“…In these "water co-transporters", osmolyte influx is immediately translated to water influx via the generation of small localized osmotic pressures (Duquette, Bissonnette, & Lapointe, 2001;Lapointe, Gagnon, Poirier, & Bissonnette, 2002). Water cotransporters are highly efficient, mediating 65% of intestinal water uptake (Zeuthen, Gorraitz, Her, Wright, & Loo, 2016), and have been shown to be associated with the majority of perisynaptic glutamate clearance (MacAulay, Hamann, & Zeuthen, 2004). Interestingly, certain water co-transporters, including the Na 1 /K 1 /2Clco-transporter-1 and volume-regulated anion channels, mediate cell volume changes in astrocytes (Nilius, 2004;Kimelberg, Macvicar, & Sontheimer, 2006;Jayakumar and Norenberg, 2010;Zeuthen, 2010).…”