PLoS ONE volume 9, issue 5, Pe98346 2014 DOI: 10.1371/journal.pone.0098346 View full text
Yingwei Qiu, Xiaofei Lv, Huanhuan Su, Guihua Jiang, Cheng Li, Junzhang Tian

Abstract: Background and PurposeCognitive impairment is a well-described phenomenon in end-stage renal disease (ESRD) patients. However, its pathogenesis remains poorly understood. The primary focus of this study was to examine structural and functional brain deficits in ESRD patients.Materials and MethodsThirty ESRD patients on hemodialysis (without clinical neurological disease) and 30 age- and gender-matched control individuals (without renal or neurological problems) were recruited in a prospective, single-center st…

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