Structural and material approaches to bone tissue engineering in powder-based three-dimensional printing

Butscher, A.; Bohner, Marc; Hofmann, Sandra; Gauckler, Ludwig J.; Müller, Ralph

doi:10.1016/j.actbio.2010.09.039

Cited by 398 publications

(294 citation statements)

References 107 publications

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“…It's known that filling the bone defect with a porous scaffold helps to enhance bone regeneration since the scaffold serves as a template for cell ingrowth and interactions as well as for extracellular bone matrix formation [5]. Conventional methods for scaffold fabrication such as gas foaming, salt leaching, fiber meshing and emulsification are widespread, but they cannot produce a scaffold with full control of geometrical parameters (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Conventional methods for scaffold fabrication such as gas foaming, salt leaching, fiber meshing and emulsification are widespread, but they cannot produce a scaffold with full control of geometrical parameters (e.g. pore size and interconnected porosity) [5,6]. It has been shown that 3D porous scaffolds, reproducing the shape of the patient's bone defect, have a great biocompatibility after the surgical procedure [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Direct-write assembly of 3D scaffolds using colloidal calcium phosphates inks

et al. 2014

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Additive manufacture techniques using concentrated colloidal inks are a promising approach for creating three-dimensional (3D) calcium phosphates scaffolds for bone repair and regeneration. Among those, the direct-write assembly allows building scaffolds with precise size and geometry. In the present work, commercial β-TCP and HA were used to produce two types of colloidal ink. According to the ink composition used to build the scaffolds, two different groups were obtained. Group I: scaffolds produced with β-TCP-based ink; and Group II: scaffolds produced with biphasic CaP-based ink (BCP). The 3D scaffolds were assembled in a cylindrical shape (Φ = 8mm x H= 16 mm) with interconnected pore channels of approximately 500μm by robotic deposition of 64 layers using a robocasting machine. The mechanical compression property of the scaffolds was determined using universal testing machine. To assure the controlled geometry of the scaffolds, digital images were obtained by reconstructing each individual scan obtained with a micro-computed tomography. An optical contact angle measurement system was used to evaluate the wettability of the materials. After analyzing the results it was concluded that: the robocasting system is suitable for building 3D periodic calcium phosphates scaffolds; the direct-write assembly didn't change the hydrophilic characteristic of CaPs; and presented mean compressive strength around 11 MPa (β-TCP group) and 15 MPa (BCP group), which is compatible with trabecular bone.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Direct-write assembly of 3D scaffolds using colloidal calcium phosphates inks

et al. 2014

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“…However, negative effects typical of fine particles are sometimes encountered e.g. poor flow, agglomeration, undesired sintering [4,12], difficulty to remove the unsintered powder from the manufactured products or fogging of the optical elements inside the system [13].…”

Section: Introductionmentioning

confidence: 99%

Morphology of polymeric powders in Laser Sintering (LS): From Polyamide to new PEEK powders

Berretta

Ghita

Evans

2014

European Polymer Journal

107

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In an attempt to expand the range of engineering polymers used for laser sintering, this paper examines the morphology, flowability and interparticle interactions of two commercially available poly (ether ether) ketone (PEEK) powders, not yet optimised for the LS process, by comparison with the LS optimised Polyamide (PA) and Polyetherketone (PEK) powdered polymers . The effect of incorporating fillers and additives on the flow behaviour is also analysed. The Particle Size Distribution (PSD) results alone do not allow ranking the powder materials in relation to the flow behaviour. The particle morphology has a stronger influence on the flow characteristics for materials with similar PSDs. The work also provides additional characterization parameters to be considered when analysing LS powders. Graphical abstract

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“…Bioactive materials used for tissue regeneration should be highly porous to induce cell migration, nutrient transportation and tissue ingrowth. [19][20][21][22] Thus, we hypothesized that a porous MoS 2 scaffold may be able to treat large tumor-induced bone defects by harnessing its inherent photothermal properties and the osteogenic potential of porous scaffolds.…”

Section: Introductionmentioning

confidence: 99%

A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration

Wang

et al. 2017

NPG Asia Mater

126

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The treatment of malignant bone tumors is a significant clinical challenge because it requires the simultaneous removal of tumor tissues and regeneration of bone defects, and bifunctional three-dimensional (3D) scaffolds that function in both tumor therapy and tissue regeneration are expected to address this need. In this study, novel bifunctional scaffolds (MS-AKT scaffolds) were successfully fabricated by combining a 3D printing technique with a hydrothermal method. During the hydrothermal process, MoS 2 nanosheets were grown in situ on the strut surface of bioceramic scaffolds, endowing them with photothermal therapeutic potential. Under near-infrared (NIR) irradiation, the temperature of the MS-AKT scaffolds rapidly increased and was effectively modulated by varying the MoS 2 content, scaffold sizes and laser power densities. The photothermal temperature significantly decreased the viability of osteosarcoma cells and breast cancer cells and inhibited tumor growth in vivo. Moreover, the MS-AKT scaffolds supported the attachment, proliferation and osteogenic differentiation of bone mesenchymal stem cells and induced bone regeneration in vivo. This bifunctional scaffold, which treats the tumor and facilitates bone growth, offers a promising clinical strategy to treat tumor-induced bone defects. This proof-of-concept study demonstrates the feasibility of localized tumor therapy and tissue regeneration in diverse tissue engineering applications using multifunctional biomaterials.

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Structural and material approaches to bone tissue engineering in powder-based three-dimensional printing

Cited by 398 publications

References 107 publications

Direct-write assembly of 3D scaffolds using colloidal calcium phosphates inks

Direct-write assembly of 3D scaffolds using colloidal calcium phosphates inks

Morphology of polymeric powders in Laser Sintering (LS): From Polyamide to new PEEK powders

A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration

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