pb2+-doped calcium hydroxyapatites

Mehnaoui, M.; Panczer, G.; Ternane, Riadh; Trabelsi‐Ayedi, M.; Boulon, G.

doi:10.1016/j.optmat.2007.11.006

Cited by 15 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Copper‐containing HA has also been studied for the design of drug carriers 9. On the other hand, the incorporation of heavy metals, such as Pb 2+ , onto HA and bone may be very undesirable due to their possible toxic effects, involvement on bone diseases, and osteoporetic processes 10…”

Section: Introductionmentioning

confidence: 99%

Understanding the impact of divalent cation substitution on hydroxyapatite: An in vitro multiparametric study on biocompatibility

Lima

Alves

Soriano

et al. 2011

J Biomedical Materials Res

View full text Add to dashboard Cite

Hydroxyapatite (HA), a stable and biocompatible material for bone tissue therapy, may present a variable stoichiometry and accept a large number of cationic substitutions. Such substitutions may modify the chemical activity of HA surface, with possible impact on biocompatibility. In this work, we assessed the effects of calcium substitution with diverse divalent cations (Pb(2+), Sr(2+), Co(2+), Zn(2+), Fe(2+), Cu(2+), or Mg(2+)) on the biological behavior of HA. Physicochemical analyses revealed that apatite characteristics related to crystallinity and calcium dissolution/uptake rates are very sensitive to the nature of cationic substitution. Cytocompatibility was evaluated by mitochondrial activity, membrane integrity, cell density, proapoptotic potential, and adhesion tests. With the exception of Zn-HA, all the substituted HAs induced some level of apoptosis. The highest apoptosis levels were observed for Mg-HA and Co-HA. Cu-HA was the only material to impair simultaneously mitochondrial activity, membrane integrity, and cell density. The highest relative cell densities after exposure to the modified HAs were observed for Mg-HA and Zn-HA, while Co-HA significantly improved cell adhesion onto HA surface. These results show that changes on surface dissolution caused by cationic substitution, as well as the increase of metal species released to biological media, were the main responsible factors related to alterations on HA biocompatibility.

show abstract

Section: Introductionmentioning

confidence: 99%

Understanding the impact of divalent cation substitution on hydroxyapatite: An in vitro multiparametric study on biocompatibility

Lima

Alves

Soriano

et al. 2011

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…Among such materials, it could be highlight the employment of calcium phosphates, especially hydroxyapatite (HA), which presents several chemical, biological and crystallographic similarities with the mineral phase of human bone, therefore being recognized as very biocompatible, and presenting well known osteoconductive properties 2,3 . Another important characteristic of HA is the possibility of incorporation of other components, such as metallic ions, on its structure [4][5][6] , thus promoting alterations on important physicochemical properties with impact on the biological response to this biomaterial. Also, this substitution may include bioactive elements or ions, which could also modulate important events related to bone regeneration, as they are released from HA onto biological media 7 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the in vivo biocompatibility of hydroxyapatite granules incorporated with zinc ions

et al. 2010

View full text Add to dashboard Cite

“…From x 1 (10%), we observed a high quenching of the blue emission (figure 4). According to Andres-Verges et al [23] and to our recent results on the luminescence of divalent lead in the calcium hydroxyapatites [24], the blue intense emission is ascribed to Pb 2+ ions in the Ca II site whereas the weak UV emission is related to Pb 2+ ions in the Ca I site. As the temperature decreases the ultraviolet band becomes more intense us is usual in such compounds and shifts towards the higher wavelength as the deconvolution of the spectra shows it.…”

Section: Ir Investigationmentioning

confidence: 66%

Structural and luminescent properties of new Pb²⁺-doped calcium chlorapatites Ca_10−xPb_x(PO₄)₆ Cl₂ (0≤x≤10)

Mehnaoui

Ternane²,

Panczer

et al. 2008

J. Phys.: Condens. Matter

View full text Add to dashboard Cite

Excitation and emission spectra of Pb(2+) ions in Ca(10-x)Pb(x)(PO(4))(6)Cl(2) (0≤x≤10) compounds are investigated for various activator concentrations at different temperatures. A calcium-lead chlorapatite system shows a common apatitic structure and occurs as a continuous solid solution. An attempt to identify the pure electronic transitions between the ground and the excited levels of Pb(2+) is made. As a consequence of the two different sites in the apatite, two emission bands due to the [Formula: see text] (at room temperature) and [Formula: see text] (at low temperature) transitions of the Pb(2+) ions are observed. Decay times of Pb(2+) emission have been measured. Experimental data point out thermalization between (3)P(1) and (3)P(0) levels, for example, at very low temperature, the forbidden transition [Formula: see text] is the most intense. The overlap between the emission band of one site and the excitation band of the other site corresponds to an energy transfer phenomenon. Correlations between the luminescence results and the structural data are discussed.

show abstract

Structural and spectroscopic characterizations in Pb2+-doped calcium hydroxyapatites

Cited by 15 publications

References 16 publications

Understanding the impact of divalent cation substitution on hydroxyapatite: An in vitro multiparametric study on biocompatibility

Understanding the impact of divalent cation substitution on hydroxyapatite: An in vitro multiparametric study on biocompatibility

Evaluation of the in vivo biocompatibility of hydroxyapatite granules incorporated with zinc ions

Structural and luminescent properties of new Pb²⁺-doped calcium chlorapatites Ca_10−xPb_x(PO₄)₆ Cl₂ (0≤x≤10)

Contact Info

Product

Resources

About

Structural and spectroscopic characterizations in Pb2+-doped calcium hydroxyapatites

Cited by 15 publications

References 16 publications

Understanding the impact of divalent cation substitution on hydroxyapatite: An in vitro multiparametric study on biocompatibility

Understanding the impact of divalent cation substitution on hydroxyapatite: An in vitro multiparametric study on biocompatibility

Evaluation of the in vivo biocompatibility of hydroxyapatite granules incorporated with zinc ions

Structural and luminescent properties of new Pb2+-doped calcium chlorapatites Ca10−xPbx(PO4)6 Cl2 (0≤x≤10)

Contact Info

Product

Resources

About

Structural and luminescent properties of new Pb²⁺-doped calcium chlorapatites Ca_10−xPb_x(PO₄)₆ Cl₂ (0≤x≤10)