Structural and Functional Magnetic Resonance Imaging of Dementia With Lewy Bodies

Balážová, Zuzana; Novàkovâ, Marie; Minsterová, Alžběta Šejnoha; Rektorová, Irena

doi:10.1016/bs.irn.2018.10.005

Cited by 9 publications

(6 citation statements)

References 190 publications

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“…Other studies have evaluated the changes of FA in PD and DLB with and without hallucinations [117,118], and comparing DLB to AD [119]. However, the majority did not compare PDD with DLB [120], with one study showing that FA in patients with DLB was significantly decreased in bilateral posterior temporal, posterior cingular, and bilateral visual association fibers extending into occipital areas (p < 0.001) [121].…”

Section: Biomarkers For Lewy Body Dementiasmentioning

confidence: 99%

“…As in the case of other techniques, the majority of studies evaluate changes of fMRI comparing PDD and DLB against controls or AD [120], but comparisons between PDD and DLB are scarce.…”

Section: Functional Magnetic Resonance Imagingmentioning

confidence: 99%

“…[93,102]. DTI: controversial, corticostriatal disruption in PDD is more frontal and in DLB more posterior (parietal and occipital) [39,102,120]. SWI: Nigrosome 1 "swallow tail sign" differentiates PD from controls [124].…”

Section: Neurophysiological Biomarkersmentioning

confidence: 99%

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Lewy Body Dementias: A Coin with Two Sides?

Milán-Tomás

Fernández‐Matarrubia

Rodríguez‐Oroz

2021

Behavioral Sciences

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Lewy body dementias (LBDs) consist of dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), which are clinically similar syndromes that share neuropathological findings with widespread cortical Lewy body deposition, often with a variable degree of concomitant Alzheimer pathology. The objective of this article is to provide an overview of the neuropathological and clinical features, current diagnostic criteria, biomarkers, and management of LBD. Literature research was performed using the PubMed database, and the most pertinent articles were read and are discussed in this paper. The diagnostic criteria for DLB have recently been updated, with the addition of indicative and supportive biomarker information. The time interval of dementia onset relative to parkinsonism remains the major distinction between DLB and PDD, underpinning controversy about whether they are the same illness in a different spectrum of the disease or two separate neurodegenerative disorders. The treatment for LBD is only symptomatic, but the expected progression and prognosis differ between the two entities. Diagnosis in prodromal stages should be of the utmost importance, because implementing early treatment might change the course of the illness if disease-modifying therapies are developed in the future. Thus, the identification of novel biomarkers constitutes an area of active research, with a special focus on α-synuclein markers.

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Section: Biomarkers For Lewy Body Dementiasmentioning

confidence: 99%

“…As in the case of other techniques, the majority of studies evaluate changes of fMRI comparing PDD and DLB against controls or AD [120], but comparisons between PDD and DLB are scarce.…”

Section: Functional Magnetic Resonance Imagingmentioning

confidence: 99%

See 1 more Smart Citation

Lewy Body Dementias: A Coin with Two Sides?

Milán-Tomás

Fernández‐Matarrubia

Rodríguez‐Oroz

2021

Behavioral Sciences

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“…Dementia with Lewy bodies (DLB) is the second most common cognitive progressive disorder after Alzheimer's disease (AD), accounting for 15%–20% of pathologically diagnosed dementia cases (McKeith et al, 2017). Although the underlying brain mechanisms remain poorly understood, previous imaging studies highlighted that DLB, especially at the early stages, is characterized more by functional disturbances than by significant macroscopic structural changes (Balážová et al, 2019). Compared to AD patients, DLB patients show a less pronounced global atrophy, with a more diffuse and less focal pattern (Balážová et al, 2019; Watson et al, 2012) and a relative preservation of medial temporal lobes (Watson et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Microstructural changes in prodromal dementia with Lewy bodies compared to normal ageing: Multiparametric quantitative MRI evidences

Chabran

Mondino

Noblet

et al. 2022

Eur J of Neuroscience

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Dementia with Lewy bodies (DLB) patients show few significant macroscopic structural changes, especially at the early stages of the disease, making quantitative MRI especially interesting to explore more subtle changes that are not detectable by conventional volumetric techniques. Microstructural alterations have been reported in DLB at the dementia stage, but no study to date was conducted in prodromal patients. Here, quantitative MRI data were collected from 46 DLB prodromal patients and 20 healthy elderly subjects, who also underwent a detailed clinical examination including the Mayo Clinic Fluctuation Scale. We conducted voxel‐wise between‐group comparisons in diffusion tensor imaging (DTI) metrics and in R2* mapping, along with a multivariate analysis combining the two modalities. We highlighted multiple grey matter and white matter microstructural changes in DLB patients at the prodromal stage, compared to control subjects. Our multivariate analysis identified three distinct regional patterns of DTI and R2* changes (anterior, anteromedial, posterior) in DLB patients, that could reflect different neuropathological processes across brain regions. We also observed an association between R2* alterations in the thalamus, and the severity of fluctuations, in the DLB group. These preliminary findings are promising and require future investigations to better understand the biological underpinnings of microstructural alterations.

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“…MostOstudiesOperformedOmeasurementsOonO3TOscanners [21]; however,ppthereOareOnoOmajor differencesOin Voxel Based Morphometry/SurfaceOBasedOAnalysis resultsOwhenOmeasurements areOperformedOonO1.5T cameras. OMostOcommonOapproaches to the wholeObrainOdataOevaluationOwhenOcomparingOgroupsOofOsubjects areObriefly introducedOin the text below.…”

Section: Structural Magnetic Resonance Imaging (Smri)mentioning

confidence: 99%

Application of graph convolutional neural networks to Alzheimer's and Parkinson's disease classification

Goli¹

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Structural and Functional Magnetic Resonance Imaging of Dementia With Lewy Bodies

Cited by 9 publications

References 190 publications

Lewy Body Dementias: A Coin with Two Sides?

Lewy Body Dementias: A Coin with Two Sides?

Microstructural changes in prodromal dementia with Lewy bodies compared to normal ageing: Multiparametric quantitative MRI evidences

Application of graph convolutional neural networks to Alzheimer's and Parkinson's disease classification

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