Structural and immunogenomic insights into B-cell receptor activation

Feng, Yangyang; Wang, Yu; Zhang, Shaocun; Haneef, Kabeer; Liu, Wanli

doi:10.1016/j.jgg.2019.12.003

Cited by 9 publications

(10 citation statements)

References 103 publications

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“…BCRs expressed on mature B cells are membrane-bound immunoglobulin molecules that are activated following antigen-induced aggregation 32 . Although several different models have been proposed for BCR activation, considerable evidence suggests that BCRs undergo activation-dependent localization to membrane microdomains, probably facilitating higher-order BCR clustering and signal transduction 33 , 34 . Upon activation, some B cells become plasma cells, which switch from primarily expressing membrane-associated IgM to abundantly secreting it by a mechanism of alternative RNA processing 35 .…”

Section: The Role Of Avidity In Antibody Biologymentioning

confidence: 99%

Avidity in antibody effector functions and biotherapeutic drug design

Oostindie

Lazar²,

Schuurman

et al. 2022

Nat Rev Drug Discov

103

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Section: The Role Of Avidity In Antibody Biologymentioning

confidence: 99%

Avidity in antibody effector functions and biotherapeutic drug design

Oostindie

Lazar²,

Schuurman

et al. 2022

Nat Rev Drug Discov

103

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“…In vivo studies have revealed that following interaction of external invading Ags with a surface-anchored receptor called the B cell receptor (BCR), a series of signal transduction events occurs via phosphorylation of the immunoreceptors tyrosine-based activation motif (ITAM) interlinked immunoglobulin (Ig)α, Igβ domains via underlying kinase phosphorylated spleen tyrosine kinase (pSyk) [2]. These events led to the subsequent recruitment of proximal signaling molecules and adaptor proteins to produce neutralizing Abs (NAbs) and develop immune memory [20,21]. B cell receptors (BCRs) configuration reveals noncovalent meticulous interactions of membrane-tethered with Igα, Igβ [21][22][23].…”

Section: Severe Acute Respiratory Syndrome Coronavirus 2 Targeted Antibodies Cocktail and B Cell Receptor Interplay: Interventions To Trimentioning

confidence: 99%

“…Following the interaction of Ags, BCR undergoes signal transduction events through phosphorylation of ITAMs to produce plasma cells to generate effective Abs [22]. BCRs delicate configuration possessed membrane-tethered Ig, non-covalently associated with Iga, Igβ domains (Figure 2) [20]. Following BCR interactions with SARS-CoV-2 structural Ags, BCRs undergo series of signal transduction events [20].…”

Section: B Cell Receptor Signaling and The Generation Of Protective Abs During Sars-cov-2 Infectionmentioning

confidence: 99%

“…BCRs delicate configuration possessed membrane-tethered Ig, non-covalently associated with Iga, Igβ domains (Figure 2) [20]. Following BCR interactions with SARS-CoV-2 structural Ags, BCRs undergo series of signal transduction events [20]. These events lead to several well-ordered molecular events, including isotype class switching, affinity maturation, and Ab production against SARS-CoV-2 [5,20,21].…”

Section: B Cell Receptor Signaling and The Generation Of Protective Abs During Sars-cov-2 Infectionmentioning

confidence: 99%

“…Following BCR interactions with SARS-CoV-2 structural Ags, BCRs undergo series of signal transduction events [20]. These events lead to several well-ordered molecular events, including isotype class switching, affinity maturation, and Ab production against SARS-CoV-2 [5,20,21]. BCR's intricate, methodical configuration reveals efficient capability to translate the external physical, chemical, and antigenic cues and harbor sophisticated mechanisms of generating chemical signal entities to reshape the immune mechanism [22,26].…”

Section: B Cell Receptor Signaling and The Generation Of Protective Abs During Sars-cov-2 Infectionmentioning

confidence: 99%

See 2 more Smart Citations

Severe acute respiratory syndrome coronavirus 2 targeted antibodies cocktail and B cell receptor interplay: interventions to trigger vaccine development

Haneef

Saleem²,

Khan

et al. 2021

Explor Immunol

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Coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2 spread globally and creates an alarming situation. Following the SARS-CoV-2 paradigm, therapeutic efficacy is achieved via repurposing several antiviral, antibacterial, and antimalarial drugs. Innate and adaptive immune cells work close to combat infection through the intricate production of antibodies (Abs) and inflammatory cytokines. As an essential component of the immune system, Abs play an important role in eliminating viruses and maintaining homeostasis. B lymphocytes (B cells) are effector cells, stringent to produce neutralizing Abs to combat infection. After recognizing SARS-CoV-2 antigens by a surface receptor called B cell receptors (BCRs) on the plasma membrane, the BCRs transmembrane signal transduction and immune activation results in Ab production and development of immune memory. Thus, it ensures that plasma B cells can quickly start an intricate immune response to generate efficient protective Abs to clear the pathogen. Nevertheless, considering therapeutic challenges in the context of the new coronavirus pandemic, this review addresses the molecular mechanism of the immune activation and function of novel SARS-CoV-2 specific B cells in the production of SARS-CoV-2 specific Abs. Additionally, these studies highlighted the Ab-mediated pathogenesis, the intriguing role of nano-scale signaling subunits, non-structural proteins during COVID-19 infection, and structural insights of SARS-CoV-2 specific Abs.

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DNA nanostructures as biomolecular scaffolds for antigen display

Chen

Jiang

et al. 2023

WIREs Nanomed Nanobiotechnol

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Nanoparticle‐based vaccines offer a multivalent approach for antigen display, efficiently activating T and B cells in the lymph nodes. Among various nanoparticle design strategies, DNA nanotechnology offers an innovative alternative platform, featuring high modularity, spatial addressing, nanoscale regulation, high functional group density, and lower self‐antigenicity. This review delves into the potential of DNA nanostructures as biomolecular scaffolds for antigen display, addressing: (1) immunological mechanisms behind nanovaccines and commonly used nanoparticles in their design, (2) techniques for characterizing protein NP–antigen complexes, (3) advancements in DNA nanotechnology and DNA–protein assembly approach, (4) strategies for precise antigen presentation on DNA scaffolds, and (5) current applications and future possibilities of DNA scaffolds in antigen display. This analysis aims to highlight the transformative potential of DNA nanoscaffolds in immunology and vaccinology.This article is categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Biology‐Inspired Nanomaterials > Protein and Virus‐Based Structures

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Structural and immunogenomic insights into B-cell receptor activation

Cited by 9 publications

References 103 publications

Avidity in antibody effector functions and biotherapeutic drug design

Avidity in antibody effector functions and biotherapeutic drug design

Severe acute respiratory syndrome coronavirus 2 targeted antibodies cocktail and B cell receptor interplay: interventions to trigger vaccine development

DNA nanostructures as biomolecular scaffolds for antigen display

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