Abstract:Neuronal lesions trigger mechanisms of structural and functional neuroplasticity, which can support recovery. However, the temporal and spatial appearance of structure-function changes and their interrelation remain unclear. The current study aimed to directly compare serial whole-brain in vivo measurements of functional plasticity (by [18F]-FDG-PET) and structural synaptic plasticity (by [18F]-UCB-H-PET) before and after bilateral labyrinthectomy in rats and investigate the effect of locomotor training. Compl… Show more
“…Although the details are still to be elucidated, it is becoming clear that the pedunculopontine tegmental nucleus, which is known to project to the striatum, is also connected to the vestibular nucleus; furthermore, it is evident that PD is associated with major changes in cholinergic pathways involving the vestibular system. The study by Antons et al (48) reinforces previous evidence that vestibular loss is associated with major functional changes in the striatum. Evidence continues to be reported that GVS can modulate the symptoms of PD (23).…”
Section: The Vestibular System and The Striatumsupporting
confidence: 81%
“…Antons et al (48) undertook a large longitudinal dual tracer study in rats following BVL, using positron emission tomography with computer tomography to measure functional and structural plasticity throughout the brain at 1, 3, 5, 7, and 9 weeks post-lesion. They found significant decreases in glucose metabolism in both the left and right striatum, coupled with increases in synaptic density.…”
Section: The Vestibular System and The Striatummentioning
Over the last two decades, evidence has accumulated to demonstrate that the vestibular system has extensive connections with areas of the brain related to spatial memory, such as the hippocampus, and also that it has significant interactions with areas associated with voluntary motor control, such as the striatum in the basal ganglia. In fact, these functions are far from separate and it is believed that interactions between the striatum and hippocampus are important for memory processing. The data relating to vestibular-hippocampal-striatal interactions have considerable implications for the understanding and treatment of Alzheimer's Disease and Parkinson's Disease, in addition to other neurological disorders. However, evidence is accumulating rapidly, and it is difficult to keep up with the latest developments in these and related areas. The aim of this review is to summarize and critically evaluate the relevant evidence that has been published over the last 2 years (i.e., since 2021), in order to identify emerging themes in this research area.
“…Although the details are still to be elucidated, it is becoming clear that the pedunculopontine tegmental nucleus, which is known to project to the striatum, is also connected to the vestibular nucleus; furthermore, it is evident that PD is associated with major changes in cholinergic pathways involving the vestibular system. The study by Antons et al (48) reinforces previous evidence that vestibular loss is associated with major functional changes in the striatum. Evidence continues to be reported that GVS can modulate the symptoms of PD (23).…”
Section: The Vestibular System and The Striatumsupporting
confidence: 81%
“…Antons et al (48) undertook a large longitudinal dual tracer study in rats following BVL, using positron emission tomography with computer tomography to measure functional and structural plasticity throughout the brain at 1, 3, 5, 7, and 9 weeks post-lesion. They found significant decreases in glucose metabolism in both the left and right striatum, coupled with increases in synaptic density.…”
Section: The Vestibular System and The Striatummentioning
Over the last two decades, evidence has accumulated to demonstrate that the vestibular system has extensive connections with areas of the brain related to spatial memory, such as the hippocampus, and also that it has significant interactions with areas associated with voluntary motor control, such as the striatum in the basal ganglia. In fact, these functions are far from separate and it is believed that interactions between the striatum and hippocampus are important for memory processing. The data relating to vestibular-hippocampal-striatal interactions have considerable implications for the understanding and treatment of Alzheimer's Disease and Parkinson's Disease, in addition to other neurological disorders. However, evidence is accumulating rapidly, and it is difficult to keep up with the latest developments in these and related areas. The aim of this review is to summarize and critically evaluate the relevant evidence that has been published over the last 2 years (i.e., since 2021), in order to identify emerging themes in this research area.
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