Structural and Mechanistic Usage and Preference of Human, Dog, and Bat Receptors by Rabies Virus
Manar E. Khalifa,
Mustafa Atasoy,
Mohammed Rohaim
et al.
Abstract:Rabies is a lethal zoonotic viral disease causing approximately 59,000 human deaths annually. Recently, several cellular receptors for rabies virus (RABV) entry and internalization have been identified. However, none of these receptors have been demonstrated to be indispensable for RABV entry. Here we describe the RABV receptor preferencein vivo, utilizing a replication-competent vesicular stomatitis virus (VSV), in which the VSV surface glycoprotein was replaced with rabies virus glycoprotein. To investigate … Show more
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