Structural and mechanical properties of the coral and nacre and the potentiality of their use as bone substitutes

Hamza, Samir; Slimane, N.; Azari, Z.; Pluvinage, G.

doi:10.1016/j.apsusc.2012.10.049

Cited by 30 publications

(14 citation statements)

References 30 publications

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“…The value of b was received by normalized fitting [33] as 4 Â 10 5 . The fatigue limit obtained here is quite close to the fatigue limit (15 MPa) of the natural nacre estimated by Hamza et al [34] though it is much lower than that of the typical engineering alloys. [3] The lower value may result from the thicker TiO 2 layers in the NLCs even if the strength of the NLCs was evidently enhanced.…”

Section: Critical Cracking Resistancesupporting

confidence: 87%

Fatigue and Fracture Reliability of Shell‐Mimetic PE/TiO₂ Nanolayered Composites

et al. 2017

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Shell-mimetic (PE/TiO 2 ) 4 nanolayered composites stacked alternatively by 20 nm-thick PE layers and 55 nm-thick nanocrystalline TiO 2 layers are synthesized by a combination of the layer-by-layer self-assembly and the chemical bath deposition methods. The critical cracking strain and the apparent fracture energy of the bio-mimetic nanolayered composites are determined as 0.56% and 0.98 J m À2 , respectively, by the simply supported beam bending testing. Fatigue properties of the (PE/TiO 2 ) 4 nanolayered composites are evaluated by the dynamic bending testing method. The critical fatigue strain amplitude corresponding to the lowest strain amplitude for fatigue cracking of the present (PE/TiO 2 ) 4 NLCs is 0.0853%, which is much lower than the critical cracking strain (0.56%) under monotonic bending. The finding indicates that the potential fatigue threat to the long-term reliability of the bio-mimetic nanolayered composites needs to be concerned.

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Section: Critical Cracking Resistancesupporting

confidence: 87%

Fatigue and Fracture Reliability of Shell‐Mimetic PE/TiO₂ Nanolayered Composites

et al. 2017

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“…Nacre can be easily obtained from the shell of several varieties of giant oysters such as Pinctada maxima . The material is composed of aragonite (a variety of calcium carbonate) and presents excellent compressive stress properties close from bone mechanical properties (Young's modulus is 30–40 GPa for nacre vs 20 GPa for bone, and resistance to failure is 185–200 MPa vs 140 MPa for bone) . Because of its layered architecture alternating between a mineral component and an organic component, the biomaterial presents a lamellar structure particularly adapted to the absorption and distribution of the forces and impacts opposing rupture.…”

Section: Introductionmentioning

confidence: 99%

The interface between nacre and bone after implantation in the sheep: a nanotomographic and Raman study

Pascaretti-Grizon

Libouban

Camprasse³

et al. 2014

J Raman Spectroscopy

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Orthopedic bone devices can be prepared from the shells of giant pearl oysters. Nacre is biocompatible and composed of calcium carbonate (aragonite). Direct welding of bone onto the biomaterial surface has been reported but poorly investigated. Nacre from Pinctada maxima was used to prepare plates, screws and rods. Five sheep were implanted in the first metatarsus under general anesthesia and killed 2 months later. Bones were harvested and fixed in formalin. Analysis was performed by nanotomography and histology after embedding in poly(methyl methacrylate). Polished sections were imaged by scanning electron microscopy then analyzed on a Raman microscope. Nanotomography and histology evidenced the newly apposed bone composed of thin trabeculae with a lower mineralization than mature bone. Erosion of the nacre was also easily observed. The bone/nacre interface presented a characteristic toothed‐comb appearance. Raman spectroscopy identified the typical bands of aragonite (1091 and 711 cm−1) in the devices. At a distance from the interface, the bone matrix presented the typical bands of hydroxyapatite at 960, 1044 and 594–610 cm−1 with the amide bands of collagen at 1250 cm−1. At the bone/nacre interface, a phosphate‐rich layer was observed without proteins. The newly formed bone units exhibited a band at 1075 cm−1 corresponding to a high amount of B‐carbonate substitution. The carbonate/phosphate ratio decreased between new and mature bone, and crystallinity was improved. Raman spectroscopy confirmed the modifications of the bone matrix around the nacre implant and the direct apposition of bone without an interposing organic layer between the calcium carbonate (nacre) and the calcium phosphate (hydroxyapatite). Copyright © 2014 John Wiley & Sons, Ltd.

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“…In vivo and in vitro studies indicate the nacre as a biocompatible, biodegradable and osteocondutive material, which may attract and activate bone marrow stem cells and osteoblasts; the same was observed in biogenic aragonite [22][23][24][25][26][27][28][29][30][31][32][33][34][35] . The mechanical and tribological properties -as tensile, compression and bending strength, besides resistance to abrasion -of the nacre, comparatively better than that of pure aragonite, are due to its hierarchical structure of micrometric hexagonal tablets with mineral bridges and interlocking surfaces 36,[38][39][40][41][42] and cemented in organic matrix. Considering that to this matrix are also attributed mineralizing and osteogenic properties 22,[30][31][32][33][34] , the hypothesis raised initially was that the nacre would present more pronounced osteogenic properties than the aragonite, disregarding this study any differences in the mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Nacre Compared to Aragonite as a Bone Substitute: Evaluation of Bioactivity and Biocompatibility

Almeida¹,

Silva²,

Nakamura³

et al. 2015

Mat. Res.

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Aragonite is a metastable polymorph of calcium carbonate found in mollusk's shells, appearing in tiles and prismatic columns, cemented in a protein matrix -mainly proteins -that acts as a framework on which the aragonite is nucleated forming nacre, besides selecting the morphology of the nucleated cristaline phase. The presence of the mineralyzing organic matrix may affect osteoinductive properties of biogenic aragonite, hypothesis tested by combinated tests, comparing viability and bioactivity of biomineralizated aragonite and nacre. Bioactivity was observed by deposition of Ca-P (presumably calcium phosphate) on the surface of samples immersed in Simulated Body Fluid; biocompatibility was verified by adhesion with VERO cells; cytotoxicity and alkaline phosphatase activity assays were performed with human adipose stem cells (hASC). Samples were characterized by scanning electron microscopy and X-ray diffraction. Both materials showed similar behaviour on bioactivity assay; in contrast, exhibited different behaviours in the presence of hASC.

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Structural and mechanical properties of the coral and nacre and the potentiality of their use as bone substitutes

Cited by 30 publications

References 30 publications

Fatigue and Fracture Reliability of Shell‐Mimetic PE/TiO₂ Nanolayered Composites

Fatigue and Fracture Reliability of Shell‐Mimetic PE/TiO₂ Nanolayered Composites

The interface between nacre and bone after implantation in the sheep: a nanotomographic and Raman study

Nacre Compared to Aragonite as a Bone Substitute: Evaluation of Bioactivity and Biocompatibility

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Structural and mechanical properties of the coral and nacre and the potentiality of their use as bone substitutes

Cited by 30 publications

References 30 publications

Fatigue and Fracture Reliability of Shell‐Mimetic PE/TiO2 Nanolayered Composites

Fatigue and Fracture Reliability of Shell‐Mimetic PE/TiO2 Nanolayered Composites

The interface between nacre and bone after implantation in the sheep: a nanotomographic and Raman study

Nacre Compared to Aragonite as a Bone Substitute: Evaluation of Bioactivity and Biocompatibility

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Fatigue and Fracture Reliability of Shell‐Mimetic PE/TiO₂ Nanolayered Composites

Fatigue and Fracture Reliability of Shell‐Mimetic PE/TiO₂ Nanolayered Composites