Structural and functional insights in polysaccharides coated cerium oxide nanoparticles and their potential biomedical applications: A review

Yadav, Somu; Chamoli, Shivangi; Kumar, Piyush; Maurya, Pawan Kumar

doi:10.1016/j.ijbiomac.2023.125673

Cited by 21 publications

(8 citation statements)

References 138 publications

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“…МикроРНК действует на противовоспалитель ный путь NFkB, таким образом, захватывается три основных механизма ранозаживления (противовос палительный, проангиогенный, антиоксидантный), что позволяет качественно и эффективно ускорять регенерацию. Однако авторы отмечают, что эти на ночастицы могут переходить в агломераты, пони жающие их биологическую эффективность [28,29].…”

Section: покрытие наночастицыunclassified

Nanomaterials based on cerium oxide nanoparticles for wound regeneration: a literature review

Silina,

Manturova,

Erokhina

et al. 2023

RJTAO

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Objective: to analyze data on the synthesis and properties of cerium oxide nanoparticles, as well as the prospects of its application in regenerative medicine for wound healing. Methodology. World literature was reviewed using PubMed, SCOPUS, ResearchGate, CyberLeninck, and Elibrary databases, as well as manual searches for authors and reference lists. Key search terms were «cerium oxide» AND nano* AND (healing OR regeneration OR repair) AND wound». The timeline was from the date of publication through August 2023. Results. The final analysis included 59 sources containing information on the synthesis and size of nanoparticles (and/or other physicochemical characteristics), methodology and results of in vivo and in vitro studies on the efficacy and/or safety of nanoceria for wound regeneration. It is shown that despite the progressive growth of research interest over the last 15 years, the actual use of nanoceria in practical medicine is still not widespread. This is due to a wide variety of non-standardized synthesis methods and conditions, resulting in the variability of physicochemical parameters of nanoparticles (size, form), thereby affecting the safety and biomedical efficacy of nanoceria. Regeneration mechanisms, including the antioxidant-prooxidant, anti-inflammatory and antimicrobial effects of nanoceria, which contribute to accelerated wound healing, are discussed. The severity of the regenerative effects depends on the method and conditions of synthesis, hence the resulting physicochemical characteristics of the nanoparticles. Therefore, after each batch, newly synthesized nanoceria needs physicochemical and biomedical experimental tests. Conclusion. Nanoceria has great potential in tissue engineering for regenerative medicine, particularly for healing of various kinds of wounds. Having developed a technology for standardized synthesis for effective and safe nanoceria (of the right form and size) on a production scale, it can be introduced in medicine, possibly improving the outcomes of treatment of many diseases and pathologies. The authors present conclusions on the results of the study of nanoceria for accelerating qualitative regeneration and the requirements for nanoparticles obtained during synthesis.

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Section: покрытие наночастицыunclassified

Nanomaterials based on cerium oxide nanoparticles for wound regeneration: a literature review

Silina,

Manturova,

Erokhina

et al. 2023

RJTAO

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“…15–18 The application of cerium oxide nanoparticles is related to their activity and stability, which depends on their size, shape, composition (such as Ce 3+ /Ce 4+ ratios), and other structural factors. 19,20 Obtaining atomically precise structures of cerium oxide nanoclusters can help understand how structural factors affect their properties; however, identifying the structures of pristine CeO 2 clusters is still challenging in experimental work.…”

Section: Introductionmentioning

confidence: 99%

Exploring the stable structures of cerium oxide nanoclusters using high-dimensional neural network potential

Cai,

Ren,

Gao

2024

Nanoscale Adv.

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“…Cerium oxide nanoparticles (CeO NPs) emerged as one of the first RE NMs in medical applications, as Ce is the most abundant REE. Moreover, due to their remarkable antioxidant, anti-inflammatory, antibacterial, angiogenic, and antiapoptotic activities, CeO NPs have attracted significant attention for use in bone regeneration [ 21 ]. With further investigation, additional RE NMs, such as lanthanum oxide NPs [ 13 ], Gd@C 82 (OH) 22 NPs [ 22 ] and β-NaGdF 4 :Yb/Er upconversion NPs [ 12 ], have been found to promote osteogenesis.…”

Section: Introductionmentioning

confidence: 99%

Systematic review of the osteogenic effect of rare earth nanomaterials and the underlying mechanisms

Chen,

Zhou,

et al. 2024

J Nanobiotechnol

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Rare earth nanomaterials (RE NMs), which are based on rare earth elements, have emerged as remarkable biomaterials for use in bone regeneration. The effects of RE NMs on osteogenesis, such as promoting the osteogenic differentiation of mesenchymal stem cells, have been investigated. However, the contributions of the properties of RE NMs to bone regeneration and their interactions with various cell types during osteogenesis have not been reviewed. Here, we review the crucial roles of the physicochemical and biological properties of RE NMs and focus on their osteogenic mechanisms. RE NMs directly promote the proliferation, adhesion, migration, and osteogenic differentiation of mesenchymal stem cells. They also increase collagen secretion and mineralization to accelerate osteogenesis. Furthermore, RE NMs inhibit osteoclast formation and regulate the immune environment by modulating macrophages and promote angiogenesis by inducing hypoxia in endothelial cells. These effects create a microenvironment that is conducive to bone formation. This review will help researchers overcome current limitations to take full advantage of the osteogenic benefits of RE NMs and will suggest a potential approach for further osteogenesis research. Graphical abstract

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Structural and functional insights in polysaccharides coated cerium oxide nanoparticles and their potential biomedical applications: A review

Cited by 21 publications

References 138 publications

Nanomaterials based on cerium oxide nanoparticles for wound regeneration: a literature review

Nanomaterials based on cerium oxide nanoparticles for wound regeneration: a literature review

Exploring the stable structures of cerium oxide nanoclusters using high-dimensional neural network potential

Systematic review of the osteogenic effect of rare earth nanomaterials and the underlying mechanisms

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