Structural and functional neural adaptations in obstructive sleep apnea: An activation likelihood estimation meta-analysis

Tahmasian, Masoud; Rosenzweig, Ivana; Eickhoff, Simon B.; Sepehry, Amir Ali; Laird, Angela R.; Fox, Peter T.; Morrell, Mary J.; Khazaie, Habibolah; Eickhoff, Claudia R.

doi:10.1016/j.neubiorev.2016.03.026

Cited by 106 publications

(117 citation statements)

References 138 publications

(235 reference statements)

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“…In a similar vein, an aberrant connectivity between the hippocampus and the cerebellum, which has been previously reported in OSA patients, may lead to alterations in a distributed memory system for associative learning (59). On the other hand, an atypical engagement of the insula within the salience network appears to be common feature of OSA as well as of several neuropsychiatric disorders, including AD and MDD (10).…”

Section: Neuroanatomy Of Osasupporting

confidence: 53%

“…In a recent comprehensive meta-analysis of functional and structural neuroimaging studies (10), structural atrophy and functional disturbances in the right basolateral amygdala, the hippocampus and the right central insula were demonstrated (Figures 1,2). Behavioural analyses of these regions suggested associated dysfunction of emotional, sensory and cognitive processes (Figure 3), and further highlighted a diffuse network within the bilateral anterior insula, posterior-medial frontal cortex and thalamus ( Figure 4).…”

Section: Neuroanatomy Of Osamentioning

confidence: 98%

“…Some of these impairments have been associated with corresponding structural changes (9,10). Continuous positive airway pressure (CPAP)-still the mainstay of OSA treatmenthas been shown to at least partially reverse some of the cognitive impairments and associated neuroanatomical changes (8,(11)(12)(13).…”

Section: Osa and Impaired Cognitionmentioning

confidence: 99%

“…In children with OSA, greater neural recruitment of regions involved in cognitive control, conflict monitoring, and attentional allocation is required in order to perform at the same level as children without OSA (69). Of further note is that the amygdala has a recognised role in the etiology of anxiety disorders, MDD, and PTSD, potentially contributing to the increased prevalence of these psychopathologies in patients with OSA (10). The activation of the amygdala during emotional arousal enhances memory, in part by modulating plasticity in the hippocampus.…”

Section: Neuroanatomy Of Osamentioning

confidence: 99%

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Emerging co-morbidities of obstructive sleep apnea: cognition, kidney disease, and cancer

Gildeh¹,

Drakatos²,

Higgins³

et al. 2016

J. Thorac. Dis.

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Obstructive sleep apnea (OSA) causes daytime fatigue and sleepiness, and has an established relationship with cardiovascular and metabolic disease. Recent years have seen the emergence of an evidence base linking OSA with an increased risk of degenerative neurological disease and associated cognitive impairment, an accelerated rate of decline in kidney function with an increased risk of clinically significant chronic kidney disease (CKD), and with a significantly higher rate of cancer incidence and death. This review evaluates the evidence base linking OSA with these seemingly unrelated co-morbidities, and explores potential mechanistic links underpinning their development in patients with OSA, including intermittent hypoxia (IH), sleep fragmentation, sympathetic excitation, and immune dysregulation.

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Section: Neuroanatomy Of Osasupporting

confidence: 53%

Section: Neuroanatomy Of Osamentioning

confidence: 98%

Section: Osa and Impaired Cognitionmentioning

confidence: 99%

Section: Neuroanatomy Of Osamentioning

confidence: 99%

See 2 more Smart Citations

Emerging co-morbidities of obstructive sleep apnea: cognition, kidney disease, and cancer

Gildeh¹,

Drakatos²,

Higgins³

et al. 2016

J. Thorac. Dis.

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View full text Add to dashboard Cite

show abstract

“…Rapid eye movement sleep plays an important role in modulating noradrenergic brain stem activity, and the activity of amygdala and medial prefrontal cortex, two regions crucial for detecting emotional salience. This is related to the findings of a meta-analysis on structural and functional abnormalities in OSA, which highlighted the role of the right amygdala, hippocampus, and insula in abnormal emotional and sensory processing in OSA (45). It has been discussed that OSA decreases the percentage of REM sleep, which results in dysfunction of brain circuitry related to emotion and mood regulation.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 90%

Higher Risk for Obstructive Sleep Apnea in Chronic Treatment-Resistant Depression

Khazaie

Alavi-Mehr

Younesi

et al. 2018

Iran J Psychiatry Behav Sci

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Objectives: Studies have reported a higher risk for obstructive sleep apnea (OSA) in major depressive disorder (MDD). However, the risk of OSA in patients with chronic treatment-resistant depressive symptoms is not well documented worldwide. Hence, the current study assessed the risk of OSA and associated factors in patients with chronic treatment resistant depression (cTRD). Methods: The study recruited 140 Iranian patients with cTRD. All patients completed the Berlin questionnaire, which evaluates the risk of OSA. Additionally, demographic data and history of cardiovascular or metabolic diseases were collected. Pearson's Chi-square test, Fisher's exact test, and independent T-test were used to assess group differences, when appropriate. Results: The study found that 89 of 140 cTRD patients (64%) were at high risk for OSA. Group comparison between cTRD patients (high vs. low risk for OSA) demonstrated that at high risk OSA-cTRD patients had an elevated rate of hypertension, diabetes mellitus, and obesity. Also, age, duration of depression, and duration of treatment were significantly higher in cTRD patients with higher risk compared to those with lower risk for OSA. Conclusions:The results suggest that a noticeable number of patients with cTRD are at high risk for OSA, which is higher than the reported magnitude in the general population. Moreover, hypertension, diabetes mellitus, and obesity are associated with a higher risk for OSA. Also, age, treatment duration, and depression duration could be considered as possible comorbid factors for OSA in patients with cTRD.

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Association of Sleep-Disordered Breathing With Alzheimer Disease Biomarkers in Community-Dwelling Older Adults

André¹,

Rehel²,

Kuhn

et al. 2020

JAMA Neurol

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 Question: Which brain changes are associated with sleep-disordered breathing (SDB) in aging?  Findings: In this cross-sectional study of 127 cognitively unimpaired communitydwelling older individuals, the presence of SDB was associated with greater amyloid burden, gray matter volume, metabolism, and perfusion in the posterior cingulate cortex and precuneus. There was no association with cognitive performance, selfreported cognitive or sleep difficulties, nor excessive daytime sleepiness.  Meaning: SDB-related changes include amyloid deposition in brain regions typically involved in Alzheimer's disease (AD), which might explain why SDB is associated with an increased risk for developing Alzheimer's clinical syndrome at a younger age.

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Structural and functional neural adaptations in obstructive sleep apnea: An activation likelihood estimation meta-analysis

Cited by 106 publications

References 138 publications

Emerging co-morbidities of obstructive sleep apnea: cognition, kidney disease, and cancer

Emerging co-morbidities of obstructive sleep apnea: cognition, kidney disease, and cancer

Higher Risk for Obstructive Sleep Apnea in Chronic Treatment-Resistant Depression

Association of Sleep-Disordered Breathing With Alzheimer Disease Biomarkers in Community-Dwelling Older Adults

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