Structural and functional MRI correlates of inflammation in bipolar disorder: A systematic review

Saccaro, Luigi Francesco; Crokaert, Jasper; Perroud, Nader; Piguet, Camille

doi:10.1016/j.jad.2022.12.162

Cited by 20 publications

(17 citation statements)

References 71 publications

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“…Interestingly, one recent study also proved that mindfulness could positively impact the FC of BD patients (407). Mindfulness has additionally been suggested to modulate saliency and SMN processing (408), which are part of ER processing (269) and may be disrupted in EDD (254). While there are no studies assessing the relation between mindfulness, ED, and inflammation in EDD to our knowledge, previous work on healthy adults reported that mindfulness was associated with lower peripheral IL-6, and this association was partially explained by modifications in brain FC involving dlPFC (409).…”

Section: Conclusion On Inflammation and Edd: Similarities Differences...mentioning

confidence: 99%

“…Some interesting lines of evidence come from studies assessing MRI correlates of peripheral inflammatory markers simultaneously in BD patients. Although preliminary, the literature suggests a qualitative trend towards central proinflammatory marker concentrations and impairments in ERassociated networks, as summarised by a recent systematic review (254); however, this association has not been detected by other studies (255). As concerns structural MRI abnormalities, several works reported decreased volumes in limbic brain areas tied to increased peripheral proinflammatory markers.…”

Section: Inflammatory Correlates Of Behavioural and Neurobiological M...mentioning

confidence: 99%

“…Indeed, proinflammatory interleukins (IL-6, 8) have been associated with hypoactive SMN in depressed BD patients (on both pre-and postcentral gyri) (222,257). One tempting speculation based on these results is that depressive states, characterized by apathy and reduced psychomotor activity, could be associated with reduced activation of somatomotor areas (254), although the precise link between inflammation and ER is still unclear.…”

Section: Inflammatory Correlates Of Behavioural and Neurobiological M...mentioning

confidence: 99%

“…Further characterization of the circuits linking ER strategies to inflammation may help identify context-appropriate strategies. (254)). Emotion dysregulation (ED) symptoms may lead to higher chronic stress and trauma, which are in turn associated with a proinflammatory state.…”

Section: Conclusion On Inflammation and Edd: Similarities Differences...mentioning

confidence: 99%

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Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Petruso¹,

Giff²,

Milano³

et al. 2023

Preprint

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Emotion dysregulation (ED) describes a difficulty with the modulation of which emotions are felt, as well as when and how these emotions are experienced or expressed. It is a focal overarching symptom in many severe and prevalent neuropsychiatric diseases, including bipolar disorders (BD), attention deficit and hyperactivity disorder (ADHD), and borderline personality disorder (BPD). In all these disorders, ED can manifest through symptoms of depression, anxiety, or affective lability. Considering the many similarities in symptoms between BD, ADHD, and BPD, a transdiagnostic approach is a promising lens of investigation. Mounting evidence supports the role of peripheral inflammatory markers and stress in the multifactorial aetiology and physiopathology of BD, ADHD, and BPD. Of note, neural circuits that regulate emotions appear particularly vulnerable to inflammatory insults and peripheral inflammation, which can impact the neuroimmune milieu of the central nervous system. Thus far, few studies have examined the link between ED and inflammation in BD, ADHD, and BPD. To our knowledge, no specific work has provided a critical comparison of the results from these disorders. To fill this gap in the literature, we review the known associations and mechanisms linking ED and inflammation in general, and clinically, in BD, ADHD, and BD. Our narrative review begins with an examination of the routes linking ED and inflammation, followed by a discussion of disorder-specific results accounting for methodological limitations and relevant confounding factors. Finally, we critically discuss both correspondences and discrepancies in the results and comment on potential vulnerability markers and promising therapeutic interventions.

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Section: Conclusion On Inflammation and Edd: Similarities Differences...mentioning

confidence: 99%

Section: Inflammatory Correlates Of Behavioural and Neurobiological M...mentioning

confidence: 99%

Section: Inflammatory Correlates Of Behavioural and Neurobiological M...mentioning

confidence: 99%

Section: Conclusion On Inflammation and Edd: Similarities Differences...mentioning

confidence: 99%

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Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Petruso¹,

Giff²,

Milano³

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…The latter includes for instance motor agitation and hyperesthesia during mania, or the somatomotor slowing and dulling associated with depressive symptoms (Bowden, 2005). Interestingly, increasing evidence points to the involvement of somatomotor networks (SMN) in emotional and cognitive processing, with SMN having recently become a pivotal area of brain networks research in BD (Ellard et al., 2018; Kebets et al., 2019; Magioncalda et al., 2020; Ping et al., 2022; Saccaro et al., 2023; Tang et al, 2021; Wang et al., 2020; Zhu et al., 2022). Disrupted internetwork stationary functional connectivity (FC) has been shown in BD in the somatomotor network (SMN), default mode network (DMN), salience system (SN), and frontoparietal network (FPN).…”

Section: Introductionmentioning

confidence: 99%

Dynamic functional hippocampal markers of residual depressive symptoms in euthymic bipolar disorder

et al. 2023

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Objectives : Bipolar disorder (BD) is a severe, chronic, affective disorder characterized by recurrent switching between mood states, psychomotor and cognitive symptoms, which can linger in euthymic states as residual symptoms. Hippocampal alterations may play a key role in the neural processing of BD symptoms. However, its dynamic functional connectivity (dFC) remains unclear. Therefore, the present study explores hippocampal dFC in relation to BD symptoms. Methods : We assessed hippocampus‐based dFC coactivation patterns (CAPs) on resting‐state fMRI data of 25 euthymic BD patients and 25 age‐ and sex‐matched healthy controls (HC). Results : Bilateral hippocampal dFC with somatomotor networks (SMN) was reduced in BD, compared to HC, while at the same time dFC between the left hippocampus and midcingulo‐insular salience system (SN) was higher in BD. Correlational analysis between CAPs and clinical scores revealed that dFC between the bilateral hippocampus and the default‐like network (DMN) correlated with depression scores in BD. Furthermore, pathological hyperconnectivity between the default mode network (DMN) and SMN and the frontoparietal network (FPN) was modulated by the same depression scores in BD. Conclusions : Overall, we observed alterations of large‐scale functional brain networks associated with decreased flexibility in cognitive control, salience detection, and emotion processing in BD. Additionally, the present study provides new insights on the neural architecture underlying a self‐centered perspective on the environment in BD patients. dFC markers may improve detection, treatment, and follow‐up of BD patients and of disabling residual depressive symptoms in particular.

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Socioeconomic Disadvantage Moderates the Association of Systemic Inflammation With Amygdala Volume in Adolescents Over a 2-Year Interval: An Exploratory Study

Yuan,

Jaeger,

Coury

et al. 2024

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Structural and functional MRI correlates of inflammation in bipolar disorder: A systematic review

Cited by 20 publications

References 71 publications

Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Dynamic functional hippocampal markers of residual depressive symptoms in euthymic bipolar disorder

Socioeconomic Disadvantage Moderates the Association of Systemic Inflammation With Amygdala Volume in Adolescents Over a 2-Year Interval: An Exploratory Study

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