Structural and mechanical characterization of custom design cranial implant created using additive manufacturing

Moiduddin, Khaja; Darwish, S.M.; Al-Ahmari, Abdulrahman; Elwatidy, Sherif; Mohammad, Ashfaq; Ameen, Wadea

doi:10.1016/j.ejbt.2017.06.005

Cited by 71 publications

(48 citation statements)

References 26 publications

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“…• Report results openly, both negative and positive, to ensure that mistakes are not repeated Open porous scaffold with rectangular strut: width 400 µm and height 800 µm Bone formation Triangular, hexagonal and rectangular pore shapes; 500 and 1000 µm pore size; strut size 200 µm; stiffness from 0.45 to 11 GPa Small pores -initial cell attachment; large non-circular pores -avoid pore occlusion *not strictly an AM porosity, but an AM feature that creates a non-solid area to improve implant stability. 1 2 Ti-6Al-4V 8, 11, 14, 15, 22, 27, 36, 40, 42-44, 48, 49, 55, 57, 58, 67, 70 Ti-6Al-4V ELI 10,19,20,25,35,37,39,52 Co-28Cr-6Mo…”

Section: Discussionmentioning

confidence: 99%

“…Porous structures are utilised in medicine to enable targeted drug delivery [97], mechanically match an implant strength to surrounding bone [36], reduce the amount of material and weight [11], promote osseointegration [35], and allow fluid transfer [60]. Various commercial non-AM porous materials are currently available, for example Zimmer's Trabecular Metal TM Technology [98].…”

Section: Porosity Of Solidmentioning

confidence: 99%

“…Case study [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] Clinical animal study 2 27,28 Applied non-clinical 10 [29][30][31][32][33][34][35][36][37][38] Animal study 14 [39][40][41][42][43][44][45][46][47][48][49][50][51][52] Fundamental science 19 53…”

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confidence: 99%

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Reporting fidelity in the literature for computer aided design and additive manufacture of implants and guides

Burton

Peel

Eggbeer

2018

Additive Manufacturing

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The aim of this study was to critically evaluate the nature and reporting fidelity of literature about applications of computer aided design (CAD) and metal additive manufacture (AM) to surgical guides and implants. Increasingly, non-specialist designers such as surgeons or prosthetists are partaking in some or all of the design process. To comply with local regulations, it is imperative that quality is ensured during the design process, yet it is rare for literature to report on the design process of medical devices with sufficient detail to allow proper evaluation or reproduction. This study reviewed the CAD/AM literature for implant and guide design, focussing on detailed justifications for design decisions, economic impacts, and production methods. This review showed that the fidelity of reporting in the literature was low; with opportunities to report crucial design decisions, engineering parameters, and how these relate to clinical results being frequently missed. This research proposes the low fidelity in reporting is likely due to a combination of: reporting for different specialisms, resulting in a lack of expert knowledge in certain areas and assumed knowledge in others; commercial sensitivity of design and manufacturing methods; low volume of clinical cases; and a large gap in translating research to clinical applications. This study concluded that higher fidelity in reporting methods are required when discussing the design of AM medical implants, which would allow comparisons between studies, provide evidence to support design quality, and enable evidence-based decision-making.

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Section: Discussionmentioning

confidence: 99%

Section: Porosity Of Solidmentioning

confidence: 99%

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Reporting fidelity in the literature for computer aided design and additive manufacture of implants and guides

Burton

Peel

Eggbeer

2018

Additive Manufacturing

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“…Such made voxel models of the cranial implants are usually exported to destination general file format, such as STL. This format is useful for CNC (Computerized Numerical Control) milling machine as well as for 3D printing -to produce useful material models or target implant [1,3,17].…”

Section: Discussionmentioning

confidence: 99%

Hybrid Modeling Methods of Cranial Implants

Wyleżoł¹

2018

Adv. Sci. Technol. Res. J.

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This article deals with a three hybrid modeling methods of virtual skull implants, developed by the author. 3D models of cranial implants are nowadays necessary for the creation of real implants using modern manufacturing technologies. These methods combine simultaneous usage of three modeling systems (which causes their hybridity): computer tomography system (as a reverse engineering system), surface modeling system and haptic modeling system, and their characteristic modeling methods and techniques. Whereby to commonly used three different modeling systems we have obtained a synergic effect of the implant shape model quality increasing. The result of using the developed hybrid methods are models of exemplary cranial implants. The common feature of these methods is that the target virtual model of the cranial implant is always well-suited the coastline of bone hole in the skull. The time of developed of the virtual model of any cranial implant using proposed methods is very shorter compared to use only one of the standard (not medically specialized) computer-aided systems. Similarly, the amount of modeling work is also much smaller than using only one standard 3D system. The article describes hybrid modeling methods developed by the author only.

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“…Due to recent advancements in image processing, EBM technology has facilitated the custom design of complex functional parts based on scanned image data, such as CT and magnetic resonance imaging (MRI). Published literature demonstrates the suitability of EBM-produced titanium implants in biomedical and clinical applications [3,4]. EBM-fabricated mesh implants provide good osteoconductive properties and promote full bone-ingrowth when compared to bulk parts [5,6].…”

Section: Introductionmentioning

confidence: 99%

An In Vivo Evaluation of Biocompatibility and Implant Accuracy of the Electron Beam Melting and Commercial Reconstruction Plates

Moiduddin

Mian

Alkindi

et al. 2019

Metals

Self Cite

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The use of additive manufacturing in medical applications has become more prevalent over the last decade. Studies have proved that reconstruction plates with a mesh structure enhance the biocompatibility and bone-ingrowth formation. However, limited studies have been reported in the customization and in vivo clinical assessment of mesh implants. The purpose of this study was to investigate the surgical treatment and implant fitting accuracy using three different reconstruction plates. Fifteen goats were divided into one control and three experimental groups (Groups 1, 2, and 3) with five in each group. An experimental segmental defect was created on these animals and was adopted with customized electron beam melting reconstruction titanium plates with mesh in Group 1 and without mesh in Group 2 and commercial reconstruction plate in Group 3. All the animals were subjected to radiographic analysis before and after surgery. The subjected animals were sacrificed after 3 months and the electron beam melting reconstruction plates were compared with the commercial plate based on clinical and histology analysis and implant fitting accuracy. Both the electron beam melting reconstruction plates (with mesh and without mesh) and commercial plates survived the three months post-operation, revealing good wound-healing with new bone formation and without any foreign-body reaction. The electron beam melting reconstructed plate with mesh (Group 1) was found to have a better implant fitting when compared to the other two groups. The average discrepancy between Groups 2 and 3 was not significant. Certainly, the commercial plate (Group 3) was found to have the least accuracy as compared to other electron beam melting reconstruction plates (Group 1 and Group 2). Custom design electron beam melting fabricated reconstruction plates possessed better functionality, aesthetic outcome, and long-term biocompatibility when compared to commercial plates. Animal results indicated that the electron beam melting plates with mesh (Group 1) were superior in comparison to the other two groups due to its ability to provide better bone-in-growth and osseointegration on its porous microstructure.

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Structural and mechanical characterization of custom design cranial implant created using additive manufacturing

Cited by 71 publications

References 26 publications

Reporting fidelity in the literature for computer aided design and additive manufacture of implants and guides

Reporting fidelity in the literature for computer aided design and additive manufacture of implants and guides

Hybrid Modeling Methods of Cranial Implants

An In Vivo Evaluation of Biocompatibility and Implant Accuracy of the Electron Beam Melting and Commercial Reconstruction Plates

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