Structural and Histologic Eyelid Changes Associated with 6 Months of Topical Bimatoprost in the Rabbit

Kent, Tiffany L.; Custer, Philip L.

doi:10.1097/ijg.0000000000000591

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…These observations were also supported by an animal model. 30 Ultrasound backscatter microscopy of the eyelids of patients receiving monocular PGA for glaucoma treatment demonstrated thinning of orbital tissue in 85% of cases. 31 Shah and colleagues 32 examined periocular findings in 172 patients with glaucoma who were current and former users of PGA drops.…”

Section: Prostaglandin-associated Periorbitopathymentioning

confidence: 99%

Revisiting the Safety of Prostaglandin Analog Eyelash Growth Products

Steinsapir¹,

Steinsapir²

2021

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BACKGROUND The FDA approved bimatoprost ophthalmic solution 0.03% for treatment of eyelash hypotrichosis in 2008. Consumer concern persists regarding potential side effects of this product. OBJECTIVE To identify gaps in the safety information associated with the use of prostaglandin eyelash growth products. MATERIALS AND METHODS Literature searches were performed using PubMed, Embase, and Nexis Uni databases without restriction to publication date, language, or study setting. RESULTS The literature pertaining to bimatoprost for treatment of eyelash hypotrichosis is dominated by industrysponsored clinical trials. Study design choices create gaps in our understanding of the clinical safety of these products. CONCLUSION Because of study design choice, clinical trials of bimatoprost for eyelash growth may have systematically underreported the incidence of drug application discomfort and prostaglandin-associated periorbitopathy. The risk of increased iris pigmentation remains inadequately investigated. Consequently, there is an ongoing need to educate and monitor patients who choose to use these products.

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Section: Prostaglandin-associated Periorbitopathymentioning

confidence: 99%

Revisiting the Safety of Prostaglandin Analog Eyelash Growth Products

Steinsapir¹,

Steinsapir²

2021

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“…2 In a subsequent publication, eyelid tightening and shortening associated to the use of bimatoprost was described in an experimental animal model. 13 The purpose of this study was to determine the effect of chronic topical use of PGF2α for glaucoma on lower eyelid tension in human patients.…”

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confidence: 99%

Lower Eyelid Horizontal Tightening in Prostaglandin Associated Periorbitopathy

Procianoy

Lang

Bocaccio

2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To determine the effect of chronic topical use of prostaglandin analogs for glaucoma on lower eyelid tension. Methods: A prospective case–control study was performed. Lower eyelid tension was measured in a group of glaucoma patients (73 eyelids) using prostaglandin analogs and a paired control group (87 eyelids). Seven glaucoma patients with unilateral use of prostaglandin analogs had the lower eyelid tension of the exposed side compared with the contralateral eyelid. Eyelid tension was digitally measured in photographs in neutral position and after manual downward traction in the center of the eyelid (modified distraction test). Duration of drug exposition, age, use of other topical medication and other prostaglandin-associated periorbitopathy signs as long eyelashes, eyelid hyperemia, eyelid pigmentation, and deepening of upper eyelid sulcus were recorded for analysis. Results: Mean lower eyelid tension in prostaglandin group was significantly higher than in control group: distraction 5.26 mm (SD 1.52) versus 6.80 mm (SD 1.29) (p < 0.001). On the unilateral prostaglandin use intragroup comparison, mean lower eyelid distraction in prostaglandin side was 4.24 mm (SD 1.80) and in control side was 6.79 mm (SD 1.63) (p < 0.012). Beta blocker and carbonic anhydrase inhibitor concomitant use was associated with lower eyelid tension measures in prostaglandin users. Presence of long eyelashes was associated with higher eyelid tension. All other measured variables did not demonstrate interaction with eyelid tension. Conclusions: Chronic topical use of prostaglandin analogs for glaucoma is associated with lower eyelid tightening.

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