Structural and molecular alterations in arsenic-induced hepatic oxidative stress in rats: a FTIR study

Prakāsh, Chandra; Kamboj, Vipan Kumar; Ahlawat, Pooja; Kumar, Vijay

doi:10.1080/02772248.2015.1102425

Cited by 17 publications

(13 citation statements)

References 39 publications

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“…In addition, the peak centered at 1648.5 cm -1 corresponding to vibrational modes of N-H, C=O, C=C, and Si-H 2 O bonds have shifted to 1647 cm -1 indicating modifications in the miR146a bases (48). These changes in the band area around 1526-1836 cm -1 (peak center at 1648.5 cm -1 ) and the observed shift can also be a sign of oxidation and reduction of the bases of miRNA due to the presence of ROS (49). For AuNP-miRN146a, we can see (Figure 7.b) that the peak around the band from 976-1176 cm -1 , centered at 1019 cm -1 , has been changed after H 2 O 2 incubation.…”

Section: Ftir Analysismentioning

confidence: 95%

Assessing the bio-stability of microRNA-146a conjugated nanoparticles via electroanalysis

et al. 2023

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Section: Ftir Analysismentioning

confidence: 95%

Assessing the bio-stability of microRNA-146a conjugated nanoparticles via electroanalysis

et al. 2023

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“…The drug entrapment efficiency (%) and yield (%) were calculated using Equation 1 and 2, respectively. FTIR spectrophotometer FTIR spectroscopy is a simple, sensitive, and multidimensional analytical tool used for recognizing changes in functional groups of pharmaceuticals [19]. FTIR spectra of SAF127, PVA, pure metformin, physical mixture, and MN were taken separately by KBr Pellet method using Bruker (1-206-0280; software: OPUS-7.2.139.1294, MENTOR) spectrophotometer.…”

Section: Entrapment Efficiency and Percentage Yieldmentioning

confidence: 99%

“…Nanoparticulate pharmaceutical formulations have properties of improved bioavailability, controlled, and prolonged drug release time with efficacy, safety and predicted therapeutic effect [5,16]. Various natural, synthetic, and semi-synthetic polymers have been investigated as a drug carrier to utilize the benefits of nanotechnology in formulations [6,[16][17][18][19][20][21]. There is a persistent effort among the researchers to improve the formulation of metformin to attain optimal therapeutic response.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Metformin Loaded Stearic Acid Coupled F127 Nanoparticles

Kamboj

Verma

2018

Asian J Pharm Clin Res

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Objective: The objective of this study was to prepare and evaluate metformin nanoparticles (MN) using stearic acid-coupled F127 (SAF127) copolymer and polyvinyl alcohol by emulsion solvent evaporation technique.Method: Metformin is the first-line drug for the treatment of type II diabetes mellitus belongs to Biopharmaceutical Classification System Class III. The prepared MN was characterized for particle size, polydispersity index (PDI), zeta potential, drug entrapment, percentage yield, in vitro drug release, and stability studies. The compatibility studies were performed by Fourier transform infrared (FTIR) and differential scanning calorimetry (DSC). The crystallographic and surface properties were studied by X-ray diffractometry and scanning electron microscopy, respectively.Results: The mean particle diameter of prepared nanoparticles ranged from 207.8 to 977.64 nm, PDI value ranged from 0.146 to 0.694, and zeta potential ranged from −20.5 to −6.97 mV. The drug entrapment efficiency of these nanoparticles varies between 18.81 to 69.01 %. The drug to SAF127 copolymer (10/30 w/w) ratio (MN3) showed optimum results. The MN3 had spherical morphology with semi-amorphous nature. The results of FTIR and DSC analysis showed that there was no significant interaction between drug and excipients. The prepared polymeric nanoparticles were stable at 5±3°C up to 3 months. In vitro release of drug from MN3 was 20.52% in the first 1 h and remaining drug was released up to 30 h.Conclusion: The results of this study confirmed the sustained drug release profile of metformin loaded SAF127 copolymer nanoparticles. These nanoparticles can be best stored up to 3 months.

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“…Acetazolamide, methazolamide, and megazol are thiadiazole containing drugs available in the market [7]. Oxidative stress is one of the major causes of various pathological diseases like diabetics, cancer, atherosclerosis, rheumatoid arthritis, chronic inflammation, cardiovascular diseases, and myocardial infarction [9,14]. The extensive literature survey reveals that the [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazole heterocyclic ring has gained much attention during last few years due to their high utilization as antimicrobial, anti-inflammatory, antioxidant, anticancer, antianxiety, sedatives, and anticonvulsant potential.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Antimicrobial, and Antioxidant Screening of Aryl Acetic Acid Incorporated 1,2,4‐Triazolo‐1,3,4‐Thiadiazole Derivatives

Kumar

Kapoor

Jain

2019

Journal of Heterocyclic Chem

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in Wiley Online Library (wileyonlinelibrary.com).Some novel [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazole derivatives were synthesized from aryl acetic acids. All the synthesized derivatives were selected for the screening of antibacterial potential against Grampositive bacteria [Staphylococcus aureus (MTCC 3160) and Micrococcus luteus (MTCC 1538)] and Gram-negative bacteria [Escherichia coli (MTCC 1652) and Pseudomonas aeruginosa (MTCC 424)] and antifungal potential against Aspergillus niger (MTCC 8652) and Candida albicans (MTCC 227), and free radical scavenging activity through 2,2-diphenyl-2-picrylhydrazyl hydrate method. The compounds TH-4, TH-13, and TH-19 were found to be more potent antimicrobial agents compared to standard drugs. The compounds TH-3, TH-9, and TH-18 also showed significant antimicrobial activity. The compound TH-13 showed antioxidant activity with IC 50 value better than the standard compound. The structures of all the synthesized compounds were confirmed by Fourier transform infrared, 1 H-NMR, liquid chromatography-mass spectrometry, and CHN analyzer.

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Structural and molecular alterations in arsenic-induced hepatic oxidative stress in rats: a FTIR study

Cited by 17 publications

References 39 publications

Assessing the bio-stability of microRNA-146a conjugated nanoparticles via electroanalysis

Assessing the bio-stability of microRNA-146a conjugated nanoparticles via electroanalysis

Preparation and Characterization of Metformin Loaded Stearic Acid Coupled F127 Nanoparticles

Synthesis, Antimicrobial, and Antioxidant Screening of Aryl Acetic Acid Incorporated 1,2,4‐Triazolo‐1,3,4‐Thiadiazole Derivatives

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