Structural and Functional Peculiarities of Mast Cells in Undifferentiated Connective Tissue Dysplasia

Abstract

We performed an immunomorphological study of mast cells from undamaged skin in women with phenotypical evidence of undifferentiated connective tissue dysplasia syndrome, patients of cosmetological clinics. It was found that the numerical density of mast cells containing chymase granules in this condition 1.7-fold surpassed the corresponding parameter in patients without signs of connective tissue dysplasia syndrome, which probably was a result of compensatory and adaptive reaction aimed at activation of the synthesis of the connective tissue extracellular matrix components. It was hypothesized that increased content of chymase-positive mast cells in the skin of patients with connective tissue dysplasia syndrome contributed to the formation of associated arterial hypertension.

Unevenly distributed: a systematic review of the health literature about socioeconomic inequalities in adult obesity in the United Kingdom

“…Moreover, evidence in this context has suggested that women workers may be concentrated into fewer and lower-paid occupations per OSC classification than men [79]. Second, the OSC may not accurately identify the SEP of individuals outside of the market labor force, such as the unemployed, retired adults, children, and individuals employed in informal sectors, such as homemakers [81]. Although head-of-household OSC measures may be used as proxies for measuring SEP among individuals who fall into the above classifications, these proxies do not account for differences in family structure and/or dependency in relation to the head-of-household.…”

Abstracts and Citations

“…Of those receiving 10 mg or more of gluten daily, one had symptomatic relapse and several showed worsening CD on histological examination. 7 Yet the study concluded that, for patients with CD, the daily dietary intake of gluten should be <50 mg. 7 Note 10 mg in 500 g of food represents 20 ppm; 10 mg gluten is ingested in 1/250th of a slice of bread containing 2.5 g gluten. 4 Does any label tell us how much gluten is contained within said package?…”

“…6 These ASICs are a new migraine pharmacological target. 7 I presume it's only a matter of time before direct linkage is made between nervous tissue, immune cells, and pain, if I haven't already misrecognized it. Background and purpose: Migraine and irritable bowel syndrome (IBS) share many similarities characterized by their epidemiology, periodic pain, lack of definable organic causes, trigger factors, comorbidities, and proposed pathophysiology.…”

“…Last but not least, in 1 study of 42 CD patients on a GF diet (only possibly 0 mg and 0 ppm) received 0, 10, or 50 mg of gluten daily for 3 months. 4,7 Patients' duodenal mucosa were examined histologically before and after the gluten challenge. Of those receiving 10 mg or more of gluten daily, one had symptomatic relapse and several showed worsening CD on histological examination.…”

“…Pathology‐based assessment has demonstrated an increase in mast cell density and activity in the undifferentiated connective tissue samples of patients with connective tissue dysplasia suggesting an inflammatory component to symptoms of hypermobility. 7 Application of physiotherapy for joint hypermobility is routinely prescribed. This abstract provides data regarding a cognitive behavioral program within a multidisciplinary approach for patients with hypermobility.…”