Structural and functional neuroimaging correlates of depression in temporal lobe epilepsy

Richardson, Elizabeth; Griffith, H. Randall; Martin, Roy C.; Paige, A. LeBron; Stewart, Christopher C.; Jones, Jana E.; Hermann, Bruce P.; Seidenberg, Michael

doi:10.1016/j.yebeh.2006.11.013

Cited by 64 publications

(53 citation statements)

References 48 publications

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“…There is also recent evidence demonstrating an association between reduced 5-HT(1A) receptor binding in the hippocampus and higher levels of self-reported depression in patients with TLE (61,62). In another study, a trend was noted for increased left amygdalar, but not hippocampal, metabolism to correlate with increased depression in TLE (21). Finally, there are data linking bilateral inferior frontal hypometabolism to depression in left TLE (63).…”

Section: Petmentioning

confidence: 93%

“…One study found that a reduction in left hippocampal volume was associated with depression in TLE, but only for patients with a rightsided seizure focus (20). In several studies, bilateral increases in amygdala volumes have been linked to depression and dysthymia in TLE (21)(22)(23). Increased amygdala volumes have also been associated with psychosis in epilepsy (24) and there is some evidence that amygdalar atrophy is associated with interictal affective aggression in TLE (25).…”

Section: Imaging Of Structure and Metabolites In Epilepsy 21 Volumetmentioning

confidence: 99%

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The use of neuroimaging to study behavior in patients with epilepsy

McDonald¹

2008

Epilepsy & Behavior

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Structural and functional neuroimaging continue to play an increasing role in the presurgical evaluation of patients with epilepsy. In addition to their value for localizing the epileptogenic zone and eloquent cortex, neuroimaging is contributing to our understanding of mood comorbidity in epilepsy. Although the vast majority of research has focused on patients with temporal lobe epilepsy (TLE), neuroimaging studies of patients with frontal lobe epilepsy (FLE) and primary generalized epilepsy are increasing in number. In this review, structural and functional imaging modalities that have received considerable research attention in recent years are reviewed, along with an assessment of their strengths and limitations for understanding behavior in epilepsy. In addition, advances in multimodal imaging are discussed along with their potential application to the presurgical evaluation of patients with seizure disorders.

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Section: Petmentioning

confidence: 93%

Section: Imaging Of Structure and Metabolites In Epilepsy 21 Volumetmentioning

confidence: 99%

The use of neuroimaging to study behavior in patients with epilepsy

McDonald¹

2008

Epilepsy & Behavior

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“…A subsequent study using three-dimensional surface mapping, also found significantly increased contralateral hippocampal atrophy in depressed (BDI≥14) mTLE patients [62]. Others have not found an association between depression and hippocampal atrophy using hippocampal volumetry studies [55,56,59].…”

Section: Structural Changesmentioning

confidence: 91%

“…Structural imaging studies report increased depressive morbidity, in pathologically heterogeneous TLE patients, with enlarged amygdalar volume [54,55], or preserved T 2 relaxometry in the contralateral amgydala of TLE-positive hippocampal sclerosis patients [56]. Mesial TLE (mTLE) has also been implicated [57,58], but this is not a consistent finding [53,59,60].…”

Section: Structural Changesmentioning

confidence: 99%

“…Mesio-temporal structures are not the only limbic regions involved in depression, both in primary mood disorders and in PWE [55,56,64], as extratemporal abnormalities have been identified in both clinical populations [65,66], suggesting dysfunction of a distributed neural network. Indeed, there is a large body of evidence of structural and functional abnormalities in primary depression, implicating orbital and medial prefrontal cortices, and anatomically related structures within the limbic, striatal, thalamic, and basal forebrain structures [65][66][67].…”

Section: Structural Changesmentioning

confidence: 99%

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Biomarkers of Epileptogenesis: Psychiatric Comorbidities (?)

Kanner

Mazarati

Koepp³

2014

Neurotherapeutics

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The last decade has witnessed a significant shift on our understanding of the relationship between psychiatric disorders and epilepsy. While traditionally psychiatric disorders were considered as a complication of the underlying seizure disorder, new epidemiologic data, supported by clinical and experimental research, have suggested the existence of a bidirectional relation between the two types of conditions: not only are patients with epilepsy at greater risk of experiencing a psychiatric disorder, but patients with primary psychiatric disorders are at greater risk of developing epilepsy. Do these data suggest that some of the pathogenic mechanisms operant in psychiatric comorbidities play a role in epileptogenesis? The aim of this article is to review the epidemiologic data that demonstrate that primary psychiatric disorders are more frequent in people who develop epilepsy, before the onset of the seizure disorder than among controls. The next question looks at the available data of pathogenic mechanisms of primary mood disorders and their potential for facilitating the development and/or exacerbation in the severity of epileptic seizures. Finally, we review data derived from experimental studies in animal models of depression and epilepsy that support a potential role of pathogenic mechanisms of mood disorders in the development of epileptic seizures and epileptogenesis. The data presented in this article do not yet establish conclusive evidence of a pathogenic role of psychiatric comorbidities in epileptogenesis, but raise important research questions that need to be investigated in experimental, clinical, and population-based epidemiologic research studies.

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Mood State, Anxiety, and Psychosis in Epilepsy

Salzberg

2015

Epilepsy and the Interictal State

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Structural and functional neuroimaging correlates of depression in temporal lobe epilepsy

Cited by 64 publications

References 48 publications

The use of neuroimaging to study behavior in patients with epilepsy

The use of neuroimaging to study behavior in patients with epilepsy

Biomarkers of Epileptogenesis: Psychiatric Comorbidities (?)

Mood State, Anxiety, and Psychosis in Epilepsy

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