Structural and photoactive properties of self-assembled peptide-based nanostructures and their optical bioapplication in food analysis

Zhu, Xuecheng; Duan, Ruixue; Chan, Siew Yin; Han, Luxuan; Liu, Huilin; Sun, Baoguo

doi:10.1016/j.jare.2022.02.001

Cited by 5 publications

(3 citation statements)

References 144 publications

(164 reference statements)

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“…This approach has the potential to increase the effectiveness of chemotherapy by specifically targeting tumor vasculature, which plays a critical role in tumor growth and metastasis. In addition to passive targeting, nanoparticles can also be actively targeted by conjugating them with antibodies, peptides, aptamers, and small compounds [ 97 ]. The success of active targeting depends on interactions between the nanocarriers and the tumor microenvironment, multi-partite symbiosis, and the immune system.…”

Section: Strategies For Using Nanoparticles To Target Individual Canc...mentioning

confidence: 99%

“…Using a "polymercore/lipid shell" (a combination of polymers and phospholipids) as a delivery agent may allow for the synchronized release of two distinct drugs [96]. Once the nanoparticle has been localized to the tumor site through the EPR effect, it will begin to produce both an anti-angiogenesis agent from its outer phospholipid shell and a chemotherapeutic substance from its inner polymeric nanoparticle in response to local hypoxia [97]. Reduced toxicity and improved anti-metastatic effects were shown in two different mouse tumor models using this approach, demonstrating the value of a mechanism-based design for targeted nanocarriers [96].…”

Section: Apoptosis and Necrosismentioning

confidence: 99%

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Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Chehelgerdi,

Allela

et al. 2023

Mol Cancer

170

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The use of nanotechnology has the potential to revolutionize the detection and treatment of cancer. Developments in protein engineering and materials science have led to the emergence of new nanoscale targeting techniques, which offer renewed hope for cancer patients. While several nanocarriers for medicinal purposes have been approved for human trials, only a few have been authorized for clinical use in targeting cancer cells. In this review, we analyze some of the authorized formulations and discuss the challenges of translating findings from the lab to the clinic. This study highlights the various nanocarriers and compounds that can be used for selective tumor targeting and the inherent difficulties in cancer therapy. Nanotechnology provides a promising platform for improving cancer detection and treatment in the future, but further research is needed to overcome the current limitations in clinical translation. Graphical Abstract

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Section: Strategies For Using Nanoparticles To Target Individual Canc...mentioning

confidence: 99%

Section: Apoptosis and Necrosismentioning

confidence: 99%

Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Chehelgerdi,

Allela

et al. 2023

Mol Cancer

170

View full text Add to dashboard Cite

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“…Proteins are made up of one or more chains of polypeptides that contain various amino acid sequences. Polypeptide assemblies are often related to pathological events that also represent a captivating category of nanomaterials with increasingly significant bioapplications, such as regenerative medicine, drug delivery, and biodiagnosis. − Polypeptide molecules possess the self-assembly ability, giving rise to a wide array of nanostructures, such as nanofibers, nanotubes, nanotapes, nanospheres, and micelles in special solvents. , The basic biophysical properties of self-assembled polypeptides will hinge on their chemical composition and also conformational structures . Therefore, the rational design and manipulation of the morphology, structure, and functionality of polypeptide self-assemblies have emerged as indispensable pursuits recently. , …”

mentioning

confidence: 99%

Dual-Mode Arginine Assay Based on the Conformation Switch of a Ferrocene-Grafted Polypeptide

Wu,

Zhu,

Xue

et al. 2024

Anal. Chem.

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Exploring the Modern Bioactive Peptides (BAPs) Universe: Doors to the Future

Patil

2024

Peptide Science

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Because of their wide variety of biological effects, bioactive peptides (BAPs) have recently attracted a lot of attention. BAPs have been observed to be safe, thanks to their widely acknowledged safety status by the United States Food and Drug Administration (USFDA). This has led to their widespread use in various industries, such as food and nutrition, pharmaceuticals, and therapeutics. A considerable amount of research has been devoted to developing cutting‐edge nanomaterials derived from BAPs, which have been utilized in a wide range of industries. In the realm of scientific research, the remarkable ability of BAPs to self‐assemble has been harnessed to develop a wide range of nanoassemblies. These nanoassemblies hold immense potential for the advancement of biomaterials in the future. Research interest continues to focus on the study of the detection of BAPs using artificial intelligence (AI). Over the past few years, there has been a surge of interest in utilizing bio‐inspired strategies to explore new possibilities in the development of advanced energy devices and storage solutions. However, these strategies require scientific attention. This extensive review offers a broad perspective on the applications of BAPs in nanotechnology as well as pharmaceuticals and therapeutics. Moreover, in silico analysis of BAPs, coupled with ‐omics techniques, has been discussed. In the bargain, the next‐generation approaches in BAP research comprising BAP‐based energy devices, as well as BAPs in AI, have been catalogued. There is a considerable emphasis on developing more eco‐friendly energy‐storage technologies that draw inspiration from nature and use BAPs.

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Structural and photoactive properties of self-assembled peptide-based nanostructures and their optical bioapplication in food analysis

Cited by 5 publications

References 144 publications

Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Dual-Mode Arginine Assay Based on the Conformation Switch of a Ferrocene-Grafted Polypeptide

Exploring the Modern Bioactive Peptides (BAPs) Universe: Doors to the Future

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